Schistosoma tegument proteins in vaccine and diagnosis development: an update

Detalhes bibliográficos
Autor(a) principal: Fonseca, Cristina Toscano
Data de Publicação: 2012
Outros Autores: Carvalho, Gardênia Braz Figueiredo de, Alves, Clarice Carvalho, Melo, Tatiane Teixeira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7451
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciências e Tecnologia em Doenças. Belo Horizonte, MG, Brazil
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spelling Fonseca, Cristina ToscanoCarvalho, Gardênia Braz Figueiredo deAlves, Clarice CarvalhoMelo, Tatiane Teixeira de2014-03-26T16:20:22Z2014-03-26T16:20:22Z2012FONSECA, Cristina Toscano et al. Schistosoma tegument proteins in vaccine and diagnosis development: an update. Journal of Parasitology Research. 2012, vol.2012, pp. 1-8https://www.arca.fiocruz.br/handle/icict/745110.1155/2012/541268engHindawi Publishing CorporationSchistosoma tegument proteins in vaccine and diagnosis development: an updateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciências e Tecnologia em Doenças. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrazilThe development of a vaccine against schistosomiasis and also the availability of a more sensitive diagnosis test are important tools to help chemotherapy in controlling disease transmission. Bioinformatics tools, together with the access to parasite genome, published recently, should help generate new knowledge on parasite biology and search for new vaccines or therapeutic targets and antigens to be used in the disease diagnosis. Parasite surface proteins, especially those expressed in schistosomula tegument, represent interesting targets to be used in vaccine formulations and in the diagnosis of early infections, since the tegument represents the interface between host and parasite and its molecules are responsible for essential functions to parasite survival. In this paper we will present the advances in the development of vaccines and diagnosis tests achieved with the use of the information from schistosome genome focused on parasite tegument as a source for antigens.vaccineschistosomiasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSchistosoma Tegument Proteins in Vaccine and Diagnosis Development.pdfSchistosoma Tegument Proteins in Vaccine and Diagnosis Development.pdfapplication/pdf1210753https://www.arca.fiocruz.br/bitstream/icict/7451/1/Schistosoma%20Tegument%20Proteins%20in%20Vaccine%20and%20Diagnosis%20Development.pdf7f4fff99fce8ba0f236ad12ae5450256MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7451/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSchistosoma Tegument Proteins in Vaccine and Diagnosis Development.pdf.txtSchistosoma Tegument Proteins in Vaccine and Diagnosis Development.pdf.txtExtracted texttext/plain43540https://www.arca.fiocruz.br/bitstream/icict/7451/5/Schistosoma%20Tegument%20Proteins%20in%20Vaccine%20and%20Diagnosis%20Development.pdf.txt89dac0b4ceb04e2664504783c167c3fdMD55THUMBNAILSchistosoma Tegument Proteins in Vaccine and Diagnosis Development.pdf.jpgSchistosoma Tegument Proteins in Vaccine and Diagnosis Development.pdf.jpgGenerated Thumbnailimage/jpeg1778https://www.arca.fiocruz.br/bitstream/icict/7451/4/Schistosoma%20Tegument%20Proteins%20in%20Vaccine%20and%20Diagnosis%20Development.pdf.jpg6a13a2326c00f8571037359e77686391MD54icict/74512018-04-06 11:25:52.148oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T14:25:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Schistosoma tegument proteins in vaccine and diagnosis development: an update
title Schistosoma tegument proteins in vaccine and diagnosis development: an update
spellingShingle Schistosoma tegument proteins in vaccine and diagnosis development: an update
Fonseca, Cristina Toscano
vaccine
schistosomiasis
title_short Schistosoma tegument proteins in vaccine and diagnosis development: an update
title_full Schistosoma tegument proteins in vaccine and diagnosis development: an update
title_fullStr Schistosoma tegument proteins in vaccine and diagnosis development: an update
title_full_unstemmed Schistosoma tegument proteins in vaccine and diagnosis development: an update
title_sort Schistosoma tegument proteins in vaccine and diagnosis development: an update
author Fonseca, Cristina Toscano
author_facet Fonseca, Cristina Toscano
Carvalho, Gardênia Braz Figueiredo de
Alves, Clarice Carvalho
Melo, Tatiane Teixeira de
author_role author
author2 Carvalho, Gardênia Braz Figueiredo de
Alves, Clarice Carvalho
Melo, Tatiane Teixeira de
author2_role author
author
author
dc.contributor.author.fl_str_mv Fonseca, Cristina Toscano
Carvalho, Gardênia Braz Figueiredo de
Alves, Clarice Carvalho
Melo, Tatiane Teixeira de
dc.subject.en.pt_BR.fl_str_mv vaccine
schistosomiasis
topic vaccine
schistosomiasis
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciências e Tecnologia em Doenças. Belo Horizonte, MG, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-03-26T16:20:22Z
dc.date.available.fl_str_mv 2014-03-26T16:20:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Cristina Toscano et al. Schistosoma tegument proteins in vaccine and diagnosis development: an update. Journal of Parasitology Research. 2012, vol.2012, pp. 1-8
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7451
dc.identifier.doi.none.fl_str_mv 10.1155/2012/541268
identifier_str_mv FONSECA, Cristina Toscano et al. Schistosoma tegument proteins in vaccine and diagnosis development: an update. Journal of Parasitology Research. 2012, vol.2012, pp. 1-8
10.1155/2012/541268
url https://www.arca.fiocruz.br/handle/icict/7451
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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