Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14944 |
Resumo: | Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil / Universidade Federal de Rondônia. Porto Velho, RO, Brasil. |
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Costa, Joana D’Arc NevesZanchi, Fernando BertonRodrigues, Francisco Lurdevanhe da SilvaHonda, Eduardo RezendeKatsuragawa, Tony HiroschiPereira, Dhélio BatistaTaborda, Roger Lafontaine MesquitaTada, Mauro ShugiroFerreira, Ricardo de Godoi MattosPereira-da-Silva, Luiz Hildebrando2016-07-14T15:32:27Z2016-07-15T18:40:36Z2016-07-14T15:32:27Z2016-07-15T18:40:36Z2013COSTA, Joana D’Arc Neves et al. Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 1, p. 98-105, Feb. 2013.https://www.arca.fiocruz.br/handle/icict/1494410.1590/S0074-02762013000100016engFundação Oswaldo CruzCross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivaxinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCentro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil / Universidade Federal de Rondônia. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Fiocruz Rondônia. Instituto de Pesquisas em Patologias Tropicais. Porto Velho, RO, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Fiocruz Rondônia. Instituto de Pesquisas em Patologias Tropicais. Porto Velho, RO, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil / Universidade Federal de Rondônia. Porto Velho, RO, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil / Fundação Oswaldo Cruz. Fiocruz Rondônia. Instituto de Pesquisas em Patologias Tropicais. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Fiocruz Rondônia. Instituto de Pesquisas em Patologias Tropicais. Porto Velho, RO, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil / Fundação Oswaldo Cruz. Fiocruz Rondônia. Instituto de Pesquisas em Patologias Tropicais. Porto Velho, RO, Brasil.The PfCLAG9 has been extensively studied because their immunogenicity. Thereby, the gene product is important for therapeutics interventions and a potential vaccine candidate. Antibodies against synthetic peptides corresponding to selected sequences of the Plasmodium falciparum antigen PfCLAG9 were found in sera of falciparum malaria patients from Rondônia, in the Brazilian Amazon. Much higher antibody titres were found in semi-immune and immune asymptomatic parasite carriers than in subjects suffering clinical infections, corroborating original findings in Papua Guinea. However, sera of Plasmodium vivax patients from the same Amazon area, in particular from asymptomatic vivax parasite carriers, reacted strongly with the same peptides. Bioinformatic analyses revealed regions of similarity between P. falciparum Pfclag9 and the P. vivax ortholog Pvclag7. Indirect fluorescent microscopy analysis showed that antibodies against PfCLAG9 peptides elicited in BALB/c mice react with human red blood cells (RBCs) infected with both P. falciparum and P. vivax parasites. The patterns of reactivity on the surface of the parasitised RBCs are very similar. The present observations support previous findings that PfClag9 may be a target of protective immune responses and raises the possibility that the cross reactive antibodies to PvCLAG7 in mixed infections play a role in regulate the fate of Plasmodium mixed infections.MalariaImmunityAmazonCross-reactioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTCross-reactive anti-PfCLAG9.pdf.txtCross-reactive anti-PfCLAG9.pdf.txtExtracted texttext/plain39798https://www.arca.fiocruz.br/bitstream/icict/14944/4/Cross-reactive%20anti-PfCLAG9.pdf.txt0239dd87d08632acfc502eb84feeeb5cMD54ORIGINALCross-reactive anti-PfCLAG9.pdfapplication/pdf858856https://www.arca.fiocruz.br/bitstream/icict/14944/2/Cross-reactive%20anti-PfCLAG9.pdf2ffe44623a0b886c451e6b51473c40a8MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14944/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/149442019-04-25 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| dc.title.pt_BR.fl_str_mv |
Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax |
| title |
Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax |
| spellingShingle |
Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax Costa, Joana D’Arc Neves Malaria Immunity Amazon Cross-reaction |
| title_short |
Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax |
| title_full |
Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax |
| title_fullStr |
Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax |
| title_full_unstemmed |
Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax |
| title_sort |
Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax |
| author |
Costa, Joana D’Arc Neves |
| author_facet |
Costa, Joana D’Arc Neves Zanchi, Fernando Berton Rodrigues, Francisco Lurdevanhe da Silva Honda, Eduardo Rezende Katsuragawa, Tony Hiroschi Pereira, Dhélio Batista Taborda, Roger Lafontaine Mesquita Tada, Mauro Shugiro Ferreira, Ricardo de Godoi Mattos Pereira-da-Silva, Luiz Hildebrando |
| author_role |
author |
| author2 |
Zanchi, Fernando Berton Rodrigues, Francisco Lurdevanhe da Silva Honda, Eduardo Rezende Katsuragawa, Tony Hiroschi Pereira, Dhélio Batista Taborda, Roger Lafontaine Mesquita Tada, Mauro Shugiro Ferreira, Ricardo de Godoi Mattos Pereira-da-Silva, Luiz Hildebrando |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Joana D’Arc Neves Zanchi, Fernando Berton Rodrigues, Francisco Lurdevanhe da Silva Honda, Eduardo Rezende Katsuragawa, Tony Hiroschi Pereira, Dhélio Batista Taborda, Roger Lafontaine Mesquita Tada, Mauro Shugiro Ferreira, Ricardo de Godoi Mattos Pereira-da-Silva, Luiz Hildebrando |
| dc.subject.en.eng.fl_str_mv |
Malaria Immunity Amazon Cross-reaction |
| topic |
Malaria Immunity Amazon Cross-reaction |
| description |
Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil / Universidade Federal de Rondônia. Porto Velho, RO, Brasil. |
| publishDate |
2013 |
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2013 |
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2016-07-14T15:32:27Z 2016-07-15T18:40:36Z |
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2016-07-14T15:32:27Z 2016-07-15T18:40:36Z |
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COSTA, Joana D’Arc Neves et al. Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 1, p. 98-105, Feb. 2013. |
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https://www.arca.fiocruz.br/handle/icict/14944 |
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10.1590/S0074-02762013000100016 |
| identifier_str_mv |
COSTA, Joana D’Arc Neves et al. Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 1, p. 98-105, Feb. 2013. 10.1590/S0074-02762013000100016 |
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