Cytotoxic activity in cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Campos, Taís Menezes Cerqueira
Data de Publicação: 2017
Outros Autores: Costa, Rúbia, Passos, Sara, Carvalho, Lucas Pedreira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24951
Resumo: National Institutes of Health (grant U01 AI088650-06).
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spelling Campos, Taís Menezes CerqueiraCosta, RúbiaPassos, SaraCarvalho, Lucas Pedreira de2018-02-26T19:34:38Z2018-02-26T19:34:38Z2017CAMPOS, T. M. C. et al. Cytotoxic activity in cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 112, n. 11, p. 733-740, 2017.0074-0276https://www.arca.fiocruz.br/handle/icict/2495110.1590/0074-02760170109National Institutes of Health (grant U01 AI088650-06).Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Houston Methodist Research Institute. Department of Nanomedicine. Houston, TX, USAUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia-Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilCutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.engInstituto Oswaldo CruzCitotoxicidadeCélulas T CD8 +Células NKLeishmaniose cutâneaImunopatologiaCytotoxicityCD8+ T cellsNK cellsCutaneous leishmaniasisImmunopathologyCytotoxic activity in cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24951/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCampos TM Cytotoxic activity in cutaneous leishmania....pdfCampos TM Cytotoxic activity in cutaneous 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dc.title.pt_BR.fl_str_mv Cytotoxic activity in cutaneous leishmaniasis
title Cytotoxic activity in cutaneous leishmaniasis
spellingShingle Cytotoxic activity in cutaneous leishmaniasis
Campos, Taís Menezes Cerqueira
Citotoxicidade
Células T CD8 +
Células NK
Leishmaniose cutânea
Imunopatologia
Cytotoxicity
CD8+ T cells
NK cells
Cutaneous leishmaniasis
Immunopathology
title_short Cytotoxic activity in cutaneous leishmaniasis
title_full Cytotoxic activity in cutaneous leishmaniasis
title_fullStr Cytotoxic activity in cutaneous leishmaniasis
title_full_unstemmed Cytotoxic activity in cutaneous leishmaniasis
title_sort Cytotoxic activity in cutaneous leishmaniasis
author Campos, Taís Menezes Cerqueira
author_facet Campos, Taís Menezes Cerqueira
Costa, Rúbia
Passos, Sara
Carvalho, Lucas Pedreira de
author_role author
author2 Costa, Rúbia
Passos, Sara
Carvalho, Lucas Pedreira de
author2_role author
author
author
dc.contributor.author.fl_str_mv Campos, Taís Menezes Cerqueira
Costa, Rúbia
Passos, Sara
Carvalho, Lucas Pedreira de
dc.subject.other.pt_BR.fl_str_mv Citotoxicidade
Células T CD8 +
Células NK
Leishmaniose cutânea
Imunopatologia
topic Citotoxicidade
Células T CD8 +
Células NK
Leishmaniose cutânea
Imunopatologia
Cytotoxicity
CD8+ T cells
NK cells
Cutaneous leishmaniasis
Immunopathology
dc.subject.en.pt_BR.fl_str_mv Cytotoxicity
CD8+ T cells
NK cells
Cutaneous leishmaniasis
Immunopathology
description National Institutes of Health (grant U01 AI088650-06).
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-26T19:34:38Z
dc.date.available.fl_str_mv 2018-02-26T19:34:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAMPOS, T. M. C. et al. Cytotoxic activity in cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 112, n. 11, p. 733-740, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24951
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760170109
identifier_str_mv CAMPOS, T. M. C. et al. Cytotoxic activity in cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 112, n. 11, p. 733-740, 2017.
0074-0276
10.1590/0074-02760170109
url https://www.arca.fiocruz.br/handle/icict/24951
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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