Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview

Detalhes bibliográficos
Autor(a) principal: Oliveira-Ferreira,J
Data de Publicação: 2001
Outros Autores: Daniel-Ribeiro,CT
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000200014
Resumo: CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocytic stage of malaria in mice and humans following irradiated sporozoite immunization. Immunization experiments in animal models by several investigators have suggested different strategies for vaccination against malaria and many of the targets from liver stage malaria antigens have been shown to be immunogenic and to protect mice from the sporozoite challenge. Several prime/boost protocols with replicating vectors, such as vaccinia/influenza, with non-replicating vectors, such as recombinant particles derived from yeast transposon (Ty-particles) and modified vaccinia virus Ankara, and DNA, significantly enhanced CD8+ T cell immunogenicity and also the protective efficacy against the circumsporosoite protein of Plasmodium berghei and P. yeti. Based on these experimental results the development of a CD8+ T cell inducing vaccine has moved forward from epitope identification to planning stages of safety and immunogenicity trials of candidate vaccines.
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spelling Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overviewmalariacytotoxic T lymphocyte (CTL) responsesCTL and helper peptidesCD8+ and CD4+ epitopesrecombinant vectorsTy-virus like particles (VLP)CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocytic stage of malaria in mice and humans following irradiated sporozoite immunization. Immunization experiments in animal models by several investigators have suggested different strategies for vaccination against malaria and many of the targets from liver stage malaria antigens have been shown to be immunogenic and to protect mice from the sporozoite challenge. Several prime/boost protocols with replicating vectors, such as vaccinia/influenza, with non-replicating vectors, such as recombinant particles derived from yeast transposon (Ty-particles) and modified vaccinia virus Ankara, and DNA, significantly enhanced CD8+ T cell immunogenicity and also the protective efficacy against the circumsporosoite protein of Plasmodium berghei and P. yeti. Based on these experimental results the development of a CD8+ T cell inducing vaccine has moved forward from epitope identification to planning stages of safety and immunogenicity trials of candidate vaccines.Instituto Oswaldo Cruz, Ministério da Saúde2001-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000200014Memórias do Instituto Oswaldo Cruz v.96 n.2 2001reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762001000200014info:eu-repo/semantics/openAccessOliveira-Ferreira,JDaniel-Ribeiro,CTeng2020-04-25T17:48:31Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:10:10.758Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview
title Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview
spellingShingle Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview
Oliveira-Ferreira,J
malaria
cytotoxic T lymphocyte (CTL) responses
CTL and helper peptides
CD8+ and CD4+ epitopes
recombinant vectors
Ty-virus like particles (VLP)
title_short Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview
title_full Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview
title_fullStr Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview
title_full_unstemmed Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview
title_sort Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview
author Oliveira-Ferreira,J
author_facet Oliveira-Ferreira,J
Daniel-Ribeiro,CT
author_role author
author2 Daniel-Ribeiro,CT
author2_role author
dc.contributor.author.fl_str_mv Oliveira-Ferreira,J
Daniel-Ribeiro,CT
dc.subject.por.fl_str_mv malaria
cytotoxic T lymphocyte (CTL) responses
CTL and helper peptides
CD8+ and CD4+ epitopes
recombinant vectors
Ty-virus like particles (VLP)
topic malaria
cytotoxic T lymphocyte (CTL) responses
CTL and helper peptides
CD8+ and CD4+ epitopes
recombinant vectors
Ty-virus like particles (VLP)
dc.description.none.fl_txt_mv CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocytic stage of malaria in mice and humans following irradiated sporozoite immunization. Immunization experiments in animal models by several investigators have suggested different strategies for vaccination against malaria and many of the targets from liver stage malaria antigens have been shown to be immunogenic and to protect mice from the sporozoite challenge. Several prime/boost protocols with replicating vectors, such as vaccinia/influenza, with non-replicating vectors, such as recombinant particles derived from yeast transposon (Ty-particles) and modified vaccinia virus Ankara, and DNA, significantly enhanced CD8+ T cell immunogenicity and also the protective efficacy against the circumsporosoite protein of Plasmodium berghei and P. yeti. Based on these experimental results the development of a CD8+ T cell inducing vaccine has moved forward from epitope identification to planning stages of safety and immunogenicity trials of candidate vaccines.
description CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocytic stage of malaria in mice and humans following irradiated sporozoite immunization. Immunization experiments in animal models by several investigators have suggested different strategies for vaccination against malaria and many of the targets from liver stage malaria antigens have been shown to be immunogenic and to protect mice from the sporozoite challenge. Several prime/boost protocols with replicating vectors, such as vaccinia/influenza, with non-replicating vectors, such as recombinant particles derived from yeast transposon (Ty-particles) and modified vaccinia virus Ankara, and DNA, significantly enhanced CD8+ T cell immunogenicity and also the protective efficacy against the circumsporosoite protein of Plasmodium berghei and P. yeti. Based on these experimental results the development of a CD8+ T cell inducing vaccine has moved forward from epitope identification to planning stages of safety and immunogenicity trials of candidate vaccines.
publishDate 2001
dc.date.none.fl_str_mv 2001-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000200014
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000200014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762001000200014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.96 n.2 2001
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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