Pluripotency of Wolbachia against Arboviruses: the case of yellow fever
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36229 |
Resumo: | 2021-01-01 |
| id |
CRUZ_a83f86fc92943424e47fa0c6d49cbc84 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/36229 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Rocha, Marcele NevesDuarte, Myrian MoratoMansur, Simone BrutmanSilva, Bianca Daoud Mafra ePereira, Thiago NunesAdelino, Talita Émile RibeiroGiovaneti, MartaAlcantara, Luis Carlos JuniorSantos, Franciele MartinsCosta, Victor Rodrigues de MeloTeixeira, Mauro MartinsIani, Felipe Campos de MeloCosta, Vivian VasconcelosMoreira, Luciano Andrade2019-10-07T17:11:50Z2019-10-07T17:11:50Z2019ROCHA, Marcele Neves et al. Pluripotency of Wolbachia against Arboviruses: the case of yellow fever. Gates Open Research, v. 3, p. 1-27, 2019.2572-4754https://www.arca.fiocruz.br/handle/icict/3622910.12688/gatesopenres.12903.2engBill and Melinda Gates FoundationAedes aegyptiWolbachiaAedes aegyptiWolbachiaYellow fever virusVector competencePluripotency of Wolbachia against Arboviruses: the case of yellow feverinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-01-01Fundação Oswaldo Cruz. Instituto Rene Rachou. Mosquitos Vetores. Belo Horizonte, MG, Brasil.Fundação Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Mosquitos Vetores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Mosquitos Vetores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Mosquitos Vetores. Belo Horizonte, MG, Brasil.Fundação Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Centro de Pesquisa e Desenvolvimento de Fármacos. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Grupo de Pesquisa em Doenças Arbovirais. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Centro de Pesquisa e Desenvolvimento de Fármacos. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Grupo de Pesquisa em Doenças Arbovirais. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Centro de Pesquisa e Desenvolvimento de Fármacos. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Laboratório de Imunofarmacologia. Belo Horizonte, MG, Brasil.Fundação Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Centro de Pesquisa e Desenvolvimento de Fármacos. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Grupo de Pesquisa em Doenças Arbovirais. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Mosquitos Vetores. Belo Horizonte, MG, Brasil.Background: Yellow fever outbreaks have re-emerged in Brazil during 2016-18, with mortality rates up to 30%. Although urban transmission has not been reported since 1942, the risk of re-urbanization of yellow fever is significant, as Aedes aegypti is present in most tropical and sub-tropical cities in the World and still remains the main vector of urban YFV. Although the YFV vaccine is safe and effective, it does not always reach populations at greatest risk of infection and there is an acknowledged global shortage of vaccine supply. The introgression of Wolbachia bacteria into Ae. aegypti mosquito populations is being trialed in several countries ( www.worldmosquito.org) as a biocontrol method against dengue, Zika and chikungunya. Here, we studied the ability of Wolbachia to reduce the transmission potential of Ae. aegypti mosquitoes for Yellow fever virus (YFV). Methods: Two recently isolated YFV (primate and human) were used to challenge field-derived wild-type and Wolbachia-infected ( wMel +) Ae. aegypti mosquitoes. The YFV infection status was followed for 7, 14 and 21 days post-oral feeding (dpf). The YFV transmission potential of mosquitoes was evaluated via nano-injection of saliva into uninfected mosquitoes or by inoculation in mice. Results: We found that Wolbachia was able to significantly reduce the prevalence of mosquitoes with YFV infected heads and thoraces for both viral isolates. Furthermore, analyses of mosquito saliva, through indirect injection into naïve mosquitoes or via interferon-deficient mouse model, indicated Wolbachia was associated with profound reduction in the YFV transmission potential of mosquitoes (14dpf). Conclusions: Our results suggest that Wolbachia introgression could be used as a complementary strategy for prevention of urban yellow fever transmission, along with the human vaccination program.