Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview

Detalhes bibliográficos
Autor(a) principal: Ferreira, J. Oliveira
Data de Publicação: 2001
Outros Autores: Daniel-Ribeiro, Claudio Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44114
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro Colaborador para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.
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spelling Ferreira, J. OliveiraDaniel-Ribeiro, Claudio Tadeu2020-10-22T14:22:58Z2020-10-22T14:22:58Z2001FERREIRA, J. Oliveira; DANIEL-RIBEIRO, Claudio Tadeu. Protective CD8+ T Cell Responses against the Preerythrocytic Stages of Malaria Parasites: an Overview. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 2, p. 221-227, Feb. 2001.0074-0276https://www.arca.fiocruz.br/handle/icict/4411410.1590/S0074-027620010002000141678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Respostas de linfócitos T citotóxicos (CTL)CTL e peptídeos auxiliaresEpítopos CD8 + e CD4 +Vetores recombinantesPartículas semelhantes a vírus Ty (VLP)Cytotoxic T lymphocyte (CTL) responsesCTL and helper peptidesCD8+ and CD4+ epitopesRecombinant vectorsTy-virus like particles (VLP)Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro Colaborador para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro Colaborador para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocytic stage of malaria in mice and humans following irradiated sporozoite immunization. Immunization experiments in animal models by several investigators have suggested different strategies for vaccination against malaria and many of the targets from liver stage malaria antigens have been shown to be immunogenic and to protect mice from the sporozoite challenge. Several prime/boost protocols with replicating vectors, such as vaccinia/influenza, with non-replicating vectors, such as recombinant particles derived from yeast transposon (Ty-particles) and modified vaccinia virus Ankara, and DNA, significantly enhanced CD8+ T cell immunogenicity and also the protective efficacy against the circumsporosoite protein of Plasmodium berghei and P. yeti. Based on these experimental results the development of a CD8+ T cell inducing vaccine has moved forward from epitope identification to planning stages of safety and immunogenicity trials of candidate vaccines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44114/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJOLiveira_CTDRibeiro_IOC_2001.pdfJOLiveira_CTDRibeiro_IOC_2001.pdfapplication/pdf58085https://www.arca.fiocruz.br/bitstream/icict/44114/2/JOLiveira_CTDRibeiro_IOC_2001.pdfad835f3e001b74d349c81c1d9f2f63b0MD52TEXTJOLiveira_CTDRibeiro_IOC_2001.pdf.txtJOLiveira_CTDRibeiro_IOC_2001.pdf.txtExtracted texttext/plain35394https://www.arca.fiocruz.br/bitstream/icict/44114/3/JOLiveira_CTDRibeiro_IOC_2001.pdf.txta4a6231a7a70b08e0be3bc93f6dd6df5MD53icict/441142020-10-23 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dc.title.pt_BR.fl_str_mv Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview
title Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview
spellingShingle Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview
Ferreira, J. Oliveira
Respostas de linfócitos T citotóxicos (CTL)
CTL e peptídeos auxiliares
Epítopos CD8 + e CD4 +
Vetores recombinantes
Partículas semelhantes a vírus Ty (VLP)
Cytotoxic T lymphocyte (CTL) responses
CTL and helper peptides
CD8+ and CD4+ epitopes
Recombinant vectors
Ty-virus like particles (VLP)
title_short Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview
title_full Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview
title_fullStr Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview
title_full_unstemmed Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview
title_sort Protective CD8+ T Cell Responses against the Pre-erythrocytic Stages of Malaria Parasites: an Overview
author Ferreira, J. Oliveira
author_facet Ferreira, J. Oliveira
Daniel-Ribeiro, Claudio Tadeu
author_role author
author2 Daniel-Ribeiro, Claudio Tadeu
author2_role author
dc.contributor.author.fl_str_mv Ferreira, J. Oliveira
Daniel-Ribeiro, Claudio Tadeu
dc.subject.other.pt_BR.fl_str_mv Respostas de linfócitos T citotóxicos (CTL)
CTL e peptídeos auxiliares
Epítopos CD8 + e CD4 +
Vetores recombinantes
Partículas semelhantes a vírus Ty (VLP)
topic Respostas de linfócitos T citotóxicos (CTL)
CTL e peptídeos auxiliares
Epítopos CD8 + e CD4 +
Vetores recombinantes
Partículas semelhantes a vírus Ty (VLP)
Cytotoxic T lymphocyte (CTL) responses
CTL and helper peptides
CD8+ and CD4+ epitopes
Recombinant vectors
Ty-virus like particles (VLP)
dc.subject.en.pt_BR.fl_str_mv Cytotoxic T lymphocyte (CTL) responses
CTL and helper peptides
CD8+ and CD4+ epitopes
Recombinant vectors
Ty-virus like particles (VLP)
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Centro Colaborador para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2020-10-22T14:22:58Z
dc.date.available.fl_str_mv 2020-10-22T14:22:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, J. Oliveira; DANIEL-RIBEIRO, Claudio Tadeu. Protective CD8+ T Cell Responses against the Preerythrocytic Stages of Malaria Parasites: an Overview. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 2, p. 221-227, Feb. 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44114
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762001000200014
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv FERREIRA, J. Oliveira; DANIEL-RIBEIRO, Claudio Tadeu. Protective CD8+ T Cell Responses against the Preerythrocytic Stages of Malaria Parasites: an Overview. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 2, p. 221-227, Feb. 2001.
0074-0276
10.1590/S0074-02762001000200014
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44114
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/44114/3/JOLiveira_CTDRibeiro_IOC_2001.pdf.txt
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