The Role of Innate Immunity in COVID-19

Detalhes bibliográficos
Autor(a) principal: Silva de Sordi, Luiz Henrique
Data de Publicação: 2020
Outros Autores: Magalhães, Isabela Sales Oliveira, Casselhas, Daniela Abreu, Andrade, Mariléia Chaves
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Ciências em Saúde
Texto Completo: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/997
Resumo: The immune system plays an essential role in the COVID-19 pandemic, as it is involved in the pathogenesis and worsening of the disease. The purpose of this review is to address aspects of innate immunity in COVID-19, especially the role of neutrophils. The innate immune system corresponds to the organism's first defense, but a balance must be effective against the invader without harming the host excessively. An immune imbalance is related to more severe conditions and aberrant neutrophil activation, with lymphopenia and neutrophilia being predictors of a worse prognosis in patients with COVID-19. Neutrophilia is speculated to be an important source for the excessive formation of NET (Neutrophil Extracellular Traps), leading to increased inflammatory response and unfavorable evolution of the disease. NETs are also associated with the cytokine storm, another mechanism related to COVID-19's gravity. Therefore, strategies involving immunomodulation may have an essential role in controlling the disease.
id RCS_9cde4f6f99d8434f6abbb8ca8e6f1d4a
oai_identifier_str oai:ojs.portalrcs.hcitajuba.org.br:article/997
network_acronym_str RCS
network_name_str Revista Ciências em Saúde
repository_id_str
spelling The Role of Innate Immunity in COVID-19 O Papel da Imunidade Inata na COVID-19 COVID-19Innate ImmunityNeutrophilsNeutrophil extracellular trapsCoronavirus InfectionsImunidade InataNeutrófilosArmadilhas ExtracelularesInfecções por coronavírusThe immune system plays an essential role in the COVID-19 pandemic, as it is involved in the pathogenesis and worsening of the disease. The purpose of this review is to address aspects of innate immunity in COVID-19, especially the role of neutrophils. The innate immune system corresponds to the organism's first defense, but a balance must be effective against the invader without harming the host excessively. An immune imbalance is related to more severe conditions and aberrant neutrophil activation, with lymphopenia and neutrophilia being predictors of a worse prognosis in patients with COVID-19. Neutrophilia is speculated to be an important source for the excessive formation of NET (Neutrophil Extracellular Traps), leading to increased inflammatory response and unfavorable evolution of the disease. NETs are also associated with the cytokine storm, another mechanism related to COVID-19's gravity. Therefore, strategies involving immunomodulation may have an essential role in controlling the disease.O sistema imune apresenta papel importante na pandemia da COVID-19, pois está envolvido na patogênese e agravamento da doença. O objetivo desta revisão é abordar os aspectos da imunidade inata na COVID-19, especialmente o papel dos neutrófilos. O sistema imune inato corresponde à primeira defesa do organismo, porém é necessário um equilíbrio para obter efetividade contra o invasor sem lesar excessivamente o hospedeiro. O desequilíbrio imune está relacionado com quadros mais graves e à ativação aberrante de neutrófilos, sendo a linfopenia e a neutrofilia preditores de pior prognóstico em pacientes com COVID-19.  Especula-se que a neutrofilia seja uma importante fonte para formação excessiva de NET (Neutrophil Extracellular Traps), levando ao aumento da resposta inflamatória e evolução desfavorável da doença. As NET também estão associadas à tempestade de citocinas, outro mecanismo relacionado a gravidade da COVID-19. Portanto, estratégias que envolvam a imunomodulação podem ter um papel importante no controle da doença.AISI/HCI2020-07-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos parestextoinfo:eu-repo/semantics/otherapplication/pdftext/xmlhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/99710.21876/rcshci.v10i3.997Revista Ciências em Saúde; v. 10 n. 3 (2020): Julho a Setembro de 2020; 5-8Health Sciences Journal; Vol 10 No 3 (2020): July to September 2020; 5-82236-378510.21876/rcshci.v10i3reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/997/551https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/997/575Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDEhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessSilva de Sordi, Luiz Henrique Magalhães, Isabela Sales OliveiraCasselhas, Daniela AbreuAndrade, Mariléia Chaves2021-03-27T15:32:41Zoai:ojs.portalrcs.hcitajuba.org.br:article/997Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2021-03-27T15:32:41Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse
