Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18709 |
Resumo: | Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil. |
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Reis, Camilla Moretto dosPereira, Danilo SousaPaiva, Rojane de OliveiraKneipp, Lucimar FerreiraEchevarria, Aurea2017-05-02T14:38:57Z2017-05-02T14:38:57Z2011REIS, Camilla Moretto dos; et al. Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones. Moleculaes, v.16, p.10668-10684, 2011.1420-3049https://www.arca.fiocruz.br/handle/icict/1870910.3390/molecules161210668engMDPIAtividade antifúngicaIrradiação por microondasTiosemicarbazonaTiosemicarbazidathiosemicarbazonethiosemicarbazidemicrowave irradiationantifungal activityMicrowave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazonesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Micologia. Rio de Janeiro, RJ. Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.We present an efficient procedure for the synthesis of thirty-six N₁,N₄-substituted thiosemicarbazones, including twenty-five ones that are reported for the first time, using a microwave-assisted methodology for the reaction of thiosemicarbazide intermediates with aldehydes in the presence of glacial acetic acid in ethanol and under solvent free conditions. Overall reaction times (20-40 min when ethanol as solvent, and 3 min under solvent free conditions) were much shorter than with the traditional procedure (480 min); satisfactory yields and high-purity compounds were obtained. The thiosemicarbazide intermediates were obtained from alkyl or aryl isothiocyanates and hydrazine hydrate or phenyl hydrazine by stirring at room temperature for 60 min or by microwave irradiation for 30 min, with lower yields for the latter. The preliminary in vitro antifungal activity of thiosemicarbazones was evaluated against Aspergillus parasiticus and Candida albicans.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18709/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALlucimar2_kneipp_etal_IOC_2012.pdflucimar2_kneipp_etal_IOC_2012.pdfapplication/pdf263281https://www.arca.fiocruz.br/bitstream/icict/18709/2/lucimar2_kneipp_etal_IOC_2012.pdf11e5c628388c3e838fa559088f35c1c7MD52TEXTlucimar2_kneipp_etal_IOC_2012.pdf.txtlucimar2_kneipp_etal_IOC_2012.pdf.txtExtracted texttext/plain51595https://www.arca.fiocruz.br/bitstream/icict/18709/3/lucimar2_kneipp_etal_IOC_2012.pdf.txt824ecada5b8581aee82abf4c58e22253MD53icict/187092023-09-14 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| dc.title.pt_BR.fl_str_mv |
Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones |
| title |
Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones |
| spellingShingle |
Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones Reis, Camilla Moretto dos Atividade antifúngica Irradiação por microondas Tiosemicarbazona Tiosemicarbazida thiosemicarbazone thiosemicarbazide microwave irradiation antifungal activity |
| title_short |
Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones |
| title_full |
Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones |
| title_fullStr |
Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones |
| title_full_unstemmed |
Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones |
| title_sort |
Microwave-assisted synthesis of new N₁,N₄-substituted thiosemicarbazones |
| author |
Reis, Camilla Moretto dos |
| author_facet |
Reis, Camilla Moretto dos Pereira, Danilo Sousa Paiva, Rojane de Oliveira Kneipp, Lucimar Ferreira Echevarria, Aurea |
| author_role |
author |
| author2 |
Pereira, Danilo Sousa Paiva, Rojane de Oliveira Kneipp, Lucimar Ferreira Echevarria, Aurea |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Reis, Camilla Moretto dos Pereira, Danilo Sousa Paiva, Rojane de Oliveira Kneipp, Lucimar Ferreira Echevarria, Aurea |
| dc.subject.other.pt_BR.fl_str_mv |
Atividade antifúngica Irradiação por microondas Tiosemicarbazona Tiosemicarbazida |
| topic |
Atividade antifúngica Irradiação por microondas Tiosemicarbazona Tiosemicarbazida thiosemicarbazone thiosemicarbazide microwave irradiation antifungal activity |
| dc.subject.en.pt_BR.fl_str_mv |
thiosemicarbazone thiosemicarbazide microwave irradiation antifungal activity |
| description |
Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil. |
| publishDate |
2011 |
| dc.date.issued.fl_str_mv |
2011 |
| dc.date.accessioned.fl_str_mv |
2017-05-02T14:38:57Z |
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2017-05-02T14:38:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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REIS, Camilla Moretto dos; et al. Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones. Moleculaes, v.16, p.10668-10684, 2011. |
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https://www.arca.fiocruz.br/handle/icict/18709 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1420-3049 |
| dc.identifier.eissn.none.fl_str_mv |
10.3390/molecules161210668 |
| identifier_str_mv |
REIS, Camilla Moretto dos; et al. Microwave-Assisted Synthesis of New N1,N4-Substituted Thiosemicarbazones. Moleculaes, v.16, p.10668-10684, 2011. 1420-3049 10.3390/molecules161210668 |
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MDPI |
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