Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses

Detalhes bibliográficos
Autor(a) principal: Gomes, Ana Thereza
Data de Publicação: 2006
Outros Autores: Cunha, Liliane Monteiro, Bastos, Carla Guimarães, Medrado, Bruno Frederico, Assis, Bárbara Cristina Alves de, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5948
Resumo: Universidade Federal da Bahia. Faculdade de Medicina. Salvador, Bahia, Brasil
id CRUZ_adad30043a664278adc11fb87cec9cec
oai_identifier_str oai:www.arca.fiocruz.br:icict/5948
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Gomes, Ana TherezaCunha, Liliane MonteiroBastos, Carla GuimarãesMedrado, Bruno FredericoAssis, Bárbara Cristina Alves deAndrade, Zilton de Araújo2012-12-10T17:51:06Z2012-12-10T17:51:06Z2006GOMES, A. T. et al. Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses. Memórias do Instituto Oswaldo Cruz, v. 101, n. 8, p. 895-898, dec. 2006.0074-0276https://www.arca.fiocruz.br/handle/icict/5948engCapillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent coursesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, Bahia, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, Bahia, BrasilEscola Bahiana de Medicina. Salvador, Bahia, BrasilEscola Bahiana de Medicina. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, BrasilCapillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.Capillaria hepaticaSeptal fibrosisRatsCorticosteroidsAntigenic stimulationCirrose Hepática Experimental/parasitologiaInfecções por Enoplida/parasitologiaCapillaria/imunologiaAnticorpos Anti-Helmínticos/sangueAntígenos de Helmintos/administração & dosagemCirrose Hepática Experimental/quimioterapiaCirrose Hepática Experimental/imunologiaInfecções por Enoplida/quimioterapiaInfecções por Enoplida/imunologiaÍndice de Gravidade de DoençaModelos Animais de DoençasHidroxiprolina/análiseGlucocorticóides/uso terapêuticoPrednisona/uso terapêuticoDoença CrônicaRatos WistarAnimaisMasculinoFemininoRatosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGomes, Ana Thereza et al Capillaria hepatica.pdfGomes, Ana Thereza et al Capillaria hepatica.pdfapplication/pdf1073054https://www.arca.fiocruz.br/bitstream/icict/5948/1/Gomes%2c%20Ana%20Thereza%20et%20al%20%20Capillaria%20hepatica.pdf53ff05a2ad1f41c98c37447c63a796b3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81949https://www.arca.fiocruz.br/bitstream/icict/5948/2/license.txtaad6e5ff39a8b3723a1981fb3bcd1becMD52TEXTGomes, Ana Thereza et al Capillaria hepatica.pdf.txtGomes, Ana Thereza et al Capillaria hepatica.pdf.txtExtracted texttext/plain18719https://www.arca.fiocruz.br/bitstream/icict/5948/5/Gomes%2c%20Ana%20Thereza%20et%20al%20%20Capillaria%20hepatica.pdf.txt7cc46b40b0d9788fdabdfd3c37986190MD55THUMBNAILGomes, Ana Thereza et al Capillaria hepatica.pdf.jpgGomes, Ana Thereza et al Capillaria hepatica.pdf.jpgGenerated Thumbnailimage/jpeg2365https://www.arca.fiocruz.br/bitstream/icict/5948/4/Gomes%2c%20Ana%20Thereza%20et%20al%20%20Capillaria%20hepatica.pdf.jpga216660a22f686c9f8fcbb869e7ab48cMD54icict/59482023-03-15 14:33:12.466oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
title Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
spellingShingle Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
Gomes, Ana Thereza
Capillaria hepatica
Septal fibrosis
Rats
Corticosteroids
Antigenic stimulation
Cirrose Hepática Experimental/parasitologia
Infecções por Enoplida/parasitologia
Capillaria/imunologia
Anticorpos Anti-Helmínticos/sangue
Antígenos de Helmintos/administração & dosagem
Cirrose Hepática Experimental/quimioterapia
Cirrose Hepática Experimental/imunologia
Infecções por Enoplida/quimioterapia
Infecções por Enoplida/imunologia
Índice de Gravidade de Doença
Modelos Animais de Doenças
