In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.

Detalhes bibliográficos
Autor(a) principal: Oliveira, Graziela Teixeira de
Data de Publicação: 2014
Outros Autores: Ferreira, Jaqueline Maria Siqueira, Rosa, Luiz Henrique, Siqueira Filho, Ezequias Pessoa de, Johann, Susana, Lima, Luciana Alves Rodrigues dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9543
Resumo: Universidade Federal de São João Del-Rei. Divinópolis, MG, Brasil
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spelling Oliveira, Graziela Teixeira deFerreira, Jaqueline Maria SiqueiraRosa, Luiz HenriqueSiqueira Filho, Ezequias Pessoa deJohann, SusanaLima, Luciana Alves Rodrigues dos Santos2015-02-25T18:37:02Z2015-02-25T18:37:02Z2014OLIVEIRA, Graziela Teixeira de. In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Rev Soc Bras Med Trop. V. 47, n. 2, p. 247-250, 2014.0037-8682https://www.arca.fiocruz.br/handle/icict/954310.1590/0037-8682-0008-2013engSociedade Brasileira De Medicina TropicalIn vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de São João Del-Rei. Divinópolis, MG, BrasilUniversidade Federal de São João Del-Rei. Divinópolis, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrasilUniversidade Federal de São João Del-Rei. Divinópolis, MG, BrasilINTRODUCTION: There are few studies reporting the antifungal activities of Lippia alba extracts. METHODS: A broth microdilution assay was used to evaluate the antifungal effects of Lippia alba extracts against seven yeast species of Candida and Cryptococcus. The butanol fraction was investigated by gas chromatography-mass spectrometry. RESULTS: The butanol fraction showed the highest activity against Candida glabrata. The fraction also acted synergistically with itraconazole and fluconazole against C. glabrata. The dominant compounds in the butanol fraction were 2,2,5-trimethyl-3,4-hexanedione, 3,5-dimethyl-4-octanone and hexadecane. CONCLUSIONS: The butanol fraction may be a good candidate in the search for new drugs from natural products with antifungal activityLippia albaAntifungal activityYeastinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9543/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_101.pdf2014_101.pdfapplication/pdf708287https://www.arca.fiocruz.br/bitstream/icict/9543/2/2014_101.pdfb0aade9c9089b0bd83a00120e5ecd50bMD52TEXT2014_101.pdf.txt2014_101.pdf.txtExtracted texttext/plain20761https://www.arca.fiocruz.br/bitstream/icict/9543/3/2014_101.pdf.txt1d89469db9886236a6df5662e8c523cdMD53icict/95432019-06-19 10:06:32.854oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:06:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
title In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
spellingShingle In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
Oliveira, Graziela Teixeira de
Lippia alba
Antifungal activity
Yeast
title_short In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
title_full In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
title_fullStr In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
title_full_unstemmed In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
title_sort In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species.
author Oliveira, Graziela Teixeira de
author_facet Oliveira, Graziela Teixeira de
Ferreira, Jaqueline Maria Siqueira
Rosa, Luiz Henrique
Siqueira Filho, Ezequias Pessoa de
Johann, Susana
Lima, Luciana Alves Rodrigues dos Santos
author_role author
author2 Ferreira, Jaqueline Maria Siqueira
Rosa, Luiz Henrique
Siqueira Filho, Ezequias Pessoa de
Johann, Susana
Lima, Luciana Alves Rodrigues dos Santos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Graziela Teixeira de
Ferreira, Jaqueline Maria Siqueira
Rosa, Luiz Henrique
Siqueira Filho, Ezequias Pessoa de
Johann, Susana
Lima, Luciana Alves Rodrigues dos Santos
dc.subject.en.pt_BR.fl_str_mv Lippia alba
Antifungal activity
Yeast
topic Lippia alba
Antifungal activity
Yeast
description Universidade Federal de São João Del-Rei. Divinópolis, MG, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-02-25T18:37:02Z
dc.date.available.fl_str_mv 2015-02-25T18:37:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Graziela Teixeira de. In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Rev Soc Bras Med Trop. V. 47, n. 2, p. 247-250, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9543
dc.identifier.issn.none.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0008-2013
identifier_str_mv OLIVEIRA, Graziela Teixeira de. In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Rev Soc Bras Med Trop. V. 47, n. 2, p. 247-250, 2014.
0037-8682
10.1590/0037-8682-0008-2013
url https://www.arca.fiocruz.br/handle/icict/9543
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Sociedade Brasileira De Medicina Tropical
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