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/36229/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALPluripotency of Wolbachia.pdfPluripotency of Wolbachia.pdfapplication/pdf2367430https://www.arca.fiocruz.br/bitstream/icict/36229/2/Pluripotency%20of%20Wolbachia.pdf57bb0d1268b983f915123594efb16f58MD52TEXTPluripotency of Wolbachia.pdf.txtPluripotency of Wolbachia.pdf.txtExtracted texttext/plain109650https://www.arca.fiocruz.br/bitstream/icict/36229/3/Pluripotency%20of%20Wolbachia.pdf.txt66c8eb3a1ec18953f6bc71d4ae5234fbMD53icict/362292021-03-24 16:32:42.022oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever |
| title |
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever |
| spellingShingle |
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever Rocha, Marcele Neves Aedes aegypti Wolbachia Aedes aegypti Wolbachia Yellow fever virus Vector competence |
| title_short |
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever |
| title_full |
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever |
| title_fullStr |
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever |
| title_full_unstemmed |
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever |
| title_sort |
Pluripotency of Wolbachia against Arboviruses: the case of yellow fever |
| author |
Rocha, Marcele Neves |
| author_facet |
Rocha, Marcele Neves Duarte, Myrian Morato Mansur, Simone Brutman Silva, Bianca Daoud Mafra e Pereira, Thiago Nunes Adelino, Talita Émile Ribeiro Giovaneti, Marta Alcantara, Luis Carlos Junior Santos, Franciele Martins Costa, Victor Rodrigues de Melo Teixeira, Mauro Martins Iani, Felipe Campos de Melo Costa, Vivian Vasconcelos Moreira, Luciano Andrade |
| author_role |
author |
| author2 |
Duarte, Myrian Morato Mansur, Simone Brutman Silva, Bianca Daoud Mafra e Pereira, Thiago Nunes Adelino, Talita Émile Ribeiro Giovaneti, Marta Alcantara, Luis Carlos Junior Santos, Franciele Martins Costa, Victor Rodrigues de Melo Teixeira, Mauro Martins Iani, Felipe Campos de Melo Costa, Vivian Vasconcelos Moreira, Luciano Andrade |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rocha, Marcele Neves Duarte, Myrian Morato Mansur, Simone Brutman Silva, Bianca Daoud Mafra e Pereira, Thiago Nunes Adelino, Talita Émile Ribeiro Giovaneti, Marta Alcantara, Luis Carlos Junior Santos, Franciele Martins Costa, Victor Rodrigues de Melo Teixeira, Mauro Martins Iani, Felipe Campos de Melo Costa, Vivian Vasconcelos Moreira, Luciano Andrade |
| dc.subject.other.pt_BR.fl_str_mv |
Aedes aegypti Wolbachia |
| topic |
Aedes aegypti Wolbachia Aedes aegypti Wolbachia Yellow fever virus Vector competence |
| dc.subject.en.pt_BR.fl_str_mv |
Aedes aegypti Wolbachia Yellow fever virus Vector competence |
| description |
2021-01-01 |
| publishDate |
2019 |
| dc.date.accessioned.fl_str_mv |
2019-10-07T17:11:50Z |
| dc.date.available.fl_str_mv |
2019-10-07T17:11:50Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
ROCHA, Marcele Neves et al. Pluripotency of Wolbachia against Arboviruses: the case of yellow fever. Gates Open Research, v. 3, p. 1-27, 2019. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36229 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2572-4754 |
| dc.identifier.doi.none.fl_str_mv |
10.12688/gatesopenres.12903.2 |
| identifier_str_mv |
ROCHA, Marcele Neves et al. Pluripotency of Wolbachia against Arboviruses: the case of yellow fever. Gates Open Research, v. 3, p. 1-27, 2019. 2572-4754 10.12688/gatesopenres.12903.2 |
| url |
https://www.arca.fiocruz.br/handle/icict/36229 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Bill and Melinda Gates Foundation |
| publisher.none.fl_str_mv |
Bill and Melinda Gates Foundation |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/36229/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/36229/2/Pluripotency%20of%20Wolbachia.pdf https://www.arca.fiocruz.br/bitstream/icict/36229/3/Pluripotency%20of%20Wolbachia.pdf.txt |
| bitstream.checksum.fl_str_mv |
9193a7c197bc67acd023525e72a03240 57bb0d1268b983f915123594efb16f58 66c8eb3a1ec18953f6bc71d4ae5234fb |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008915942604800 |