Cytotoxic activity in cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Campos,Taís M
Data de Publicação: 2017
Outros Autores: Costa,Rúbia, Passos,Sara, Carvalho,Lucas P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100733
Resumo: Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
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spelling Cytotoxic activity in cutaneous leishmaniasiscytotoxicityCD8+ T cellsNK cellscutaneous leishmaniasisimmunopathologyCutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.Instituto Oswaldo Cruz, Ministério da Saúde2017-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100733Memórias do Instituto Oswaldo Cruz v.112 n.11 2017reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-02760170109info:eu-repo/semantics/openAccessCampos,Taís MCosta,RúbiaPassos,SaraCarvalho,Lucas Peng2020-04-25T17:52:39Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:21:52.566Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Cytotoxic activity in cutaneous leishmaniasis
title Cytotoxic activity in cutaneous leishmaniasis
spellingShingle Cytotoxic activity in cutaneous leishmaniasis
Campos,Taís M
cytotoxicity
CD8+ T cells
NK cells
cutaneous leishmaniasis
immunopathology
title_short Cytotoxic activity in cutaneous leishmaniasis
title_full Cytotoxic activity in cutaneous leishmaniasis
title_fullStr Cytotoxic activity in cutaneous leishmaniasis
title_full_unstemmed Cytotoxic activity in cutaneous leishmaniasis
title_sort Cytotoxic activity in cutaneous leishmaniasis
author Campos,Taís M
author_facet Campos,Taís M
Costa,Rúbia
Passos,Sara
Carvalho,Lucas P
author_role author
author2 Costa,Rúbia
Passos,Sara
Carvalho,Lucas P
author2_role author
author
author
dc.contributor.author.fl_str_mv Campos,Taís M
Costa,Rúbia
Passos,Sara
Carvalho,Lucas P
dc.subject.por.fl_str_mv cytotoxicity
CD8+ T cells
NK cells
cutaneous leishmaniasis
immunopathology
topic cytotoxicity
CD8+ T cells
NK cells
cutaneous leishmaniasis
immunopathology
dc.description.none.fl_txt_mv Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
description Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100733
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100733
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-02760170109
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.112 n.11 2017
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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