Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27200 |
Resumo: | London School of Hygiene and Tropical Medicin. London, United Kingdom / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil. |
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Paixão, Enny S.Ferreira, Andrêa J. F.Santos, Idália Oliveira dosRodrigues, Laura C.Fiaccone, RosemeireSalvi, LeonardoOliveira, Guilherme Lopes deSantana, José GuilhermeCardoso, Andrey MoreiraTeles, Carlos Antônio de S. S.Soares, Maria AuxiliadoraAmaral, ElianaSmeeth, LiamBarreto, Mauricio L.Ichihara, Maria Yury2018-06-29T16:05:23Z2018-06-29T16:05:23Z2023PAIXÃO, Enny S. et al. Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study. PLOS Medicine, v. 20, n. 4, p. 1-16, Apr. 7, 2023.1549-1277https://www.arca.fiocruz.br/handle/icict/2720010.1371/journal.pmed.1004209engPublic Library of ScienceMortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLondon School of Hygiene and Tropical Medicin. London, United Kingdom / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicin. London, United Kingdom / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Matemática e Estatística. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Centro Federal de Educação Tecnológica de Minas Gerais. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Matemática e Estatística. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.University of Campinas. School of Medical Sciences. Campinas, SP, Brasil.London School of Hygiene and Tropical Medicin. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.Background: Congenital syphilis (CS) is a major and avoidable cause of neonatal death worldwide. In this study, we aimed to estimate excess all-cause mortality in children under 5 years with CS compared to those without CS. Methods and findings: In this population-based cohort study, we used linked, routinely collected data from Brazil from January 2011 to December 2017. Cox survival models were adjusted for maternal region of residence, maternal age, education, material status, self-declared race and newborn sex, and year of birth and stratified according to maternal treatment status, non-treponemal titers and presence of signs and symptoms at birth. Over 7 years, a total of 20 057 013 live-born children followed up (through linkage) to 5 years of age, 93 525 were registered with CS, and 2 476 died. The all-cause mortality rate in the CS group was 7·84/1 000 person-years compared with 2·92/1 000 person-years in children without CS, crude hazard ratio (HR) = 2·41 (95% CI 2·31 to 2·50). In the fully adjusted model, the highest under-five mortality risk was observed among children with CS from untreated mothers HR = 2·82 (95% CI 2·63 to 3·02), infants with non-treponemal titer higher than 1:64 HR = 8·87 (95% CI 7·70 to 10·22), and children with signs and symptoms at birth HR = 7·10 (95% CI 6·60 to 7·63). Among children registered with CS, CS was recorded as the underlying cause of death in 33% (495/1 496) of neonatal, 11% (85/770) of postneonatal, and 2·9% (6/210) of children 1 year of age. The main limitations of this study were the use of a secondary database without additional clinical information and the potential misclassification of exposure status. Conclusions: This study showed an increased mortality risk among children with CS that goes beyond the first year of life. It also reinforces the importance of maternal treatment that infant non-treponemal titers and the presence of signs and symptoms of CS at birth are strongly associated with subsequent mortality.Congenital syphilisChildrenMortalityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPaixao_Enny_etal_IGM_ENSP_2023.pdfPaixao_Enny_etal_IGM_ENSP_2023.pdfapplication/pdf737377https://www.arca.fiocruz.br/bitstream/icict/27200/2/Paixao_Enny_etal_IGM_ENSP_2023.pdf90d3a84a88ddf6e8e223c1afc3fc720fMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-83134https://www.arca.fiocruz.br/bitstream/icict/27200/1/license.txt4f0b8b537342850040456617144dec21MD51icict/272002023-04-28 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| dc.title.pt_BR.fl_str_mv |
Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study |
| title |
Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study |
| spellingShingle |
Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study Paixão, Enny S. Congenital syphilis Children Mortality |
| title_short |
Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study |
| title_full |
Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study |
| title_fullStr |
Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study |
| title_full_unstemmed |
Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study |
| title_sort |
Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study |
| author |
Paixão, Enny S. |
| author_facet |
Paixão, Enny S. Ferreira, Andrêa J. F. Santos, Idália Oliveira dos Rodrigues, Laura C. Fiaccone, Rosemeire Salvi, Leonardo Oliveira, Guilherme Lopes de Santana, José Guilherme Cardoso, Andrey Moreira Teles, Carlos Antônio de S. S. Soares, Maria Auxiliadora Amaral, Eliana Smeeth, Liam Barreto, Mauricio L. Ichihara, Maria Yury |
| author_role |
author |
| author2 |
Ferreira, Andrêa J. F. Santos, Idália Oliveira dos Rodrigues, Laura C. Fiaccone, Rosemeire Salvi, Leonardo Oliveira, Guilherme Lopes de Santana, José Guilherme Cardoso, Andrey Moreira Teles, Carlos Antônio de S. S. Soares, Maria Auxiliadora Amaral, Eliana Smeeth, Liam Barreto, Mauricio L. Ichihara, Maria Yury |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paixão, Enny S. Ferreira, Andrêa J. F. Santos, Idália Oliveira dos Rodrigues, Laura C. Fiaccone, Rosemeire Salvi, Leonardo Oliveira, Guilherme Lopes de Santana, José Guilherme Cardoso, Andrey Moreira Teles, Carlos Antônio de S. S. Soares, Maria Auxiliadora Amaral, Eliana Smeeth, Liam Barreto, Mauricio L. Ichihara, Maria Yury |
| dc.subject.en.pt_BR.fl_str_mv |
Congenital syphilis Children Mortality |
| topic |
Congenital syphilis Children Mortality |
| description |
London School of Hygiene and Tropical Medicin. London, United Kingdom / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil. |
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2018 |
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2018-06-29T16:05:23Z |
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2018-06-29T16:05:23Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PAIXÃO, Enny S. et al. Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study. PLOS Medicine, v. 20, n. 4, p. 1-16, Apr. 7, 2023. |
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https://www.arca.fiocruz.br/handle/icict/27200 |
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1549-1277 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pmed.1004209 |
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PAIXÃO, Enny S. et al. Mortality in children under 5 years of age with congenital syphilis in Brazil: a nationwide cohort study. PLOS Medicine, v. 20, n. 4, p. 1-16, Apr. 7, 2023. 1549-1277 10.1371/journal.pmed.1004209 |
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Public Library of Science |
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Public Library of Science |
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