Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57035 |
Resumo: | Fogarty International Center of the NIH. National Institute of Allergy and Infectious Diseases of the NIH. Yale School of Public Health Start-up funds. G4 group. Institut Pasteur de Paris e Agence Universitaire de la Francophonie. Burroughs Wellcome Fund Career Award for Medical Scientists. Ludwig Family Foundation. Mathers Charitable Foundation. Emergent Ventures fast Grant. National Center for Advancing Translational Science (NCATS). |
| id |
CRUZ_a8e98b4ceb5ac964b8ebbf51d2d25155 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/57035 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Lapidus, SarahLiu, FeimeiMassana, Arnau CasanovasDai, YileHuck, John D.Lucas, CarolinaKlein, JonFiller, Renata B.Strine, Madison S.Sy, MouhamadDeme, Awa B.Badiane, Aida S.Dieye, BabaNdiaye, Ibrahima MbayeDiedhiou, YounousMbaye, Amadou MoctarDiagne, Cheikh TidianeWomas, Ines ViganMbengue, AlassaneSadio, Bacary D.Diagne, Moussa M.Moore, Adam J.Mangou, KhadidiatouDiallo, FatoumataSene, Seynabou D.Pouye, Mariama N.Faye, RokhayaDiouf, BabacarNery Jr, NivisonCosta, FedericoReis, MitermayerMuenker, M. CatherineHodson, Daniel Z.Mbarga, YannickKatz, Ben Z.Andrews, Jason R.Campbell, MelissaSrivathsan, ArikthaKamath, KathyJones, Elisabeth BaumFaye, OusmaneSall, Amadou AlphaVelez, Juan Carlos QuinteroCappello, MichaelWilson, MichaelMamoun, Choukri BenTedder, RichardMcClure, MyraCherepanov, PeterSomé, Fabrice A.Dabiré, Roch K.Moukoko, Carole Else EboumbouOuédraogo, Jean BoscoYap, Boum IIShon, JohnNdiaye, DaoudaWisnewski, AdamParikh, SunilIwasaki, AkikoWilen, Craig B.Ko, Albert I.Ring, Aaron M.Bei, Amy K.2023-02-13T15:12:21Z2023-02-13T15:12:21Z2022LAPIDUS, Sarah et al. Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein. Scientific Reports, v. 12, p. 1-16, 2022.2045-2322https://www.arca.fiocruz.br/handle/icict/5703510.1038/s41598-022-26709-7Fogarty International Center of the NIH. National Institute of Allergy and Infectious Diseases of the NIH. Yale School of Public Health Start-up funds. G4 group. Institut Pasteur de Paris e Agence Universitaire de la Francophonie. Burroughs Wellcome Fund Career Award for Medical Scientists. Ludwig Family Foundation. Mathers Charitable Foundation. Emergent Ventures fast Grant. National Center for Advancing Translational Science (NCATS).Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA / Department of Laboratory Medicine. Yale School of Medicine. New Haven, CT, USA.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA / Department of Laboratory Medicine. Yale School of Medicine. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal.Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal.Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal.Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal.Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal.Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal.DiaTROPIX Rapid Diagnostic Tests Facility. Institut Pasteur de Dakar. Dakar, Senegal.Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.Pôle Virologie. Institut Pasteur de Dakar. Dakar, Senegal.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA.G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Department of Internal Medicine, Yale Occupational and Environmental Medicine Program. Yale School of Medicine. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA.Douala Military Hospital. Douala, Cameroon.Division of Infectious Diseases. Department of Pediatrics. Northwestern University Feinberg School of Medicine. Ann & Robert H. Lurie Children’s Hospital of Chicago. Chicago, USA.Division of Infectious Diseases and Geographic Medicine. School of Medicine. Stanford University. Stanford, CA, USA.Yale Center for Clinical Investigation. Yale School of Medicine. