Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes

Detalhes bibliográficos
Autor(a) principal: Mello, Francisco Campello do Amaral
Data de Publicação: 2012
Outros Autores: Fernandes, Carlos Augusto, Gomes, Selma de Andrade
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18817
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecularl. Rio de Janeiro, RJ. Brasil.
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spelling Mello, Francisco Campello do AmaralFernandes, Carlos AugustoGomes, Selma de Andrade2017-05-11T14:08:54Z2017-05-11T14:08:54Z2012MELLO, Francisco Campello do Amaral; FERNANDES, Carlos Augusto; GOMES, Selma de Andrade. Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes. Mem Inst Oswaldo Cruz, v.107, n.3, p.317-325, May 2012.0074-0276https://www.arca.fiocruz.br/handle/icict/188171678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzVírus da Hepatite BTerapiaLamivudinaResistência a medicamentos antiviraisHBVTherapylamivudineantiviral drug resistanceAntiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecularl. Rio de Janeiro, RJ. Brasil.Laboratório Central de Saúde Pública Noel Nutels. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecularl. Rio de Janeiro, RJ. Brasil.The effectiveness of antiviral treatments of chronic hepatitis B has been poorly studied in Brazil. Here, hepatitis B virus (HBV) DNA positivity, drug resistance mutations and their association with HBV genotypes were evaluated in chronically HBV-infected patients under different drug regimens in Brazil. The study involved 129 patients under interferon or nucleos(t)ide analogue therapy for a median treatment time of 12 months. One hundred and five (81%) of these patients were treated with lamivudine (LAM), either in monotherapy or in combination with newer drugs, such as entecavir (ETV) or tenofovir (TDF). High (37.5-100%) rates of HBV DNA positivity were observed with all but one drug regimen (LAM + ETV). However, patients that were treated with ETV alone, TDF alone or with LAM combination therapies had a mean viral load that was 3-4 log lower than patients treated with LAM monotherapy. Of the patients treated with LAM, 47% developed resistance mutations. HBV genotypes A (59.1%), D (30.3%) and F (9.1%) were found. There was no association between the presence of LAM resistance mutations and genotypes, HBeAg status or treatment duration. Nevertheless, the rtM204V mutation was observed more frequently (12/13, 92%) in genotype A than in the others (p = 0.023). Six out of nine isolates that contained the rtM204I mutation belonged to genotype D and half of them displayed a single mutation. Genotype D isolates with the rtM204V variant preferentially displayed a triple mutation, while genotype A preferentially displayed a double mutation (p = 0.04).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18817/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfrancisco2_mello_etal_IOC_2012.pdffrancisco2_mello_etal_IOC_2012.pdfapplication/pdf492254https://www.arca.fiocruz.br/bitstream/icict/18817/2/francisco2_mello_etal_IOC_2012.pdf971fc24374b73c393618474f1b283a02MD52TEXTfrancisco2_mello_etal_IOC_2012.pdf.txtfrancisco2_mello_etal_IOC_2012.pdf.txtExtracted texttext/plain47008https://www.arca.fiocruz.br/bitstream/icict/18817/3/francisco2_mello_etal_IOC_2012.pdf.txtbd577996b7d652bba8e6a7a79a6d4f87MD53icict/188172018-08-15 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dc.title.pt_BR.fl_str_mv Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
title Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
spellingShingle Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
Mello, Francisco Campello do Amaral
Vírus da Hepatite B
Terapia
Lamivudina
Resistência a medicamentos antivirais
HBV
Therapy
lamivudine
antiviral drug resistance
title_short Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
title_full Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
title_fullStr Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
title_full_unstemmed Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
title_sort Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
author Mello, Francisco Campello do Amaral
author_facet Mello, Francisco Campello do Amaral
Fernandes, Carlos Augusto
Gomes, Selma de Andrade
author_role author
author2 Fernandes, Carlos Augusto
Gomes, Selma de Andrade
author2_role author
author
dc.contributor.author.fl_str_mv Mello, Francisco Campello do Amaral
Fernandes, Carlos Augusto
Gomes, Selma de Andrade
dc.subject.other.pt_BR.fl_str_mv Vírus da Hepatite B
Terapia
Lamivudina
Resistência a medicamentos antivirais
topic Vírus da Hepatite B
Terapia
Lamivudina
Resistência a medicamentos antivirais
HBV
Therapy
lamivudine
antiviral drug resistance
dc.subject.en.pt_BR.fl_str_mv HBV
Therapy
lamivudine
antiviral drug resistance
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecularl. Rio de Janeiro, RJ. Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-05-11T14:08:54Z
dc.date.available.fl_str_mv 2017-05-11T14:08:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELLO, Francisco Campello do Amaral; FERNANDES, Carlos Augusto; GOMES, Selma de Andrade. Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes. Mem Inst Oswaldo Cruz, v.107, n.3, p.317-325, May 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18817
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MELLO, Francisco Campello do Amaral; FERNANDES, Carlos Augusto; GOMES, Selma de Andrade. Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes. Mem Inst Oswaldo Cruz, v.107, n.3, p.317-325, May 2012.
0074-0276
1678-8060
url https://www.arca.fiocruz.br/handle/icict/18817
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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