The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1177/1470320314540733 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8158 |
Resumo: | State University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, Brasil |
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Freire, Ivna VidalMachado, MarcoRibeiro, Ícaro José SantosHackney, Anthony CBarbosa, Ana Angélica LealPereira, Rafael2014-08-08T19:24:28Z2014-08-08T19:24:28Z2014FREIRE, I. V. et al. The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises. Journal of the Renin-Angiotensin-Aldosterone System, 2014.1470-3203,https://www.arca.fiocruz.br/handle/icict/815810.1177/1470320314540733engSage PublicationsThe D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercisesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleState University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, BrasilUniversitary Fundation of Itaperuna. Laboratory of Human Movement Studies. Itaperuna, RJ, Brasil / Universidade Iguaçu Itaperuna. Laboratory of Physiology and Biokinetics. Itaperuna, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversity of North Carolina. Endocrine Section. Applied Physiology Laboratory. Chapel Hill, USAState University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, BrasilState University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, BrasilHypothesis/introduction: The association of ACE I/D polymorphism and hemodynamic response to exercise have been limited to primarily aerobic exercises. We hypothesized that D allele carriers would show greater hemodynamic response to resistance exercise, as has been observed with aerobic. This study aimed to investigate the association of ACE I/D polymorphism and hemodynamic (blood pressure (BP), heart rate (HR) and rate-pressure product (RPP)) response to resistance exercise in young healthy subjects. Materials and methods: ACE I/D polymorphisms were studied by PCR analysis from 75 healthy men. Subjects completed a resistance exercise session of three sets of 10 knee extension repetitions with loads of 50, 75 and 100% of 10RM and two-minute rest intervals. Hemodynamic measures were recorded before and immediately after each set. Analysis of variance was used to identify significant differences among ACE genotypes. Results: ACE I/D polymorphism is associated with hemodynamic response to resistance exercise, as healthy subjects with ACE D allele were prone to higher responses. In addition, this phenotypic difference seems to be a load-dependent trend. Conclusion: ACE DD carriers exhibit greater heart work during resistance exercise. Future studies should focus on the influence of resistance training period with different workloads on the hemodynamic response in healthy individuals with different ACE genotypes.Renin-angiotensin systemCandidate geneACE I/D polymorphismExerciseBlood pressureinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFreire IV The D allele....pdfFreire IV The D allele....pdfapplication/pdf856583https://www.arca.fiocruz.br/bitstream/icict/8158/1/Freire%20IV%20The%20D%20allele....pdf0381d9dd6603a77ff21a805c56877e44MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8158/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTFreire IV The D allele....pdf.txtFreire IV The D allele....pdf.txtExtracted texttext/plain38228https://www.arca.fiocruz.br/bitstream/icict/8158/3/Freire%20IV%20The%20D%20allele....pdf.txte6379a6b7f815100548efedcfdff5fa6MD53icict/81582023-03-15 14:33:56.409oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises |
| title |
The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises |
| spellingShingle |
The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises Freire, Ivna Vidal Renin-angiotensin system Candidate gene ACE I/D polymorphism Exercise Blood pressure |
| title_short |
The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises |
| title_full |
The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises |
| title_fullStr |
The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises |
| title_full_unstemmed |
The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises |
| title_sort |
The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises |
| author |
Freire, Ivna Vidal |
| author_facet |
Freire, Ivna Vidal Machado, Marco Ribeiro, Ícaro José Santos Hackney, Anthony C Barbosa, Ana Angélica Leal Pereira, Rafael |
| author_role |
author |
| author2 |
Machado, Marco Ribeiro, Ícaro José Santos Hackney, Anthony C Barbosa, Ana Angélica Leal Pereira, Rafael |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Freire, Ivna Vidal Machado, Marco Ribeiro, Ícaro José Santos Hackney, Anthony C Barbosa, Ana Angélica Leal Pereira, Rafael |
| dc.subject.en.pt_BR.fl_str_mv |
Renin-angiotensin system Candidate gene ACE I/D polymorphism Exercise Blood pressure |
| topic |
Renin-angiotensin system Candidate gene ACE I/D polymorphism Exercise Blood pressure |
| description |
State University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, Brasil |
| publishDate |
2014 |
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2014-08-08T19:24:28Z |
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2014-08-08T19:24:28Z |
| dc.date.issued.fl_str_mv |
2014 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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FREIRE, I. V. et al. The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises. Journal of the Renin-Angiotensin-Aldosterone System, 2014. |
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https://www.arca.fiocruz.br/handle/icict/8158 |
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1470-3203, |
| dc.identifier.doi.none.fl_str_mv |
10.1177/1470320314540733 |
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FREIRE, I. V. et al. The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises. Journal of the Renin-Angiotensin-Aldosterone System, 2014. 1470-3203, 10.1177/1470320314540733 |
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Sage Publications |
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Sage Publications |
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