Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones

Detalhes bibliográficos
Autor(a) principal: Reis, Camilla Moretto dos
Data de Publicação: 2011
Outros Autores: Pereira, Danilo Sousa, Paiva, Rojane de Oliveira, Kneipp, Lucimar Ferreira, Echevarria, Aurea
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18709
Resumo: Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.
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spelling Reis, Camilla Moretto dosPereira, Danilo SousaPaiva, Rojane de OliveiraKneipp, Lucimar FerreiraEchevarria, Aurea2017-05-02T14:38:57Z2017-05-02T14:38:57Z2011REIS, Camilla Moretto dos; et al. Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones. Moleculaes, v.16, p.10668-10684, 2011.1420-3049https://www.arca.fiocruz.br/handle/icict/1870910.3390/molecules161210668engMDPIAtividade antifúngicaIrradiação por microondasTiosemicarbazonaTiosemicarbazidathiosemicarbazonethiosemicarbazidemicrowave irradiationantifungal activityMicrowave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazonesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micologia. Rio de Janeiro, RJ. Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.We present an efficient procedure for the synthesis of thirty-six N₁,N₄-substituted thiosemicarbazones, including twenty-five ones that are reported for the first time, using a microwave-assisted methodology for the reaction of thiosemicarbazide intermediates with aldehydes in the presence of glacial acetic acid in ethanol and under solvent free conditions. Overall reaction times (20-40 min when ethanol as solvent, and 3 min under solvent free conditions) were much shorter than with the traditional procedure (480 min); satisfactory yields and high-purity compounds were obtained. The thiosemicarbazide intermediates were obtained from alkyl or aryl isothiocyanates and hydrazine hydrate or phenyl hydrazine by stirring at room temperature for 60 min or by microwave irradiation for 30 min, with lower yields for the latter. The preliminary in vitro antifungal activity of thiosemicarbazones was evaluated against Aspergillus parasiticus and Candida albicans.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18709/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALlucimar2_kneipp_etal_IOC_2012.pdflucimar2_kneipp_etal_IOC_2012.pdfapplication/pdf263281https://www.arca.fiocruz.br/bitstream/icict/18709/2/lucimar2_kneipp_etal_IOC_2012.pdf11e5c628388c3e838fa559088f35c1c7MD52TEXTlucimar2_kneipp_etal_IOC_2012.pdf.txtlucimar2_kneipp_etal_IOC_2012.pdf.txtExtracted texttext/plain51595https://www.arca.fiocruz.br/bitstream/icict/18709/3/lucimar2_kneipp_etal_IOC_2012.pdf.txt824ecada5b8581aee82abf4c58e22253MD53icict/187092023-09-14 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dc.title.pt_BR.fl_str_mv Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
title Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
spellingShingle Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
Reis, Camilla Moretto dos
Atividade antifúngica
Irradiação por microondas
Tiosemicarbazona
Tiosemicarbazida
thiosemicarbazone
thiosemicarbazide
microwave irradiation
antifungal activity
title_short Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
title_full Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
title_fullStr Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
title_full_unstemmed Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
title_sort Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
author Reis, Camilla Moretto dos
author_facet Reis, Camilla Moretto dos
Pereira, Danilo Sousa
Paiva, Rojane de Oliveira
Kneipp, Lucimar Ferreira
Echevarria, Aurea
author_role author
author2 Pereira, Danilo Sousa
Paiva, Rojane de Oliveira
Kneipp, Lucimar Ferreira
Echevarria, Aurea
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Reis, Camilla Moretto dos
Pereira, Danilo Sousa
Paiva, Rojane de Oliveira
Kneipp, Lucimar Ferreira
Echevarria, Aurea
dc.subject.other.pt_BR.fl_str_mv Atividade antifúngica
Irradiação por microondas
Tiosemicarbazona
Tiosemicarbazida
topic Atividade antifúngica
Irradiação por microondas
Tiosemicarbazona
Tiosemicarbazida
thiosemicarbazone
thiosemicarbazide
microwave irradiation
antifungal activity
dc.subject.en.pt_BR.fl_str_mv thiosemicarbazone
thiosemicarbazide
microwave irradiation
antifungal activity
description Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2017-05-02T14:38:57Z
dc.date.available.fl_str_mv 2017-05-02T14:38:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, Camilla Moretto dos; et al. Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones. Moleculaes, v.16, p.10668-10684, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18709
dc.identifier.issn.pt_BR.fl_str_mv 1420-3049
dc.identifier.eissn.none.fl_str_mv 10.3390/molecules161210668
identifier_str_mv REIS, Camilla Moretto dos; et al. Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones. Moleculaes, v.16, p.10668-10684, 2011.
1420-3049
10.3390/molecules161210668
url https://www.arca.fiocruz.br/handle/icict/18709
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv MDPI
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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