Thymus involution in alloxan diabetes: analysis of mast cells

Detalhes bibliográficos
Autor(a) principal: Barreto, E. O.
Data de Publicação: 2005
Outros Autores: Riederer, I., Arantes, A. C. S., Carvalho, V. F., Farias Filho, F. A., Cordeiro, R. S. B., Martins, M. A., Savino, Wilson, Silva, P. M. R. e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37570
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
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spelling Barreto, E. O.Riederer, I.Arantes, A. C. S.Carvalho, V. F.Farias Filho, F. A.Cordeiro, R. S. B.Martins, M. A.Savino, WilsonSilva, P. M. R. e2019-12-04T13:55:25Z2019-12-04T13:55:25Z2005BARRETO, E. O. et al. Thymus involution in alloxan diabetes: analysis of mast cells. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Supl. 1, p. 127-130, 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/3757010.1590/s0074-027620050009000221678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.DiabetesMastócitosTimoMatriz extracelularDiabetesMast cellsThymusExtracellular matrixThymus involution in alloxan diabetes: analysis of mast cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37570/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_VFCarvalho_etal_IOC_2005.pdfWilsonSavino_VFCarvalho_etal_IOC_2005.pdfapplication/pdf82755https://www.arca.fiocruz.br/bitstream/icict/37570/2/WilsonSavino_VFCarvalho_etal_IOC_2005.pdf4c674830c66d9bd1570abf31502b69bcMD52TEXTWilsonSavino_VFCarvalho_etal_IOC_2005.pdf.txtWilsonSavino_VFCarvalho_etal_IOC_2005.pdf.txtExtracted texttext/plain15428https://www.arca.fiocruz.br/bitstream/icict/37570/3/WilsonSavino_VFCarvalho_etal_IOC_2005.pdf.txt0a673c852748d0c0f555334d917f0fefMD53icict/375702019-12-06 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dc.title.pt_BR.fl_str_mv Thymus involution in alloxan diabetes: analysis of mast cells
title Thymus involution in alloxan diabetes: analysis of mast cells
spellingShingle Thymus involution in alloxan diabetes: analysis of mast cells
Barreto, E. O.
Diabetes
Mastócitos
Timo
Matriz extracelular
Diabetes
Mast cells
Thymus
Extracellular matrix
title_short Thymus involution in alloxan diabetes: analysis of mast cells
title_full Thymus involution in alloxan diabetes: analysis of mast cells
title_fullStr Thymus involution in alloxan diabetes: analysis of mast cells
title_full_unstemmed Thymus involution in alloxan diabetes: analysis of mast cells
title_sort Thymus involution in alloxan diabetes: analysis of mast cells
author Barreto, E. O.
author_facet Barreto, E. O.
Riederer, I.
Arantes, A. C. S.
Carvalho, V. F.
Farias Filho, F. A.
Cordeiro, R. S. B.
Martins, M. A.
Savino, Wilson
Silva, P. M. R. e
author_role author
author2 Riederer, I.
Arantes, A. C. S.
Carvalho, V. F.
Farias Filho, F. A.
Cordeiro, R. S. B.
Martins, M. A.
Savino, Wilson
Silva, P. M. R. e
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barreto, E. O.
Riederer, I.
Arantes, A. C. S.
Carvalho, V. F.
Farias Filho, F. A.
Cordeiro, R. S. B.
Martins, M. A.
Savino, Wilson
Silva, P. M. R. e
dc.subject.other.pt_BR.fl_str_mv Diabetes
Mastócitos
Timo
Matriz extracelular
topic Diabetes
Mastócitos
Timo
Matriz extracelular
Diabetes
Mast cells
Thymus
Extracellular matrix
dc.subject.en.pt_BR.fl_str_mv Diabetes
Mast cells
Thymus
Extracellular matrix
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-12-04T13:55:25Z
dc.date.available.fl_str_mv 2019-12-04T13:55:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARRETO, E. O. et al. Thymus involution in alloxan diabetes: analysis of mast cells. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Supl. 1, p. 127-130, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37570
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762005000900022
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv BARRETO, E. O. et al. Thymus involution in alloxan diabetes: analysis of mast cells. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Supl. 1, p. 127-130, 2005.
0074-0276
10.1590/s0074-02762005000900022
1678-8060
url https://www.arca.fiocruz.br/handle/icict/37570
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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