Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet

Detalhes bibliográficos
Autor(a) principal: Neves, Renata Heisler
Data de Publicação: 2006
Outros Autores: Alencar, Alba Cristina Miranda de Barros, Aguila, Marcia Barbosa, Lacerda, Carlos Alberto Mandarim de, Silva, José Roberto Machado, Gomes, Delir Corrêa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36649
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.
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spelling Neves, Renata HeislerAlencar, Alba Cristina Miranda de BarrosAguila, Marcia BarbosaLacerda, Carlos Alberto Mandarim deSilva, José Roberto MachadoGomes, Delir Corrêa2019-10-22T15:52:55Z2019-10-22T15:52:55Z2006NEVES, Renata Heisler et al. Hepatic stereology of schistosomiasis mansoni infected-mice fed a high-fat diet. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, Suppl. I, p. 253-260, 2006.0074-0276https://www.arca.fiocruz.br/handle/icict/3664910.1590/s0074-027620060009000391678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzSchistosoma mansoniEstereologiaFígadoDieta rica em gorduraRatosSchistosoma mansoniStereologyLiverHigh-fat dietMiceHepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat dietinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Patologia e Laboratórios. Laboratório de Helmintologia Romero Lascasas Porto. Disciplina de Parasitologia. Ri de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Laboratório de Morfometria e Morfologia Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Laboratório de Morfometria e Morfologia Cardiovascular. Rio de Janeiro, RJ, BrasilUniversidade do Estado do Rio de Janeiro. Departamento de Patologia e Laboratórios. Laboratório de Helmintologia Romero Lascasas Porto. Disciplina de Parasitologia. Ri de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.High-fat diets induce weight gain and fatty liver in wild-type mice. Schistosomiasis mansoni infection also promotes hepatic injury. This study was designed to quantify hepatic alterations in schistosomiasis mansoni-infected mice fed a high fat-rich chow compared to mice fed a standard rodent chow, using stereology. Female SW mice fed each either high-fat diet (29% lipids) or standard chow (12% lipids) over 8 months, and then were infected with Schistosoma mansoni cercariae. Four experimental groups were studied: infected mice fed a high-fat diet (IHFC) or standard chow (ISC), uninfected mice fed a high-fat diet (HFC) or standard chow (SC). Mice were sacrificed during early infection (9 weeks from exposure). The following hepatic biometry and the stereology parameters were determined: volume density (hepatocytes [h], sinusoids [s], steatosis [st] and hepatic fibrosis [hf]); numerical density (hepatocyte nuclei - Nv[h]); absolute number of total hepatocyte N[h], normal hepatocyte N[nh], and binucleated hepatocyte N[bh], percentage of normal hepatocyte P[nh] and binucleated hepatocyte P[bh]. IHFC and HFC groups exhibited TC, HDL-C, LDL-C, and body mass significantly greater (p < 0.05) than control group. No significant differences were found regards liver volume (p = 0.07). Significant differences were observed regards P[nh] (p = 0.0045), P[bh] (p = 0.0045), Nv[h] (p = 0.0006), N[h] (p = 0.0125), N[bh] (p = 0.0164) and N[nh] (p = 0.0078). IHFC mice group presented 29% of binucleated hepatocytes compared to HFC group (19%), ISC group (17%) and SC (6%). Volume density was significantly different between groups: Vv[h] (p = 0.0052), Vv[s] (p = 0.0025), Vv[st] (p = 0.0004), and Vv[hf] (p = 0.0007). In conclusion, schistosomiasis mansoni infection with concurrent high-fat diet promotes intensive quantitative changes in hepatic structure, contributing to an increasing on hepatic regeneration.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36649/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRenataHNeves_DelirGomes_etal_IOC_2006.pdfRenataHNeves_DelirGomes_etal_IOC_2006.pdfapplication/pdf2985301https://www.arca.fiocruz.br/bitstream/icict/36649/2/RenataHNeves_DelirGomes_etal_IOC_2006.pdfd376959b4e33680068cd5fc51381fd32MD52TEXTRenataHNeves_DelirGomes_etal_IOC_2006.pdf.txtRenataHNeves_DelirGomes_etal_IOC_2006.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
title Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
spellingShingle Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
Neves, Renata Heisler
Schistosoma mansoni
Estereologia
Fígado
Dieta rica em gordura
Ratos
Schistosoma mansoni
Stereology
Liver
High-fat diet
Mice
title_short Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
title_full Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
title_fullStr Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
title_full_unstemmed Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
title_sort Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat diet
author Neves, Renata Heisler
author_facet Neves, Renata Heisler
Alencar, Alba Cristina Miranda de Barros
Aguila, Marcia Barbosa
Lacerda, Carlos Alberto Mandarim de
Silva, José Roberto Machado
Gomes, Delir Corrêa
author_role author
author2 Alencar, Alba Cristina Miranda de Barros
Aguila, Marcia Barbosa
Lacerda, Carlos Alberto Mandarim de
Silva, José Roberto Machado
Gomes, Delir Corrêa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Neves, Renata Heisler
Alencar, Alba Cristina Miranda de Barros
Aguila, Marcia Barbosa
Lacerda, Carlos Alberto Mandarim de
Silva, José Roberto Machado
Gomes, Delir Corrêa
dc.subject.other.pt_BR.fl_str_mv Schistosoma mansoni
Estereologia
Fígado
Dieta rica em gordura
Ratos
topic Schistosoma mansoni
Estereologia
Fígado
Dieta rica em gordura
Ratos
Schistosoma mansoni
Stereology
Liver
High-fat diet
Mice
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Stereology
Liver
High-fat diet
Mice
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Helmintologia. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2019-10-22T15:52:55Z
dc.date.available.fl_str_mv 2019-10-22T15:52:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NEVES, Renata Heisler et al. Hepatic stereology of schistosomiasis mansoni infected-mice fed a high-fat diet. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, Suppl. I, p. 253-260, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36649
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762006000900039
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv NEVES, Renata Heisler et al. Hepatic stereology of schistosomiasis mansoni infected-mice fed a high-fat diet. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, Suppl. I, p. 253-260, 2006.
0074-0276
10.1590/s0074-02762006000900039
1678-8060
url https://www.arca.fiocruz.br/handle/icict/36649
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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