In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9543 |
Resumo: | Universidade Federal de São João Del-Rei. Divinópolis, MG, Brasil |
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Oliveira, Graziela Teixeira deFerreira, Jaqueline Maria SiqueiraRosa, Luiz HenriqueSiqueira Filho, Ezequias Pessoa deJohann, SusanaLima, Luciana Alves Rodrigues dos Santos2015-02-25T18:37:02Z2015-02-25T18:37:02Z2014OLIVEIRA, Graziela Teixeira de. In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Rev Soc Bras Med Trop. V. 47, n. 2, p. 247-250, 2014.0037-8682https://www.arca.fiocruz.br/handle/icict/954310.1590/0037-8682-0008-2013engSociedade Brasileira De Medicina TropicalIn vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de São João Del-Rei. Divinópolis, MG, BrasilUniversidade Federal de São João Del-Rei. Divinópolis, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrasilUniversidade Federal de São João Del-Rei. Divinópolis, MG, BrasilINTRODUCTION: There are few studies reporting the antifungal activities of Lippia alba extracts. METHODS: A broth microdilution assay was used to evaluate the antifungal effects of Lippia alba extracts against seven yeast species of Candida and Cryptococcus. The butanol fraction was investigated by gas chromatography-mass spectrometry. RESULTS: The butanol fraction showed the highest activity against Candida glabrata. The fraction also acted synergistically with itraconazole and fluconazole against C. glabrata. The dominant compounds in the butanol fraction were 2,2,5-trimethyl-3,4-hexanedione, 3,5-dimethyl-4-octanone and hexadecane. CONCLUSIONS: The butanol fraction may be a good candidate in the search for new drugs from natural products with antifungal activityLippia albaAntifungal activityYeastinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9543/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_101.pdf2014_101.pdfapplication/pdf708287https://www.arca.fiocruz.br/bitstream/icict/9543/2/2014_101.pdfb0aade9c9089b0bd83a00120e5ecd50bMD52TEXT2014_101.pdf.txt2014_101.pdf.txtExtracted texttext/plain20761https://www.arca.fiocruz.br/bitstream/icict/9543/3/2014_101.pdf.txt1d89469db9886236a6df5662e8c523cdMD53icict/95432019-06-19 10:06:32.854oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:06:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. |
title |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. |
spellingShingle |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Oliveira, Graziela Teixeira de Lippia alba Antifungal activity Yeast |
title_short |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. |
title_full |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. |
title_fullStr |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. |
title_full_unstemmed |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. |
title_sort |
In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. |
author |
Oliveira, Graziela Teixeira de |
author_facet |
Oliveira, Graziela Teixeira de Ferreira, Jaqueline Maria Siqueira Rosa, Luiz Henrique Siqueira Filho, Ezequias Pessoa de Johann, Susana Lima, Luciana Alves Rodrigues dos Santos |
author_role |
author |
author2 |
Ferreira, Jaqueline Maria Siqueira Rosa, Luiz Henrique Siqueira Filho, Ezequias Pessoa de Johann, Susana Lima, Luciana Alves Rodrigues dos Santos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Graziela Teixeira de Ferreira, Jaqueline Maria Siqueira Rosa, Luiz Henrique Siqueira Filho, Ezequias Pessoa de Johann, Susana Lima, Luciana Alves Rodrigues dos Santos |
dc.subject.en.pt_BR.fl_str_mv |
Lippia alba Antifungal activity Yeast |
topic |
Lippia alba Antifungal activity Yeast |
description |
Universidade Federal de São João Del-Rei. Divinópolis, MG, Brasil |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-02-25T18:37:02Z |
dc.date.available.fl_str_mv |
2015-02-25T18:37:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Graziela Teixeira de. In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Rev Soc Bras Med Trop. V. 47, n. 2, p. 247-250, 2014. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/9543 |
dc.identifier.issn.none.fl_str_mv |
0037-8682 |
dc.identifier.doi.none.fl_str_mv |
10.1590/0037-8682-0008-2013 |
identifier_str_mv |
OLIVEIRA, Graziela Teixeira de. In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Rev Soc Bras Med Trop. V. 47, n. 2, p. 247-250, 2014. 0037-8682 10.1590/0037-8682-0008-2013 |
url |
https://www.arca.fiocruz.br/handle/icict/9543 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira De Medicina Tropical |
publisher.none.fl_str_mv |
Sociedade Brasileira De Medicina Tropical |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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