Mortality from congenital zika syndrome: nationwide cohort study in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51518 |
Resumo: | Supported by the Secretary of Health Surveillance, Ministry of Health of Brazil, and by grants from the Wellcome Trust (213589/Z/18/Z, to Dr. Paixao), the Wellcome Trust with the U.K. Department for International Development (205377/Z/16/Z, to Dr. Barreto), the British Council Newton Fund (527418645, to Dr. Brickley), and the European Union Horizon 2020 Research and Innovation Program under the Zika Preparedness Latin American Network (ZikaPLAN; 734584, to Dr. Brickley). |
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Paixão, Enny S.Cardim, Luciana L.Costa, Maria C. N.Brickley, Elizabeth B.Carvalho-Sauer, Rita C. O. deCarmo, Eduardo H.Andrade, Roberto F. S.Rodrigues, Moreno S.Veiga, Rafael V.Costa, Larissa C.Moore, Cynthia A.França, Giovanny V. A.Smeeth, LiamRodrigues, Laura C.Barreto, Mauricio L.Teixeira, Maria G.2022-03-03T14:30:53Z2022-03-03T14:30:53Z2022PAIXÃO, Enny S. et al. Mortality from congenital zika syndrome: nationwide cohort study in Brazil. The New England Journal of Medicine, v. 386, n.8, p.757-767, 2022.https://www.arca.fiocruz.br/handle/icict/5151810.1056/NEJMoa21011951533-4406Supported by the Secretary of Health Surveillance, Ministry of Health of Brazil, and by grants from the Wellcome Trust (213589/Z/18/Z, to Dr. Paixao), the Wellcome Trust with the U.K. Department for International Development (205377/Z/16/Z, to Dr. Barreto), the British Council Newton Fund (527418645, to Dr. Brickley), and the European Union Horizon 2020 Research and Innovation Program under the Zika Preparedness Latin American Network (ZikaPLAN; 734584, to Dr. Brickley).London School of Hygiene and Tropical Medicine. London, UK / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. London, UK.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.National Center on Birth Defects and Developmental Disabilities. Centers for Disease Control and Prevention. Division of Birth Defects and Infant Disorders. Atlanta, GA, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil.London School of Hygiene and Tropical Medicine. London, UK.London School of Hygiene and Tropical Medicine. London, UK.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.BACKGROUND Prenatal exposure to Zika virus has potential teratogenic effects, with a wide spec- trum of clinical presentation referred to as congenital Zika syndrome. Data on survival among children with congenital Zika syndrome are limited. METHODS In this population-based cohort study, we used linked, routinely collected data in Brazil, from January 2015 through December 2018, to estimate mortality among live-born children with congenital Zika syndrome as compared with those without the syndrome. Kaplan–Meier curves and survival models were assessed with ad- justment for confounding and with stratification according to gestational age, birth weight, and status of being small for gestational age. RESULTS A total of 11,481,215 live-born children were followed to 36 months of age. The mortality rate was 52.6 deaths (95% confidence interval [CI], 47.6 to 58.0) per 1000 person-years among live-born children with congenital Zika syndrome, as com- pared with 5.6 deaths (95% CI, 5.6 to 5.7) per 1000 person-years among those without the syndrome. The mortality rate ratio among live-born children with congenital Zika syndrome, as compared with those without the syndrome, was 11.3 (95% CI, 10.2 to 12.4). Among infants born before 32 weeks of gestation or with a birth weight of less than 1500 g, the risks of death were similar regardless of congenital Zika syndrome status. Among infants born at term, those with con- genital Zika syndrome were 14.3 times (95% CI, 12.4 to 16.4) as likely to die as those without the syndrome (mortality rate, 38.4 vs. 2.7 deaths per 1000 person- years). Among infants with a birth weight of 2500 g or greater, those with con- genital Zika syndrome were 12.9 times (95% CI, 10.9 to 15.3) as likely to die as those without the syndrome (mortality rate, 32.6 vs. 2.5 deaths per 1000 person- years). The burden of congenital anomalies, diseases of the nervous system, and infectious diseases as recorded causes of deaths was higher among live-born children with congenital Zika syndrome than among those without the syndrome. CONCLUSIONS The risk of death was higher among live-born children with congenital Zika syn- drome than among those without the syndrome and persisted throughout the first 3 years of life. (Funded by the Ministry of Health of Brazil and others.)engMassachusetts Medical SocietyMortalityCongenital Zika SyndromeCohort StudyBrazilMortalityCongenital Zika SyndromeCohort StudyBrazilMortalidadeInfecção por Zika virusEstudos de CoortesBrasilMortality from congenital zika syndrome: nationwide cohort study in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83128https://www.arca.fiocruz.br/bitstream/icict/51518/1/license.txt0a01a23320286399b52cf17eb1aafb12MD51ORIGINALnejmoa2101195.pdfnejmoa2101195.pdfapplication/pdf1247939https://www.arca.fiocruz.br/bitstream/icict/51518/2/nejmoa2101195.pdf52ea2b39bf7663cd9745b23326ec6027MD52icict/515182023-03-15 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| dc.title.pt_BR.fl_str_mv |
