Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study

Detalhes bibliográficos
Autor(a) principal: Collet, Marie O.
Data de Publicação: 2018
Outros Autores: Caballero, Jesús, Sonneville, Romain, Bozza, Fernando A., Nydahl, Peter, Schandl, Anna, Wøien, Hilden, Citerio, Giuseppe, Boogaard, Mark van den, Hästbacka, Johanna, Haenggi, Matthias, Colpaert, Kirsten, Rose, Louise, Barbateskovic, Marija, Lange, Theis, Jensen, Aksel, Krog, Martin B., Egerod, Ingrid, Nibro, Helle L., Wetterslev, Jørn, Perner, Anders
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33988
Resumo: 2020-07-11
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spelling Collet, Marie O.Caballero, JesúsSonneville, RomainBozza, Fernando A.Nydahl, PeterSchandl, AnnaWøien, HildenCiterio, GiuseppeBoogaard, Mark van denHästbacka, JohannaHaenggi, MatthiasColpaert, KirstenRose, LouiseBarbateskovic, MarijaLange, TheisJensen, AkselKrog, Martin B.Egerod, IngridNibro, Helle L.Wetterslev, JørnPerner, Anders2019-07-11T15:20:07Z2019-07-11T15:20:07Z2018COLLET, Marie O. et al. Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. Intensive Care Medicine, v. 44, p. 1081-1089, 2018.0342-4642https://www.arca.fiocruz.br/handle/icict/3398810.1007/s00134-018-5204-y1432-1238engSpringerPrevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-07-11Copenhagen University Hospital. Rigshospitalet. Department of Intensive Care. Copenhagen, Denmark / Centre for Research in Intensive Care. Copenhagen, Denmark.Hospital Universitari Arnau de Vilanova. IRB Lleida. Lleida, Spain / Hospital Universitari Vall d’Hebron. Barcelona, Spain / Universitat Autònoma de Barcelona. Barcelona, Spain.Assistance publique–Hôpitaux de Paris. Bichat Claude Bernard Hospital. Department of Intensive Care Medicine and Infectious Diseases. Paris, France / Sorbonne Paris Cité. Inserm. UMR1148, LVTS. Paris, France / Paris Diderot University, Paris, France.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University Hospital of Schleswig-Holstein. Department of Nursing Research. Kiel, Germany / University Hospital of Schleswig-Holstein. Department of Anaesthesiology and Intensive Care Medicine. Kiel, Germany.Karolinska University Hospital. Department of Perioperative Medicine and Intensive Care. Stockholm, Sweden.Oslo University Hospital. Division of Emergencies and Intensive Care. Oslo, Norway.University of Milano Bicocca. School of Medicine and Surgery. Neuroanaesthesia and Neurointensive Care. Milan, Italy / H. San Gerardo Monza, Italy.Radboud University Medical Center. Department Intensive Care Medicine. Nijmegen, The Netherlands.University of Helsinki. Helsinki University Hospital. Department of Anaesthesia, Intensive Care and Pain Medicine. Division of Intensive Care. Helsinki, Finland.University of Bern. University Hospital Bern. Department of Intensive Care Medicine. Bern, Switzerland.University Hospital Gent. Intensive Care Unit. Ghent, Belgium.Sunnybrook Health Sciences Centre. Department of Critical Care Medicine. Toronto, ON, Canada / King’s College London. Florence Nightingale Faculty of Nursing, Midwife and Palliative Care. London, UK.Centre for Research in Intensive Care. Copenhagen, Denmark / Copenhagen University Hospital. Rigshospitalet. Copenhagen Trial Unit. Copenhagen, Denmark.Centre for Research in Intensive Care. Copenhagen, Denmark / University of Copenhagen. Department of Public Health. Section of Biostatistics. Copenhagen, Denmark / Peking University.Centre for Research in Intensive Care. Copenhagen, Denmark / University of Copenhagen. Department of Public Health. Section of Biostatistics. Copenhagen, Denmark. Centre for Statistical Science. Beijing, China.University Hospital Aarhus. Department of Intensive Care. Aarhus, Denmark.Copenhagen University Hospital. Rigshospitalet. Department of Intensive Care. Copenhagen, Denmark / Centre for Research in Intensive Care. Copenhagen, Denmark.Centre for Research in Intensive Care. Copenhagen, Denmark / University Hospital Aarhus. Department of Intensive Care. Aarhus, Denmark.Centre for Research in Intensive Care. Copenhagen, Denmark / Centre for Research in Intensive Care. Copenhagen, Denmark.Copenhagen University Hospital. Rigshospitalet. Department of Intensive Care. Copenhagen, Denmark / Centre for Research in Intensive Care. Copenhagen, Denmark.Purpose: We assessed the prevalence and variables associated with haloperidol use for delirium in ICU patients and explored any associations of haloperidol use with 90-day mortality. Methods: All acutely admitted, adult ICU patients were screened during a 2-week inception period. We followed the patient throughout their ICU stay and assessed 90-day mortality. We assessed patients and their variables in the first 24 and 72h in ICU and studied their association together with that of ICU characteristics with