Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57005 |
Resumo: | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil. |
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Severo, VanessaSouza, RodolphoVitorino, FranciscaCunha, JuliaÁvila, AndréaArrizabalaga, GustavoNardelli, Sheila2023-02-10T16:06:24Z2023-02-10T16:06:24Z2023SEVERO, Vanessa et al. Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii. mSphere., v. 7 n. 6, p. 1–19, 2022.2379-5042https://www.arca.fiocruz.br/handle/icict/5700510.1128/msphere.00403-22porAmerican Society for MicrobiologyToxoplasma gondiiModificação Pós-TraducionalChromatinHistone H1Cell DivisionProtein Processing, Post-TranslationalCromatinaDivisión CelularProcesamiento Proteico-PostraduccionalChromatineHistoneDivision cellulaireMaturation post-traductionnelle des protéinesCromatinaHistonasDivisão CelularProcessamento de Proteína Pós-TraducionalPreviously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondiiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil.Department of Pharmacology and Toxicology. Indiana University School of Medicine. Indianapolis, Indiana, USA.Instituto Butantan. Laboratório de Ciclo Celular. São Paulo, SP, Brasil.Instituto Butantan. Laboratório de Ciclo Celular. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil.Department of Pharmacology and Toxicology. Indiana University School of Medicine. Indianapolis, Indiana, USA.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil.Chromatin dynamics can regulate all DNA-dependent processes. Access to DNA within chromatin is orchestrated mainly by histones and their posttranslational modifications (PTMs). Like other eukaryotes, the apicomplexan parasite Toxoplasma gondii encodes four canonical histones and five histone variants. In contrast, the linker histone (H1) has never been identified in apicomplexan parasites. In other eukaryotes, histone H1 compacts the chromatin by linking the nucleosome and increasing the DNA compaction. H1 is a multifunctional protein and can be involved in different steps of DNA metabolism or associated with protein complexes related to distinct biological processes. We have identified a novel protein in T. gondii (“TgH1-like”) that, although lacking the globular domain of mammalian H1, is remarkably like the H1-like proteins of bacteria and trypanosomatids. Our results demonstrate that TgH1-like is a nuclear protein associated with chromatin and other histones. Curiously, TgH1-like is also in the nucleolus and associated with ribosomal proteins, indicating a versatile function in this parasite. Although knockout of the tgh1-like gene does not affect the cell cycle, it causes endopolygeny and asynchronous division. Interestingly, mutation of posttranslationally modified amino acids results in defects in cell division like those in the Dtgh1-like mutant, showing that these sites are important for protein function. Furthermore, in the bradyzoite stage, this protein is expressed only in dividing parasites, reinforcing its importance in cell division. Indeed, the absence of TgH1-like decreases compaction of peripheral chromatin, confirming its role in the chromatin modulation in T. gondii.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57005/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmsphere.00403-22ok.pdfmsphere.00403-22ok.pdfapplication/pdf6223551https://www.arca.fiocruz.br/bitstream/icict/57005/2/msphere.00403-22ok.pdfb17681bdea48fa51b4f2ce7c1e48758bMD52icict/570052023-02-10 13:06:25.693oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-02-10T16:06:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.en_US.fl_str_mv |
Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii |
title |
Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii |
spellingShingle |
Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii Severo, Vanessa Toxoplasma gondii Modificação Pós-Traducional Chromatin Histone H1 Cell Division Protein Processing, Post-Translational Cromatina División Celular Procesamiento Proteico-Postraduccional Chromatine Histone Division cellulaire Maturation post-traductionnelle des protéines Cromatina Histonas Divisão Celular Processamento de Proteína Pós-Traducional |
title_short |
Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii |
title_full |
Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii |
title_fullStr |
Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii |
title_full_unstemmed |
Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii |
title_sort |
Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii |
author |
Severo, Vanessa |
author_facet |
Severo, Vanessa Souza, Rodolpho Vitorino, Francisca Cunha, Julia Ávila, Andréa Arrizabalaga, Gustavo Nardelli, Sheila |
author_role |
author |
author2 |
Souza, Rodolpho Vitorino, Francisca Cunha, Julia Ávila, Andréa Arrizabalaga, Gustavo Nardelli, Sheila |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Severo, Vanessa Souza, Rodolpho Vitorino, Francisca Cunha, Julia Ávila, Andréa Arrizabalaga, Gustavo Nardelli, Sheila |
dc.subject.other.en_US.fl_str_mv |
Toxoplasma gondii Modificação Pós-Traducional |
topic |
Toxoplasma gondii Modificação Pós-Traducional Chromatin Histone H1 Cell Division Protein Processing, Post-Translational Cromatina División Celular Procesamiento Proteico-Postraduccional Chromatine Histone Division cellulaire Maturation post-traductionnelle des protéines Cromatina Histonas Divisão Celular Processamento de Proteína Pós-Traducional |
dc.subject.en.en_US.fl_str_mv |
Chromatin Histone H1 Cell Division Protein Processing, Post-Translational |
dc.subject.es.en_US.fl_str_mv |
Cromatina División Celular Procesamiento Proteico-Postraduccional |
dc.subject.fr.en_US.fl_str_mv |
Chromatine Histone Division cellulaire Maturation post-traductionnelle des protéines |
dc.subject.decs.en_US.fl_str_mv |
Cromatina Histonas Divisão Celular Processamento de Proteína Pós-Traducional |
description |
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-02-10T16:06:24Z |
dc.date.available.fl_str_mv |
2023-02-10T16:06:24Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SEVERO, Vanessa et al. Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii. mSphere., v. 7 n. 6, p. 1–19, 2022. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57005 |
dc.identifier.issn.en_US.fl_str_mv |
2379-5042 |
dc.identifier.doi.none.fl_str_mv |
10.1128/msphere.00403-22 |
identifier_str_mv |
SEVERO, Vanessa et al. Previously unidentified histone H1-like protein is involved in cell division and ribosome biosynthesis in Toxoplasma gondii. mSphere., v. 7 n. 6, p. 1–19, 2022. 2379-5042 10.1128/msphere.00403-22 |
url |
https://www.arca.fiocruz.br/handle/icict/57005 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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American Society for Microbiology |
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American Society for Microbiology |
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