HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Azevedo, Suwellen Sardinha Dias de
Data de Publicação: 2022
Outros Autores: Delatorre, Edson, Gaido, Cibele Marina, Jesus, Carlos Silva de, Guimarães, Monick Lindenmeyer, Couto-Fernandez, José Carlos, Morgado, Mariza G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55171
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Azevedo, Suwellen Sardinha Dias deDelatorre, EdsonGaido, Cibele MarinaJesus, Carlos Silva deGuimarães, Monick LindenmeyerCouto-Fernandez, José CarlosMorgado, Mariza G.2022-10-16T20:28:09Z2022-10-16T20:28:09Z2022AZEVEDO, Suwellen Sardinha Dias de Azevedo et al. HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil. Viruses, v. 14, 1761, p. 1 - 16, Aug. 2022.1999-4915https://www.arca.fiocruz.br/handle/icict/5517110.3390/ v14081761engMDPIBrasilCriançasHIV-1DiversidadeMutações de resistênciaBrazilChildrenHIV-1DiversityResistance mutationsHIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Espírito Santo—UFES. Centro de Ciências Exatas, Naturais e da Saúde. Departamento de Biologia. Vitória. ES, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.The human immunodeficiency virus type 1 (HIV-1) can be transmitted via parenteral, sexual, or vertical exposure routes. The number of HIV-1 cases detected yearly in children and adolescents in Brazil did not decrease over the last decade, representing ~5% of total cases described in the country. In recent years, the HIV-1 diversity and the prevalence of transmitted drug resistance mutations (TDRM) are moving toward a marked increase. In this study, we retrospectively evaluated the diversity of HIV-1 subtypes and the TDRM prevalence in 135 treatment-naïve HIV-1 vertically infected children and adolescents born in between 1993 and 2012. These children were assessed in either 2001–2007 or 2008–2012 when they were 0 to 17 years old. The individuals assessed in 2001–2007 (n = 38) had median CD4+ T cell counts of 1218 cells/mm3 (IQR: 738–2.084) and median HIV-1 plasma viral load of 4.18 log10 copies/mL (IQR: 3.88–4.08). The individuals (n = 97) evaluated in 2008–2012 showed median CD4+ T cell counts of 898.5 cells/mm3 (IQR: 591.3–1.821) and median HIV-1 plasma viral load of 4.69 log10 copies/mL (IQR: 4.26–5.33). A steady decrease in the median CD4 T+ cell counts was observed with age progression, as expected. The majority HIV-1 pol sequences (87%) were classified as pure HIV-1 subtypes (77% subtype B, 9% subtype F1 and 1.5% subtype C), while 13% of sequences were classified as recombinants (CRF45_cpx, n = 4; CRF28/29_BF1, n = 2; CRF02_AG, n = 1; CRF40_BF1, n = 1, CRF99_BF1, n = 1, URF_BF1, n = 8). The overall prevalence of TDRM was 14% (19/135), conferring resistance to the nucleoside reverse transcriptase inhibitors (NRTI, 13/135–9.6%), non-nucleoside reverse transcriptase inhibitors (NNRTI, 8/135–5.9%), and protease inhibitors (PI, 2/135–1.5%). The main TDRM observed for NNRTI was the K103N (n = 8), while the mutations T215I/Y/D/E (n = 7) and M184V (n = 4) were the main TDRM for NRTI. Only two TDRM were observed for PI in one individual each (M46I and V82A). Most TDRM were found in the HIV-1 subtype B (84%) sequences. This study reveals an HIV-1 epidemic with high diversity and moderate prevalence of TDRM in the pediatric population of Rio de Janeiro, indicating the existence of possible problems in the clinical management of prophylactic therapy to prevent mother-to-child transmission and future treatment options for the affected children.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55171/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALviruses-14-01761.pdfviruses-14-01761.pdfapplication/pdf1054331https://www.arca.fiocruz.br/bitstream/icict/55171/2/viruses-14-01761.pdf8b122c63d98eba50ef070c848604f9cbMD52icict/551712023-09-14 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dc.title.en_US.fl_str_mv HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil
title HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil
spellingShingle HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil
Azevedo, Suwellen Sardinha Dias de
Brasil
Crianças
HIV-1
Diversidade
Mutações de resistência
Brazil
Children
HIV-1
Diversity
Resistance mutations
title_short HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil
title_full HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil
title_fullStr HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil
title_full_unstemmed HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil
title_sort HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil
author Azevedo, Suwellen Sardinha Dias de
author_facet Azevedo, Suwellen Sardinha Dias de
Delatorre, Edson
Gaido, Cibele Marina
Jesus, Carlos Silva de
Guimarães, Monick Lindenmeyer
Couto-Fernandez, José Carlos
Morgado, Mariza G.
author_role author
author2 Delatorre, Edson
Gaido, Cibele Marina
Jesus, Carlos Silva de
Guimarães, Monick Lindenmeyer
Couto-Fernandez, José Carlos
Morgado, Mariza G.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Azevedo, Suwellen Sardinha Dias de
Delatorre, Edson
Gaido, Cibele Marina
Jesus, Carlos Silva de
Guimarães, Monick Lindenmeyer
Couto-Fernandez, José Carlos
Morgado, Mariza G.
dc.subject.other.en_US.fl_str_mv Brasil
Crianças
HIV-1
Diversidade
Mutações de resistência
topic Brasil
Crianças
HIV-1
Diversidade
Mutações de resistência
Brazil
Children
HIV-1
Diversity
Resistance mutations
dc.subject.en.en_US.fl_str_mv Brazil
Children
HIV-1
Diversity
Resistance mutations
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-16T20:28:09Z
dc.date.available.fl_str_mv 2022-10-16T20:28:09Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AZEVEDO, Suwellen Sardinha Dias de Azevedo et al. HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil. Viruses, v. 14, 1761, p. 1 - 16, Aug. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55171
dc.identifier.issn.en_US.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/ v14081761
identifier_str_mv AZEVEDO, Suwellen Sardinha Dias de Azevedo et al. HIV-1 Diversity and Drug Resistance in Treatment-Naïve Children and Adolescents from Rio de Janeiro, Brazil. Viruses, v. 14, 1761, p. 1 - 16, Aug. 2022.
1999-4915
10.3390/ v14081761
url https://www.arca.fiocruz.br/handle/icict/55171
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55171/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55171/2/viruses-14-01761.pdf
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