Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet

Detalhes bibliográficos
Autor(a) principal: Barros, L. A.
Data de Publicação: 2009
Outros Autores: Silva, M. Costa, Biolchini, C. L., Neves, R. H., Silva, J. R. Machado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29080
Resumo: Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.
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spelling Barros, L. A.Silva, M. CostaBiolchini, C. L.Neves, R. H.Silva, J. R. Machado2018-09-26T16:45:06Z2018-09-26T16:45:06Z2009BARROS, L. A. et al. Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet. Brazilian Journal of Medical and Biological Research, v. 42, p. 812-815, Sept. 2009.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/2908010.1590/s0100-879x20090009000071414-431XengAssociação Brasileira de Divulgação CientíficaSchistosoma mansoniPraziquantelDieta com Restrição de ProteínasEstereologiaSchistosoma mansoniLow-protein dietStereologyPraziquantelEffect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein dietinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, BrasilA study was undertaken to investigate the effect of administering praziquantel (PZQ), focusing on the liver stereological findings of malnourished mice infected with Schistosoma mansoni. Thirty female Swiss Webster mice (age: 21 days; weight: 8-14 g) were fed either a low-protein diet (8%) or standard chow (22% protein) for 15 days. Five mice in each group were infected with 50 cercariae each of the BH strain (Brazil). PZQ therapy (80 mg/kg body weight, per day) was started on the 50th day of infection and consisted of daily administration for 5 days. Volume density (hepatocytes, sinusoids and hepatic fibrosis) was determined by stereology using a light microscope. Body weight gain and total serum albumin levels were always lower in undernourished mice. Our stereological study demonstrated that treatment increased both volume density of hepatocytes in mice fed standard chow (47.56%, treated group and 12.06%, control) and low-protein chow (30.98%, treated group and 21.44%, control), and hepatic sinusoids [standard chow (12.52%, treated group and 9.06%, control), low-protein chow (14.42%, treated group and 8.46%, control)], while hepatic fibrosis was reduced [standard chow (39.92%, treated group and 78.88%, control) and low-protein chow (54.60%, treated group and 70.10%, control)]. On the other hand, mice fed low-protein chow decreased density volume of hepatocytes and hepatic fibrosis. In conclusion, our findings indicate that treatment with PZQ ameliorates hepatic schistosomiasis pathology even in mice fed a low-protein diet.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29080/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRH_neves_etal_IOC_2009.pdf.pdfRH_neves_etal_IOC_2009.pdf.pdfapplication/pdf387513https://www.arca.fiocruz.br/bitstream/icict/29080/2/RH_neves_etal_IOC_2009.pdf.pdfa4f2f7f0efc3b91d4176108d50aa5fe4MD52TEXTRH_neves_etal_IOC_2009.pdf.pdf.txtRH_neves_etal_IOC_2009.pdf.pdf.txtExtracted texttext/plain19843https://www.arca.fiocruz.br/bitstream/icict/29080/3/RH_neves_etal_IOC_2009.pdf.pdf.txtcd58ab5487f4a4632aa851f48147d5b1MD53icict/290802023-07-05 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dc.title.pt_BR.fl_str_mv Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
title Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
spellingShingle Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
Barros, L. A.
Schistosoma mansoni
Praziquantel
Dieta com Restrição de Proteínas
Estereologia
Schistosoma mansoni
Low-protein diet
Stereology
Praziquantel
title_short Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
title_full Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
title_fullStr Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
title_full_unstemmed Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
title_sort Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet
author Barros, L. A.
author_facet Barros, L. A.
Silva, M. Costa
Biolchini, C. L.
Neves, R. H.
Silva, J. R. Machado
author_role author
author2 Silva, M. Costa
Biolchini, C. L.
Neves, R. H.
Silva, J. R. Machado
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Barros, L. A.
Silva, M. Costa
Biolchini, C. L.
Neves, R. H.
Silva, J. R. Machado
dc.subject.other.pt_BR.fl_str_mv Schistosoma mansoni
Praziquantel
Dieta com Restrição de Proteínas
Estereologia
topic Schistosoma mansoni
Praziquantel
Dieta com Restrição de Proteínas
Estereologia
Schistosoma mansoni
Low-protein diet
Stereology
Praziquantel
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Low-protein diet
Stereology
Praziquantel
description Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-09-26T16:45:06Z
dc.date.available.fl_str_mv 2018-09-26T16:45:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARROS, L. A. et al. Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet. Brazilian Journal of Medical and Biological Research, v. 42, p. 812-815, Sept. 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29080
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.doi.none.fl_str_mv 10.1590/s0100-879x2009000900007
dc.identifier.eissn.none.fl_str_mv 1414-431X
identifier_str_mv BARROS, L. A. et al. Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet. Brazilian Journal of Medical and Biological Research, v. 42, p. 812-815, Sept. 2009.
0100-879X
10.1590/s0100-879x2009000900007
1414-431X
url https://www.arca.fiocruz.br/handle/icict/29080
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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