dc.title.none.fl_str_mv The Role of Innate Immunity in COVID-19
O Papel da Imunidade Inata na COVID-19
title The Role of Innate Immunity in COVID-19
spellingShingle The Role of Innate Immunity in COVID-19
Silva de Sordi, Luiz Henrique
COVID-19
Innate Immunity
Neutrophils
Neutrophil extracellular traps
Coronavirus Infections
Imunidade Inata
Neutrófilos
Armadilhas Extracelulares
Infecções por coronavírus
title_short The Role of Innate Immunity in COVID-19
title_full The Role of Innate Immunity in COVID-19
title_fullStr The Role of Innate Immunity in COVID-19
title_full_unstemmed The Role of Innate Immunity in COVID-19
title_sort The Role of Innate Immunity in COVID-19
author Silva de Sordi, Luiz Henrique
author_facet Silva de Sordi, Luiz Henrique
Magalhães, Isabela Sales Oliveira
Casselhas, Daniela Abreu
Andrade, Mariléia Chaves
author_role author
author2 Magalhães, Isabela Sales Oliveira
Casselhas, Daniela Abreu
Andrade, Mariléia Chaves
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva de Sordi, Luiz Henrique
Magalhães, Isabela Sales Oliveira
Casselhas, Daniela Abreu
Andrade, Mariléia Chaves
dc.subject.por.fl_str_mv COVID-19
Innate Immunity
Neutrophils
Neutrophil extracellular traps
Coronavirus Infections
Imunidade Inata
Neutrófilos
Armadilhas Extracelulares
Infecções por coronavírus
topic COVID-19
Innate Immunity
Neutrophils
Neutrophil extracellular traps
Coronavirus Infections
Imunidade Inata
Neutrófilos
Armadilhas Extracelulares
Infecções por coronavírus
description The immune system plays an essential role in the COVID-19 pandemic, as it is involved in the pathogenesis and worsening of the disease. The purpose of this review is to address aspects of innate immunity in COVID-19, especially the role of neutrophils. The innate immune system corresponds to the organism's first defense, but a balance must be effective against the invader without harming the host excessively. An immune imbalance is related to more severe conditions and aberrant neutrophil activation, with lymphopenia and neutrophilia being predictors of a worse prognosis in patients with COVID-19. Neutrophilia is speculated to be an important source for the excessive formation of NET (Neutrophil Extracellular Traps), leading to increased inflammatory response and unfavorable evolution of the disease. NETs are also associated with the cytokine storm, another mechanism related to COVID-19's gravity. Therefore, strategies involving immunomodulation may have an essential role in controlling the disease.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-02
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer reviewed
Avaliado pelos pares
texto
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/997
10.21876/rcshci.v10i3.997
url https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/997
identifier_str_mv 10.21876/rcshci.v10i3.997
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/997/551
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/997/575
dc.rights.driver.fl_str_mv Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDE
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 REVISTA CIÊNCIAS EM SAÚDE
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/xml
dc.publisher.none.fl_str_mv AISI/HCI
publisher.none.fl_str_mv AISI/HCI
dc.source.none.fl_str_mv Revista Ciências em Saúde; v. 10 n. 3 (2020): Julho a Setembro de 2020; 5-8
Health Sciences Journal; Vol 10 No 3 (2020): July to September 2020; 5-8
2236-3785
10.21876/rcshci.v10i3
reponame:Revista Ciências em Saúde
instname:Hospital de Clínicas de Itajubá
instacron:HCI
instname_str Hospital de Clínicas de Itajubá
instacron_str HCI
institution HCI
reponame_str Revista Ciências em Saúde
collection Revista Ciências em Saúde
repository.name.fl_str_mv Revista Ciências em Saúde - Hospital de Clínicas de Itajubá
repository.mail.fl_str_mv rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br
_version_ 1797068962796666880

Registros relacionados