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA.Serimmune. Inc. Goleta, CA, USA.Serimmune. Inc. Goleta, CA, USA.Pôle Virologie. Institut Pasteur de Dakar. Dakar, Senegal.Pôle Virologie. Institut Pasteur de Dakar. Dakar, Senegal.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Grupo de Investigación Ciencias Veterinarias Centauro. University of Antioquia. Medellín, Colombia /Grupo de Investigación Microbiología Básica y aplicada. University of Antioquia. Medellín, Colombia.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Department of Pediatrics. Yale School of Medicine. New Haven, CT, USA.Department of Parasitology. Noguchi Memorial Institute for Medical Research. University of Ghana. Accra, Ghana.Department of Internal Medicine. Section of Infectious Diseases. Yale School of Medicine. New Haven, CT, USA.Department of Infectious Disease. Imperial College London. St Mary’s Campus. London, UK. / South London Specialist Virology Centre. Kings College Hospital NHS Foundation Trust. London, UK.Department of Infectious Disease. Imperial College London. St Mary’s Campus. London, UK.Department of Infectious Disease. Imperial College London. St Mary’s Campus. London, UK / Chromatin Structure and Mobile DNA Laboratory. The Francis Crick Institute. London, UK /Crick COVID19 Consortium. Francis Crick Institute. London, UK.Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz. Bobo Dioulasso. Burkina Faso.Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz. Bobo Dioulasso. Burkina Faso.Department of Biological Sciences. Faculty of Medicine and Pharmaceutical Sciences. University of Douala. Douala, BP, Cameroon / Malaria Research Unit. Center Pasteur Cameroon. Yaoundé, Cameroon.Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz. Bobo Dioulasso. Burkina Faso.Médecins Sans Frontières. University of Yaoundé and Epicentre. Yaoundé, Cameroon.Serimmune. Inc. Goleta, CA, USA.Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal.Department of Internal Medicine, Yale Occupational and Environmental Medicine Program. Yale School of Medicine. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA / Howard Hughes Medical Institute. Chevy Chase, MD, USA.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA.Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal / G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal.Sero-surveillance can monitor and project disease burden and risk. However, SARS-CoV-2 antibody test results can produce false positive results, limiting their efficacy as a sero-surveillance tool. False positive SARS-CoV-2 antibody results are associated with malaria exposure, and understanding this association is essential to interpret sero-surveillance results from malaria-endemic countries. Here, pre-pandemic samples from eight malaria endemic and non-endemic countries and four continents were tested by ELISA to measure SARS-CoV-2 Spike S1 subunit reactivity. Individuals with acute malaria infection generated substantial SARS-CoV-2 reactivity. Cross-reactivity was not associated with reactivity to other human coronaviruses or other SARS-CoV-2 proteins, as measured by peptide and protein arrays. ELISAs with deglycosylated and desialated Spike S1 subunits revealed that cross-reactive antibodies target sialic acid on N-linked glycans of the Spike protein. The functional activity of cross-reactive antibodies measured by neutralization assays showed that cross-reactive antibodies did not neutralize SARS-CoV-2 in vitro. Since routine use of glycosylated or sialated assays could result in false positive SARS-CoV-2 antibody results in malaria endemic