Hidroxiprolina/análise
Glucocorticóides/uso terapêutico
Prednisona/uso terapêutico
Doença Crônica
Ratos Wistar
Animais
Masculino
Feminino
Ratos
title_short Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
title_full Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
title_fullStr Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
title_full_unstemmed Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
title_sort Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
author Gomes, Ana Thereza
author_facet Gomes, Ana Thereza
Cunha, Liliane Monteiro
Bastos, Carla Guimarães
Medrado, Bruno Frederico
Assis, Bárbara Cristina Alves de
Andrade, Zilton de Araújo
author_role author
author2 Cunha, Liliane Monteiro
Bastos, Carla Guimarães
Medrado, Bruno Frederico
Assis, Bárbara Cristina Alves de
Andrade, Zilton de Araújo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Ana Thereza
Cunha, Liliane Monteiro
Bastos, Carla Guimarães
Medrado, Bruno Frederico
Assis, Bárbara Cristina Alves de
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Capillaria hepatica
Septal fibrosis
Rats
Corticosteroids
Antigenic stimulation
topic Capillaria hepatica
Septal fibrosis
Rats
Corticosteroids
Antigenic stimulation
Cirrose Hepática Experimental/parasitologia
Infecções por Enoplida/parasitologia
Capillaria/imunologia
Anticorpos Anti-Helmínticos/sangue
Antígenos de Helmintos/administração & dosagem
Cirrose Hepática Experimental/quimioterapia
Cirrose Hepática Experimental/imunologia
Infecções por Enoplida/quimioterapia
Infecções por Enoplida/imunologia
Índice de Gravidade de Doença
Modelos Animais de Doenças
Hidroxiprolina/análise
Glucocorticóides/uso terapêutico
Prednisona/uso terapêutico
Doença Crônica
Ratos Wistar
Animais
Masculino
Feminino
Ratos
dc.subject.decs.pt_BR.fl_str_mv Cirrose Hepática Experimental/parasitologia
Infecções por Enoplida/parasitologia
Capillaria/imunologia
Anticorpos Anti-Helmínticos/sangue
Antígenos de Helmintos/administração & dosagem
Cirrose Hepática Experimental/quimioterapia
Cirrose Hepática Experimental/imunologia
Infecções por Enoplida/quimioterapia
Infecções por Enoplida/imunologia
Índice de Gravidade de Doença
Modelos Animais de Doenças
Hidroxiprolina/análise
Glucocorticóides/uso terapêutico
Prednisona/uso terapêutico
Doença Crônica
Ratos Wistar
Animais
Masculino
Feminino
Ratos
description Universidade Federal da Bahia. Faculdade de Medicina. Salvador, Bahia, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2012-12-10T17:51:06Z
dc.date.available.fl_str_mv 2012-12-10T17:51:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, A. T. et al. Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses. Memórias do Instituto Oswaldo Cruz, v. 101, n. 8, p. 895-898, dec. 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5948
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv GOMES, A. T. et al. Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses. Memórias do Instituto Oswaldo Cruz, v. 101, n. 8, p. 895-898, dec. 2006.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5948
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/5948/1/Gomes%2c%20Ana%20Thereza%20et%20al%20%20Capillaria%20hepatica.pdf
https://www.arca.fiocruz.br/bitstream/icict/5948/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/5948/5/Gomes%2c%20Ana%20Thereza%20et%20al%20%20Capillaria%20hepatica.pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/5948/4/Gomes%2c%20Ana%20Thereza%20et%20al%20%20Capillaria%20hepatica.pdf.jpg
bitstream.checksum.fl_str_mv 53ff05a2ad1f41c98c37447c63a796b3
aad6e5ff39a8b3723a1981fb3bcd1bec
7cc46b40b0d9788fdabdfd3c37986190
a216660a22f686c9f8fcbb869e7ab48c
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324921173016576

Registros relacionados