HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS

Detalhes bibliográficos
Autor(a) principal: Falangola, Maria de Fátima
Data de Publicação: 1995
Outros Autores: Hanly, A, Castro Filho, Bernardo Galvão, Petito, C. K
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15498
Resumo: National Institutes of Health NINDS e Conselho Nacional de Desenvolvimento Científico e Tecnológico
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spelling Falangola, Maria de FátimaHanly, ACastro Filho, Bernardo GalvãoPetito, C. K2016-08-29T16:21:24Z2016-08-29T16:21:24Z1995FALANGOLA, M. F. et al. HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS. Journal of Neuropathology and Experimental Neurology, v. 54, n. 4, p. 497-503, 1995.0022-3069https://www.arca.fiocruz.br/handle/icict/15498National Institutes of Health NINDS e Conselho Nacional de Desenvolvimento Científico e TecnológicoFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Miami School of Medicine. Department of Pathology. FL, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Miami School of Medicine. Department of Pathology. FL, USAThe present study examines the hypothesis that HIV infection of the choroid plexus (CPx) may be an important site of viral entry into the brain. Formalin-fixed, paraffin-embedded CPx was obtained from 25 patients with AIDS and 13 nonAIDS patients and was processed for light microscopy and for immunohistochemical detection of HIV gp41, T and B lymphocytes, monocytes/macrophages and endothelial cells. Eleven of the 13 nonAIDS CPx were normal and 2 contained inflammatory foci of undetermined etiology. The stroma contained T lymphocytes in all and monocytes in 22%; B lymphocytes and HIV antigen were absent. Choroid plexus of the AIDS cases contained opportunistic infections or lymphoma in 12 and inflammatory foci alone in 6; 7 were normal. T lymphocytes were present in 70% and monocytes in 50%. In addition to the stromal localization, monocytes also were present in supra-epithelial regions and within or adjacent to the capillary endothelium. HIV-positive cells in the CPx were found in 11 cases (44%) and in the supra-epithelial area in another 2. Their presence correlated with neither infection nor lymphoma of the CPx or brain. They were situated in the stroma, supra-epithelial region and (rarely) capillary endothelium. Immunohistochemistry on serial sections identified the HIV-infected cells as monocytes, including those by capillary endothelium and in supra-epithelial areas. The study demonstrates that the CPx contains HIV-infected monocytes in almost half of the cases. Their apposition to endothelium suggests hematogenous origin. These results support the hypothesis that HIV encephalitis may develop from CPx infectionengOxford University PressHIV infection of human choroid plexus: a possible mechanism of viral entry into the CNSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAIDSBrainChroides plexusEncephalitisHIVinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15498/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFalangola MF HIV infection of human....pdfFalangola MF HIV infection of human....pdfapplication/pdf532706https://www.arca.fiocruz.br/bitstream/icict/15498/2/Falangola%20MF%20HIV%20infection%20of%20human....pdf4dc92111e3a15f88d237790b55d67cadMD52TEXTFalangola MF HIV infection of human....pdf.txtFalangola MF HIV infection of human....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS
title HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS
spellingShingle HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS
Falangola, Maria de Fátima
AIDS
Brain
Chroides plexus
Encephalitis
HIV
title_short HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS
title_full HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS
title_fullStr HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS
title_full_unstemmed HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS
title_sort HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS
author Falangola, Maria de Fátima
author_facet Falangola, Maria de Fátima
Hanly, A
Castro Filho, Bernardo Galvão
Petito, C. K
author_role author
author2 Hanly, A
Castro Filho, Bernardo Galvão
Petito, C. K
author2_role author
author
author
dc.contributor.author.fl_str_mv Falangola, Maria de Fátima
Hanly, A
Castro Filho, Bernardo Galvão
Petito, C. K
dc.subject.en.pt_BR.fl_str_mv AIDS
Brain
Chroides plexus
Encephalitis
HIV
topic AIDS
Brain
Chroides plexus
Encephalitis
HIV
description National Institutes of Health NINDS e Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 1995
dc.date.issued.fl_str_mv 1995
dc.date.accessioned.fl_str_mv 2016-08-29T16:21:24Z
dc.date.available.fl_str_mv 2016-08-29T16:21:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv FALANGOLA, M. F. et al. HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS. Journal of Neuropathology and Experimental Neurology, v. 54, n. 4, p. 497-503, 1995.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15498
dc.identifier.issn.pt_BR.fl_str_mv 0022-3069
identifier_str_mv FALANGOLA, M. F. et al. HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS. Journal of Neuropathology and Experimental Neurology, v. 54, n. 4, p. 497-503, 1995.
0022-3069
url https://www.arca.fiocruz.br/handle/icict/15498
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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