regions, which could overestimate exposure and population-level immunity, we explored methods to increase specificity by reducing cross-reactivity. Overestimating population-level exposure to SARS-CoV-2 could lead to underestimates of risk of continued COVID-19 transmission in sub-Saharan Africa.engNature ResearchPlasmodiumInfecçãoAnticorposEpítopos de carboidratosSARS-CoV-2ProteínasPlasmodiumInfectionAntibodiescarbohydrate epitopesSARS‑CoV‑2ProteinPlasmodiumInfecçõesAnticorposEpítoposCarboidratosSARS-CoV-2ProteínasPlasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike proteininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57035/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLapidus, Sarah - Plasmodium infection is associated.pdfLapidus, Sarah - Plasmodium infection is associated.pdfapplication/pdf8036644https://www.arca.fiocruz.br/bitstream/icict/57035/2/Lapidus%2c%20Sarah%20-%20Plasmodium%20infection%20is%20associated.pdf34b77e97f4eb1f3845d1943906242966MD52icict/570352023-03-15 14:32:52.31oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein |
| title |
Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein |
| spellingShingle |
Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein Lapidus, Sarah Plasmodium Infecção Anticorpos Epítopos de carboidratos SARS-CoV-2 Proteínas Plasmodium Infection Antibodies carbohydrate epitopes SARS‑CoV‑2 Protein Plasmodium Infecções Anticorpos Epítopos Carboidratos SARS-CoV-2 Proteínas |
| title_short |
Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein |
| title_full |
Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein |
| title_fullStr |
Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein |
| title_full_unstemmed |
Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein |
| title_sort |
Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein |
| author |
Lapidus, Sarah |
| author_facet |
Lapidus, Sarah Liu, Feimei Massana, Arnau Casanovas Dai, Yile Huck, John D. Lucas, Carolina Klein, Jon Filler, Renata B. Strine, Madison S. Sy, Mouhamad Deme, Awa B. Badiane, Aida S. Dieye, Baba Ndiaye, Ibrahima Mbaye Diedhiou, Younous Mbaye, Amadou Moctar Diagne, Cheikh Tidiane Womas, Ines Vigan Mbengue, Alassane Sadio, Bacary D. Diagne, Moussa M. Moore, Adam J. Mangou, Khadidiatou Diallo, Fatoumata Sene, Seynabou D. Pouye, Mariama N. Faye, Rokhaya Diouf, Babacar Nery Jr, Nivison Costa, Federico Reis, Mitermayer Muenker, M. Catherine Hodson, Daniel Z. Mbarga, Yannick Katz, Ben Z. Andrews, Jason R. Campbell, Melissa Srivathsan, Ariktha Kamath, Kathy Jones, Elisabeth Baum Faye, Ousmane Sall, Amadou Alpha Velez, Juan Carlos Quintero Cappello, Michael Wilson, Michael Mamoun, Choukri Ben Tedder, Richard McClure, Myra Cherepanov, Peter Somé, Fabrice A. Dabiré, Roch K. Moukoko, Carole Else Eboumbou Ouédraogo, Jean Bosco Yap, Boum II Shon, John Ndiaye, Daouda Wisnewski, Adam Parikh, Sunil Iwasaki, Akiko Wilen, Craig B. Ko, Albert I. Ring, Aaron M. Bei, Amy K. |
| author_role |
author |
| author2 |
Liu, Feimei Massana, Arnau Casanovas Dai, Yile Huck, John D. Lucas, Carolina Klein, Jon Filler, Renata B. Strine, Madison S. Sy, Mouhamad Deme, Awa B. Badiane, Aida S. Dieye, Baba Ndiaye, Ibrahima Mbaye Diedhiou, Younous Mbaye, Amadou Moctar Diagne, Cheikh Tidiane Womas, Ines Vigan Mbengue, Alassane Sadio, Bacary D. Diagne, Moussa M. Moore, Adam J. Mangou, Khadidiatou Diallo, Fatoumata Sene, Seynabou D. Pouye, Mariama N. Faye, Rokhaya Diouf, Babacar Nery Jr, Nivison Costa, Federico Reis, Mitermayer Muenker, M. Catherine Hodson, Daniel Z. Mbarga, Yannick Katz, Ben Z. Andrews, Jason R. Campbell, Melissa Srivathsan, Ariktha Kamath, Kathy Jones, Elisabeth Baum Faye, Ousmane Sall, Amadou Alpha Velez, Juan Carlos Quintero Cappello, Michael Wilson, Michael Mamoun, Choukri Ben Tedder, Richard McClure, Myra Cherepanov, Peter Somé, Fabrice A. Dabiré, Roch K. Moukoko, Carole Else Eboumbou Ouédraogo, Jean Bosco Yap, Boum II Shon, John Ndiaye, Daouda Wisnewski, Adam Parikh, Sunil Iwasaki, Akiko Wilen, Craig B. Ko, Albert I. Ring, Aaron M. Bei, Amy K. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lapidus, Sarah Liu, Feimei Massana, Arnau Casanovas Dai, Yile Huck, John D. Lucas, Carolina Klein, Jon Filler, Renata B. Strine, Madison S. Sy, Mouhamad Deme, Awa B. Badiane, Aida S. Dieye, Baba Ndiaye, Ibrahima Mbaye Diedhiou, Younous Mbaye, Amadou Moctar Diagne, Cheikh Tidiane Womas, Ines Vigan Mbengue, Alassane Sadio, Bacary D. Diagne, Moussa M. Moore, Adam J. Mangou, Khadidiatou Diallo, Fatoumata Sene, Seynabou D. Pouye, Mariama N. Faye, Rokhaya Diouf, Babacar Nery Jr, Nivison Costa, Federico Reis, Mitermayer Muenker, M. Catherine Hodson, Daniel Z. Mbarga, Yannick Katz, Ben Z. Andrews, Jason R. Campbell, Melissa Srivathsan, Ariktha Kamath, Kathy Jones, Elisabeth Baum Faye, Ousmane Sall, Amadou Alpha Velez, Juan Carlos Quintero Cappello, Michael Wilson, Michael Mamoun, Choukri Ben Tedder, Richard McClure, Myra Cherepanov, Peter Somé, Fabrice A. Dabiré, Roch K. Moukoko, Carole Else Eboumbou Ouédraogo, Jean Bosco Yap, Boum II Shon, John Ndiaye, Daouda Wisnewski, Adam Parikh, Sunil Iwasaki, Akiko Wilen, Craig B. Ko, Albert I. Ring, Aaron M. Bei, Amy K. |
| dc.subject.other.en_US.fl_str_mv |
Plasmodium Infecção Anticorpos Epítopos de carboidratos SARS-CoV-2 Proteínas |
| topic |
Plasmodium Infecção Anticorpos Epítopos de carboidratos SARS-CoV-2 Proteínas Plasmodium Infection Antibodies carbohydrate epitopes SARS‑CoV‑2 Protein Plasmodium Infecções Anticorpos Epítopos Carboidratos SARS-CoV-2 Proteínas |
| dc.subject.en.en_US.fl_str_mv |
Plasmodium Infection Antibodies carbohydrate epitopes SARS‑CoV‑2 Protein |
| dc.subject.decs.en_US.fl_str_mv |
Plasmodium Infecções Anticorpos Epítopos Carboidratos SARS-CoV-2 Proteínas |
| description |
Fogarty International Center of the NIH. National Institute of Allergy and Infectious Diseases of the NIH. Yale School of Public Health Start-up funds. G4 group. Institut Pasteur de Paris e Agence Universitaire de la Francophonie. Burroughs Wellcome Fund Career Award for Medical Scientists. Ludwig Family Foundation. Mathers Charitable Foundation. Emergent Ventures fast Grant. National Center for Advancing Translational Science (NCATS). |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022 |
| dc.date.accessioned.fl_str_mv |
2023-02-13T15:12:21Z |
| dc.date.available.fl_str_mv |
2023-02-13T15:12:21Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
LAPIDUS, Sarah et al. Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein. Scientific Reports, v. 12, p. 1-16, 2022. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57035 |
| dc.identifier.issn.en_US.fl_str_mv |
2045-2322 |
| dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-022-26709-7 |
| identifier_str_mv |
LAPIDUS, Sarah et al. Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein. Scientific Reports, v. 12, p. 1-16, 2022. 2045-2322 10.1038/s41598-022-26709-7 |
| url |
https://www.arca.fiocruz.br/handle/icict/57035 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Nature Research |
| publisher.none.fl_str_mv |
Nature Research |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/57035/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/57035/2/Lapidus%2c%20Sarah%20-%20Plasmodium%20infection%20is%20associated.pdf |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 34b77e97f4eb1f3845d1943906242966 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009128440725504 |