Mortality from congenital zika syndrome: nationwide cohort study in Brazil |
| title |
Mortality from congenital zika syndrome: nationwide cohort study in Brazil |
| spellingShingle |
Mortality from congenital zika syndrome: nationwide cohort study in Brazil Paixão, Enny S. Mortality Congenital Zika Syndrome Cohort Study Brazil Mortality Congenital Zika Syndrome Cohort Study Brazil Mortalidade Infecção por Zika virus Estudos de Coortes Brasil |
| title_short |
Mortality from congenital zika syndrome: nationwide cohort study in Brazil |
| title_full |
Mortality from congenital zika syndrome: nationwide cohort study in Brazil |
| title_fullStr |
Mortality from congenital zika syndrome: nationwide cohort study in Brazil |
| title_full_unstemmed |
Mortality from congenital zika syndrome: nationwide cohort study in Brazil |
| title_sort |
Mortality from congenital zika syndrome: nationwide cohort study in Brazil |
| author |
Paixão, Enny S. |
| author_facet |
Paixão, Enny S. Cardim, Luciana L. Costa, Maria C. N. Brickley, Elizabeth B. Carvalho-Sauer, Rita C. O. de Carmo, Eduardo H. Andrade, Roberto F. S. Rodrigues, Moreno S. Veiga, Rafael V. Costa, Larissa C. Moore, Cynthia A. França, Giovanny V. A. Smeeth, Liam Rodrigues, Laura C. Barreto, Mauricio L. Teixeira, Maria G. |
| author_role |
author |
| author2 |
Cardim, Luciana L. Costa, Maria C. N. Brickley, Elizabeth B. Carvalho-Sauer, Rita C. O. de Carmo, Eduardo H. Andrade, Roberto F. S. Rodrigues, Moreno S. Veiga, Rafael V. Costa, Larissa C. Moore, Cynthia A. França, Giovanny V. A. Smeeth, Liam Rodrigues, Laura C. Barreto, Mauricio L. Teixeira, Maria G. |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paixão, Enny S. Cardim, Luciana L. Costa, Maria C. N. Brickley, Elizabeth B. Carvalho-Sauer, Rita C. O. de Carmo, Eduardo H. Andrade, Roberto F. S. Rodrigues, Moreno S. Veiga, Rafael V. Costa, Larissa C. Moore, Cynthia A. França, Giovanny V. A. Smeeth, Liam Rodrigues, Laura C. Barreto, Mauricio L. Teixeira, Maria G. |
| dc.subject.mesh.pt_BR.fl_str_mv |
Mortality Congenital Zika Syndrome Cohort Study Brazil |
| topic |
Mortality Congenital Zika Syndrome Cohort Study Brazil Mortality Congenital Zika Syndrome Cohort Study Brazil Mortalidade Infecção por Zika virus Estudos de Coortes Brasil |
| dc.subject.en.pt_BR.fl_str_mv |
Mortality Congenital Zika Syndrome Cohort Study Brazil |
| dc.subject.decs.pt_BR.fl_str_mv |
Mortalidade Infecção por Zika virus Estudos de Coortes Brasil |
| description |
Supported by the Secretary of Health Surveillance, Ministry of Health of Brazil, and by grants from the Wellcome Trust (213589/Z/18/Z, to Dr. Paixao), the Wellcome Trust with the U.K. Department for International Development (205377/Z/16/Z, to Dr. Barreto), the British Council Newton Fund (527418645, to Dr. Brickley), and the European Union Horizon 2020 Research and Innovation Program under the Zika Preparedness Latin American Network (ZikaPLAN; 734584, to Dr. Brickley). |
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2022 |
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2022-03-03T14:30:53Z |
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2022-03-03T14:30:53Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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PAIXÃO, Enny S. et al. Mortality from congenital zika syndrome: nationwide cohort study in Brazil. The New England Journal of Medicine, v. 386, n.8, p.757-767, 2022. |
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https://www.arca.fiocruz.br/handle/icict/51518 |
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10.1056/NEJMoa2101195 |
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1533-4406 |
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PAIXÃO, Enny S. et al. Mortality from congenital zika syndrome: nationwide cohort study in Brazil. The New England Journal of Medicine, v. 386, n.8, p.757-767, 2022. 10.1056/NEJMoa2101195 1533-4406 |
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Massachusetts Medical Society |
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Massachusetts Medical Society |
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