Immunolocalisation of laminin-1 in keratocystic odontogenic tumors

Detalhes bibliográficos
Autor(a) principal: Gurgel, Clarissa Araújo Silva
Data de Publicação: 2010
Outros Autores: Ramos, Eduardo Antônio Gonçalves, Melo, Leonardo de Araújo, Schlaepfer, Caroline Brandi, Souza, Renata Oliveira de, Oliveira, Márcio Campos, Santos, Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6064
Resumo: Trabalho completo: acesso restrito,p. 624–629
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spelling Gurgel, Clarissa Araújo SilvaRamos, Eduardo Antônio GonçalvesMelo, Leonardo de AraújoSchlaepfer, Caroline BrandiSouza, Renata Oliveira deOliveira, Márcio CamposSantos, Jean Nunes dosGurgel, Clarissa Araújo SilvaRamos, Eduardo Antônio GonçalvesMelo, Leonardo de AraújoSchlaepfer, Caroline BrandiSouza, Renata Oliveira deOliveira, Márcio CamposSantos, Jean Nunes dos2012-06-04T18:30:40Z20100065-1281http://www.repositorio.ufba.br/ri/handle/ri/6064v. 112, n. 6Trabalho completo: acesso restrito,p. 624–629Keratocystic odontogenic tumors (KOTs) are distinct odontogenic lesions frequently affecting the jawbones. They may be associated with nevoid basal cell carcinoma syndrome (NBCCS), and may exhibit disorders involving the extracellular matrix. The aim of this study was to investigate the immunolocalisation of laminin-1 in 20 cases of KOTs in order to contribute to the characterization of this protein, which is little studied in odontogenic tumors. Our results showed laminin-1 in all 20 KOTs studied; its labelling intensity was weak in three cases (15%), moderate in five (25%) and strong in 12 cases (60%). Laminin-1 immunolocalisation was predominantly continuous in 18 (90%) KOTs, including areas of acanthosis, subepithelial split and epithelial buds. Weak immunolabelling was observed in regions exhibiting an inflammatory process, especially in the case of intense inflammation. These findings suggest that laminin-1 does not participate in biological processes such as cystic epithelium-cystic wall separation or the formation of epithelial islands in KOTs. Furthermore, the discontinuous and weak labelling of this protein in the basement membrane of these tumors is probably a consequence of the inflammatory process in the tumor stroma.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-06-04T18:30:39Z No. of bitstreams: 1 (54)1-s2.0-S0065128109000713-main.pdf: 614189 bytes, checksum: 2b3517ce8f70091e4d76db96b5692a1b (MD5)Made available in DSpace on 2012-06-04T18:30:40Z (GMT). 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dc.title.pt_BR.fl_str_mv Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
dc.title.alternative.pt_BR.fl_str_mv Acta Histochemica
title Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
spellingShingle Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
Gurgel, Clarissa Araújo Silva
Keratocystic odontogenic tumors
Laminin-1
Immunohistochemistry
title_short Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
title_full Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
title_fullStr Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
title_full_unstemmed Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
title_sort Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
author Gurgel, Clarissa Araújo Silva
author_facet Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Melo, Leonardo de Araújo
Schlaepfer, Caroline Brandi
Souza, Renata Oliveira de
Oliveira, Márcio Campos
Santos, Jean Nunes dos
author_role author
author2 Ramos, Eduardo Antônio Gonçalves
Melo, Leonardo de Araújo
Schlaepfer, Caroline Brandi
Souza, Renata Oliveira de
Oliveira, Márcio Campos
Santos, Jean Nunes dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Melo, Leonardo de Araújo
Schlaepfer, Caroline Brandi
Souza, Renata Oliveira de
Oliveira, Márcio Campos
Santos, Jean Nunes dos
Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Melo, Leonardo de Araújo
Schlaepfer, Caroline Brandi
Souza, Renata Oliveira de
Oliveira, Márcio Campos
Santos, Jean Nunes dos
dc.subject.por.fl_str_mv Keratocystic odontogenic tumors
Laminin-1
Immunohistochemistry
topic Keratocystic odontogenic tumors
Laminin-1
Immunohistochemistry
description Trabalho completo: acesso restrito,p. 624–629
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-06-04T18:30:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6064
dc.identifier.issn.none.fl_str_mv 0065-1281
dc.identifier.number.pt_BR.fl_str_mv v. 112, n. 6
identifier_str_mv 0065-1281
v. 112, n. 6
url http://www.repositorio.ufba.br/ri/handle/ri/6064
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.acthis.2009.06.006
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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