The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19)
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44410 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil. |
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Arcanjo, AngélicaLogullo, JorgeteMenezes, Camilla Cristie BarretoGiangiarulo, Thais Chrispim de Souza CarvalhoReis, Mirella Carneiro dosCastro, Gabriellen Menezes Migliani deFontes, Yasmin da SilvaTodeschini, Adriane ReginaLima, Leonardo Freire deRicardo, Debora DecotePereira, Antônio FerreiraLima, Celio Geraldo Freire deBarroso, Shana Priscila CoutinhoTakyia, ChristinaSilva, Fátima ConceiçãoSavino, WilsonMorrot, Alexandre2020-11-14T14:27:46Z2020-11-14T14:27:46Z2020ARCANJO, Angélica et al. The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19). Scientific Reports, v. 10, p. 1-11, 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/4441010.1038/s41598-020-76781-0engNature ResearchCOVID-19Coronavirus 2NeutrófilosPapel emergenteArmadilhas extracelularesCOVID-19Coronavirus 2Severe acute respiratory syndromeNeutrophilsExtracellular trapsThe emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Ri de Janeiro, RJ, Brasil.Hospital Naval Marcílio Dias. Insituto de Pesquisa Biomédica, Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcílio Dias. Divisão de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Hospital Naval Marcílio Dias. Insituto de Pesquisa Biomédica, Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Bld. Leônidas and Maria Deane/Room 406C. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede de Pesquisa em Neuroimunomodulação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Ri de Janeiro, RJ,Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Bld. Leônidas and Maria Deane/Room 406C. Rio de Janeiro, RJ, Brasil.The novel coronavirus SARS-CoV-2 causes COVID-19, a highly pathogenic viral infection threatening millions. The majority of the individuals infected are asymptomatic or mildly symptomatic showing typical clinical signs of common cold. However, approximately 20% of the patients can progress to acute respiratory distress syndrome (ARDS), evolving to death in about 5% of cases. Recently, angiotensin-converting enzyme 2 (ACE2) has been shown to be a functional receptor for virus entry into host target cells. The upregulation of ACE2 in patients with comorbidities may represent a propensity for increased viral load and spreading of infection to extrapulmonary tissues. This systemic infection is associated with higher neutrophil to lymphocyte ratio in infected tissues and high levels of pro-infammatory cytokines leading to an extensive microthrombus formation with multiorgan failure. Herein we investigated whether SARS-CoV-2 can stimulate extracellular neutrophils traps (NETs) in a process called NETosis. We demonstrated for the frst time that SARS-CoV-2 in fact is able to activate NETosis in human neutrophils. Our fndings indicated that this process is associated with increased levels of intracellular Reactive Oxygen Species (ROS) in neutrophils. The ROS-NET pathway plays a role in thrombosis formation and our study suggest the importance of this target for therapy approaches against disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44410/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_FatimaConceição_etal_IOC_2020.pdfWilsonSavino_FatimaConceição_etal_IOC_2020.pdfapplication/pdf1288489https://www.arca.fiocruz.br/bitstream/icict/44410/2/WilsonSavino_FatimaConcei%c3%a7%c3%a3o_etal_IOC_2020.pdf0a5cfc7e7224ff2873df566f7df50ee2MD52TEXTWilsonSavino_FatimaConceição_etal_IOC_2020.pdf.txtWilsonSavino_FatimaConceição_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19) |
title |
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19) |
spellingShingle |
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19) Arcanjo, Angélica COVID-19 Coronavirus 2 Neutrófilos Papel emergente Armadilhas extracelulares COVID-19 Coronavirus 2 Severe acute respiratory syndrome Neutrophils Extracellular traps |
title_short |
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19) |
title_full |
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19) |
title_fullStr |
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19) |
title_full_unstemmed |
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19) |
title_sort |
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19) |
author |
Arcanjo, Angélica |
author_facet |
Arcanjo, Angélica Logullo, Jorgete Menezes, Camilla Cristie Barreto Giangiarulo, Thais Chrispim de Souza Carvalho Reis, Mirella Carneiro dos Castro, Gabriellen Menezes Migliani de Fontes, Yasmin da Silva Todeschini, Adriane Regina Lima, Leonardo Freire de Ricardo, Debora Decote Pereira, Antônio Ferreira Lima, Celio Geraldo Freire de Barroso, Shana Priscila Coutinho Takyia, Christina Silva, Fátima Conceição Savino, Wilson Morrot, Alexandre |
author_role |
author |
author2 |
Logullo, Jorgete Menezes, Camilla Cristie Barreto Giangiarulo, Thais Chrispim de Souza Carvalho Reis, Mirella Carneiro dos Castro, Gabriellen Menezes Migliani de Fontes, Yasmin da Silva Todeschini, Adriane Regina Lima, Leonardo Freire de Ricardo, Debora Decote Pereira, Antônio Ferreira Lima, Celio Geraldo Freire de Barroso, Shana Priscila Coutinho Takyia, Christina Silva, Fátima Conceição Savino, Wilson Morrot, Alexandre |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Arcanjo, Angélica Logullo, Jorgete Menezes, Camilla Cristie Barreto Giangiarulo, Thais Chrispim de Souza Carvalho Reis, Mirella Carneiro dos Castro, Gabriellen Menezes Migliani de Fontes, Yasmin da Silva Todeschini, Adriane Regina Lima, Leonardo Freire de Ricardo, Debora Decote Pereira, Antônio Ferreira Lima, Celio Geraldo Freire de Barroso, Shana Priscila Coutinho Takyia, Christina Silva, Fátima Conceição Savino, Wilson Morrot, Alexandre |
dc.subject.other.pt_BR.fl_str_mv |
COVID-19 Coronavirus 2 Neutrófilos Papel emergente Armadilhas extracelulares |
topic |
COVID-19 Coronavirus 2 Neutrófilos Papel emergente Armadilhas extracelulares COVID-19 Coronavirus 2 Severe acute respiratory syndrome Neutrophils Extracellular traps |
dc.subject.en.pt_BR.fl_str_mv |
COVID-19 Coronavirus 2 Severe acute respiratory syndrome Neutrophils Extracellular traps |
description |
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-11-14T14:27:46Z |
dc.date.available.fl_str_mv |
2020-11-14T14:27:46Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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dc.identifier.citation.fl_str_mv |
ARCANJO, Angélica et al. The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19). Scientific Reports, v. 10, p. 1-11, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44410 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/s41598-020-76781-0 |
identifier_str_mv |
ARCANJO, Angélica et al. The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID‑19). Scientific Reports, v. 10, p. 1-11, 2020. 2045-2322 10.1038/s41598-020-76781-0 |
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https://www.arca.fiocruz.br/handle/icict/44410 |
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Nature Research |
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Nature Research |
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