Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals

Detalhes bibliográficos
Autor(a) principal: Paixão, Ariane Gomes
Data de Publicação: 2023
Outros Autores: Almeida, Marcos Abreu, Correia, Roberta Espírito Santo, Kamiensky, Beatriz Brittes, Zancopé-Oliveira, Rosely Maria, Lazera, Márcia dos Santos, Wanke, Bodo, Lamas, Cristiane da Cruz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3390/tropicalmed8050271
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60237
Resumo: Institutional Review Board Statement: The study was approved by the INI Research Ethics Committee; under CAAE number 98094718.4.0000.5262, on 10 December 2018. Informed Consent Statement: This is a retrospective study and our local Ethics Committee approved it without the need for informed consent. Data Availability Statement: Data has not been made publicly available due to ethical reasons. Acknowledgments: We thank Julio Castro Alves de Lima e Silva for statistical analysis, and we thank all colleagues involved in patient care.
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spelling Paixão, Ariane GomesAlmeida, Marcos AbreuCorreia, Roberta Espírito SantoKamiensky, Beatriz BrittesZancopé-Oliveira, Rosely MariaLazera, Márcia dos SantosWanke, BodoLamas, Cristiane da Cruz2023-08-26T15:24:35Z2023-08-26T15:24:35Z2023PAIXÃO, Ariane Gomes et al. Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals. Tropical Medicine and Infectious Disease, v. 8, p. 1-11, Apr. 2023.2414-6366https://www.arca.fiocruz.br/handle/icict/6023710.3390/tropicalmed8050271Institutional Review Board Statement: The study was approved by the INI Research Ethics Committee; under CAAE number 98094718.4.0000.5262, on 10 December 2018. Informed Consent Statement: This is a retrospective study and our local Ethics Committee approved it without the need for informed consent. Data Availability Statement: Data has not been made publicly available due to ethical reasons. Acknowledgments: We thank Julio Castro Alves de Lima e Silva for statistical analysis, and we thank all colleagues involved in patient care.RMZ-O is partially supported by grants from CNPq 308315/2021-9 and FAPERJ E-26/200.381/2023.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brazil.Objectives: Histoplasmosis is a systemic mycosis, present globally. We aimed to describe cases of histoplasmosis (Hc) and to establish a risk profile associated with Hc in HIV-infected patients (HIV+). Methods: This was a retrospective study of patients with a clinical laboratory diagnosis of Hc. Data were fed into REDCap, and statistical analysis was performed with R. Results: We included 99 records, 65 HIV+ and 34 HIV−. Average age was 39 years. Median time from onset to diagnosis was 8 weeks in HIV− and 22 weeks in HIV+. Disseminated histoplasmosis occurred in 79.4% of HIV+, vs. 36.4% of HIV− patients. Median CD4 count was 70. Co-infection with tuberculosis was present in 20% of HIV+ patients. Blood cultures were positive in 32.3% of HIV+ vs. 11.8% of HIV−(p = 0.025) patients; bone marrow culture was positive in 36.9% vs. 8.8% (p = 0.003). Most HIV+ patients (71.4%) were hospitalized. On univariate analysis, anemia, leukopenia, intensive care, use of vasopressors and mechanical ventilation were associated with death in HIV+ patients. Conclusions: Most of our patients with histoplasmosis were HIV+, presenting advanced AIDS. Diagnosis was late in HIV+ patients, and they frequently presented disseminated Hc, required hospitalization, and died. Early screening for Hc in HIV+ and drug-induced immunosuppressed patients is crucial.engMDPIHistoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHistoplasmosisBrazilEpidemiologyHIV-positiveAIDSImmunosuppressionCultureSerologyMortalityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60237/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Ariane_Paixão_etal_INI_2023.pdfve_Ariane_Paixão_etal_INI_2023.pdfapplication/pdf631492https://www.arca.fiocruz.br/bitstream/icict/60237/2/ve_Ariane_Paix%c3%a3o_etal_INI_2023.pdf2c9b9516fdfe871290ec0229e443a9bbMD52icict/602372023-08-26 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dc.title.en_US.fl_str_mv Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals
title Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals
spellingShingle Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals
Paixão, Ariane Gomes
Histoplasmosis
Brazil
Epidemiology
HIV-positive
AIDS
Immunosuppression
Culture
Serology
Mortality
title_short Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals
title_full Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals
title_fullStr Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals
title_full_unstemmed Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals
title_sort Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals
author Paixão, Ariane Gomes
author_facet Paixão, Ariane Gomes
Almeida, Marcos Abreu
Correia, Roberta Espírito Santo
Kamiensky, Beatriz Brittes
Zancopé-Oliveira, Rosely Maria
Lazera, Márcia dos Santos
Wanke, Bodo
Lamas, Cristiane da Cruz
author_role author
author2 Almeida, Marcos Abreu
Correia, Roberta Espírito Santo
Kamiensky, Beatriz Brittes
Zancopé-Oliveira, Rosely Maria
Lazera, Márcia dos Santos
Wanke, Bodo
Lamas, Cristiane da Cruz
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paixão, Ariane Gomes
Almeida, Marcos Abreu
Correia, Roberta Espírito Santo
Kamiensky, Beatriz Brittes
Zancopé-Oliveira, Rosely Maria
Lazera, Márcia dos Santos
Wanke, Bodo
Lamas, Cristiane da Cruz
dc.subject.en.en_US.fl_str_mv Histoplasmosis
Brazil
Epidemiology
HIV-positive
AIDS
Immunosuppression
Culture
Serology
Mortality
topic Histoplasmosis
Brazil
Epidemiology
HIV-positive
AIDS
Immunosuppression
Culture
Serology
Mortality
description Institutional Review Board Statement: The study was approved by the INI Research Ethics Committee; under CAAE number 98094718.4.0000.5262, on 10 December 2018. Informed Consent Statement: This is a retrospective study and our local Ethics Committee approved it without the need for informed consent. Data Availability Statement: Data has not been made publicly available due to ethical reasons. Acknowledgments: We thank Julio Castro Alves de Lima e Silva for statistical analysis, and we thank all colleagues involved in patient care.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-26T15:24:35Z
dc.date.available.fl_str_mv 2023-08-26T15:24:35Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAIXÃO, Ariane Gomes et al. Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals. Tropical Medicine and Infectious Disease, v. 8, p. 1-11, Apr. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60237
dc.identifier.issn.en_US.fl_str_mv 2414-6366
dc.identifier.doi.none.fl_str_mv 10.3390/tropicalmed8050271
identifier_str_mv PAIXÃO, Ariane Gomes et al. Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals. Tropical Medicine and Infectious Disease, v. 8, p. 1-11, Apr. 2023.
2414-6366
10.3390/tropicalmed8050271
url https://www.arca.fiocruz.br/handle/icict/60237
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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https://www.arca.fiocruz.br/bitstream/icict/60237/2/ve_Ariane_Paix%c3%a3o_etal_INI_2023.pdf
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