haloperidol use. Results: We included 1260 patients from 99 ICUs in 13 countries. Delirium occurred in 314/1260 patients [25% (95% confidence interval 23–27)] of whom 145 received haloperidol [46% (41–52)]. Other interventions for delirium were benzodiazepines in 36% (31–42), dexmedetomidine in 21% (17–26), quetiapine in 19% (14–23) and olanzapine in 9% (6–12) of the patients with delirium. In the frst 24 h in the ICU, all subtypes of delirium [hyperactive, adjusted odds ratio (aOR) 29.7 (12.9–74.5); mixed 10.0 (5.0–20.2); hypoactive 3.0 (1.2–6.7)] and circulatory support 2.7 (1.7–4.3) were associated with haloperidol use. At 72 h after ICU admission, circulatory support remained associated with subsequent use of haloperidol, aOR 2.6 (1.1–6.9). Haloperidol use within 0–24 h and within 0–72 h of ICU admission was not associated with 90-day mortality [aOR 1.2 (0.5–2.5); p=0.66] and [aOR 1.9 (1.0–3.9); p=0.07], respectively. Conclusions: In our study, haloperidol was the main pharmacological agent used for delirium in adult patients regardless of delirium subtype. Benzodiazepines, other anti-psychotics and dexmedetomidine were other frequently used agents. Haloperidol use was not statistically signifcantly associated with increased 90-day mortality.DeliriumICUHaloperidolCohortCritical careinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33988/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Collet_Marie_etal_INI_2018.pdfve_Collet_Marie_etal_INI_2018.pdfapplication/pdf1060702https://www.arca.fiocruz.br/bitstream/icict/33988/2/ve_Collet_Marie_etal_INI_2018.pdf26e01ee9f6db3ccefcfa18d58617f56aMD52TEXTve_Collet_Marie_etal_INI_2018.pdf.txtve_Collet_Marie_etal_INI_2018.pdf.txtExtracted texttext/plain43232https://www.arca.fiocruz.br/bitstream/icict/33988/3/ve_Collet_Marie_etal_INI_2018.pdf.txtc1b36ddbcece175e32a325d7a52599a9MD53icict/339882021-03-24 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dc.title.pt_BR.fl_str_mv Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study
title Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study
spellingShingle Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study
Collet, Marie O.
Delirium
ICU
Haloperidol
Cohort
Critical care
title_short Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study
title_full Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study
title_fullStr Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study
title_full_unstemmed Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study
title_sort Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study
author Collet, Marie O.
author_facet Collet, Marie O.
Caballero, Jesús
Sonneville, Romain
Bozza, Fernando A.
Nydahl, Peter
Schandl, Anna
Wøien, Hilden
Citerio, Giuseppe
Boogaard, Mark van den
Hästbacka, Johanna
Haenggi, Matthias
Colpaert, Kirsten
Rose, Louise
Barbateskovic, Marija
Lange, Theis
Jensen, Aksel
Krog, Martin B.
Egerod, Ingrid
Nibro, Helle L.
Wetterslev, Jørn
Perner, Anders
author_role author
author2 Caballero, Jesús
Sonneville, Romain
Bozza, Fernando A.
Nydahl, Peter
Schandl, Anna
Wøien, Hilden
Citerio, Giuseppe
Boogaard, Mark van den
Hästbacka, Johanna
Haenggi, Matthias
Colpaert, Kirsten
Rose, Louise
Barbateskovic, Marija
Lange, Theis
Jensen, Aksel
Krog, Martin B.
Egerod, Ingrid
Nibro, Helle L.
Wetterslev, Jørn
Perner, Anders
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Collet, Marie O.
Caballero, Jesús
Sonneville, Romain
Bozza, Fernando A.
Nydahl, Peter
Schandl, Anna
Wøien, Hilden
Citerio, Giuseppe
Boogaard, Mark van den
Hästbacka, Johanna
Haenggi, Matthias
Colpaert, Kirsten
Rose, Louise
Barbateskovic, Marija
Lange, Theis
Jensen, Aksel
Krog, Martin B.
Egerod, Ingrid
Nibro, Helle L.
Wetterslev, Jørn
Perner, Anders
dc.subject.en.pt_BR.fl_str_mv Delirium
ICU
Haloperidol
Cohort
Critical care
topic Delirium
ICU
Haloperidol
Cohort
Critical care
description 2020-07-11
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-07-11T15:20:07Z
dc.date.available.fl_str_mv 2019-07-11T15:20:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COLLET, Marie O. et al. Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. Intensive Care Medicine, v. 44, p. 1081-1089, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33988
dc.identifier.issn.pt_BR.fl_str_mv 0342-4642
dc.identifier.doi.none.fl_str_mv 10.1007/s00134-018-5204-y
dc.identifier.eissn.none.fl_str_mv 1432-1238
identifier_str_mv COLLET, Marie O. et al. Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study. Intensive Care Medicine, v. 44, p. 1081-1089, 2018.
0342-4642
10.1007/s00134-018-5204-y
1432-1238
url https://www.arca.fiocruz.br/handle/icict/33988
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33988/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33988/2/ve_Collet_Marie_etal_INI_2018.pdf
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