Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/39660 |
Resumo: | Wellcome Trust (grant number 213589/Z/18/Z). The funders had no role in study design, analysis, decision to publish or preparation of the manuscript. |
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Paixão, Enny S.Rodrigues, Moreno S.Cardim, Luciana L.Oliveira, Juliane F.L. C., CatharinaCosta, Maria da Conceição N.Barreto, Maurício LimaRodrigues, Laura C.Smeeth, LiamAndrade, Roberto F. S.Oliveira, Wanderson K.Teixeira, Maria da Glória Lima Cruz2020-01-31T13:49:02Z2020-01-31T13:49:02Z2019PAIXÃO, Enny S. et al. Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis. PLOS Neglected Tropical Diseases, p. 1-12, Sept. 23 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3966010.1371/journal.pntd.0007721Wellcome Trust (grant number 213589/Z/18/Z). The funders had no role in study design, analysis, decision to publish or preparation of the manuscript.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / London School of Hygiene and Tropical Medicine. Epidemiology and Population Health. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. Epidemiology and Population Health. London, United Kingdom.London School of Hygiene and Tropical Medicine. Epidemiology and Population Health. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Física. Salvador, BA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.London School of Hygiene and Tropical Medicine. Epidemiology and Population Health. London, United Kingdom.This study aimed to assess the impact of the Zika epidemic on the registration of birth defects in Brazil. We used an interrupted time series analysis design to identify changes in the trends in the registration of congenital anomalies. We obtained monthly data from Brazilian Live Birth Information System and used two outcome definitions: 1) rate of congenital malformation of the brain and eye (likely to be affected by Zika and its complications) 2) rate of congenital malformation not related to the brain or eye unlikely to be causally affected by Zika. The period between maternal infection with Zika and diagnosis of congenital abnormality attributable to the infection is around six months. We therefore used September 2015 as the interruption point in the time series, six months following March 2015 when cases of Zika started to increase. For the purposes of this analysis, we considered the period from January 2010 to September 2015 to be "pre-Zika event," and the period from just after September 2015 to December 2017 to be "post-Zika event." We found that immediately after the interruption point, there was a great increase in the notification rate of congenital anomalies of 14.9/10,000 live births in the brain and eye group and of 5.2/10,000 live births in the group not related with brain or eye malformations. This increase in reporting was in all regions of the country (except in the South) and especially in the Northeast. In the period "post-Zika event", unlike the brain and eye group which showed a monthly decrease, the group without brain or eye malformations showed a slow but significant increase (relative to the pre-Zika trend) of 0.2/10,000 live births. These findings suggest an overall improvement in the registration of birth malformations, including malformations that were not attributed to Zika, during and after the Zika epidemic.engPublic Library of ScienceZika vírusZika vírus infecçãoGravidezEpidemiaHumanosBrasilZika virusZika virus infectionPregnancyEpidemicsHumanBrazilImpact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39660/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPaixao E S Impact evaluation.. PLoS Neglect Trop Dis.pdfPaixao E S Impact evaluation.. 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| dc.title.en.fl_str_mv |
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis |
| title |
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis |
| spellingShingle |
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis Paixão, Enny S. Zika vírus Zika vírus infecção Gravidez Epidemia Humanos Brasil Zika virus Zika virus infection Pregnancy Epidemics Human Brazil |
| title_short |
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis |
| title_full |
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis |
| title_fullStr |
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis |
| title_full_unstemmed |
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis |
| title_sort |
Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis |
| author |
Paixão, Enny S. |
| author_facet |
Paixão, Enny S. Rodrigues, Moreno S. Cardim, Luciana L. Oliveira, Juliane F. L. C., Catharina Costa, Maria da Conceição N. Barreto, Maurício Lima Rodrigues, Laura C. Smeeth, Liam Andrade, Roberto F. S. Oliveira, Wanderson K. Teixeira, Maria da Glória Lima Cruz |
| author_role |
author |
| author2 |
Rodrigues, Moreno S. Cardim, Luciana L. Oliveira, Juliane F. L. C., Catharina Costa, Maria da Conceição N. Barreto, Maurício Lima Rodrigues, Laura C. Smeeth, Liam Andrade, Roberto F. S. Oliveira, Wanderson K. Teixeira, Maria da Glória Lima Cruz |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paixão, Enny S. Rodrigues, Moreno S. Cardim, Luciana L. Oliveira, Juliane F. L. C., Catharina Costa, Maria da Conceição N. Barreto, Maurício Lima Rodrigues, Laura C. Smeeth, Liam Andrade, Roberto F. S. Oliveira, Wanderson K. Teixeira, Maria da Glória Lima Cruz |
| dc.subject.other.pt_BR.fl_str_mv |
Zika vírus Zika vírus infecção Gravidez Epidemia Humanos Brasil |
| topic |
Zika vírus Zika vírus infecção Gravidez Epidemia Humanos Brasil Zika virus Zika virus infection Pregnancy Epidemics Human Brazil |
| dc.subject.en.en.fl_str_mv |
Zika virus Zika virus infection Pregnancy Epidemics Human Brazil |
| description |
Wellcome Trust (grant number 213589/Z/18/Z). The funders had no role in study design, analysis, decision to publish or preparation of the manuscript. |
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2019 |
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2019 |
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2020-01-31T13:49:02Z |
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2020-01-31T13:49:02Z |
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info:eu-repo/semantics/publishedVersion |
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PAIXÃO, Enny S. et al. Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis. PLOS Neglected Tropical Diseases, p. 1-12, Sept. 23 2019. |
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https://www.arca.fiocruz.br/handle/icict/39660 |
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1935-2727 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0007721 |
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PAIXÃO, Enny S. et al. Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis. PLOS Neglected Tropical Diseases, p. 1-12, Sept. 23 2019. 1935-2727 10.1371/journal.pntd.0007721 |
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