Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection

Detalhes bibliográficos
Autor(a) principal: Fonseca, Lea Mirian Barbosa
Data de Publicação: 2011
Outros Autores: Xavier, Sergio S., Castro, Paulo Henrique Rosado de, Lima, Ronaldo S. L., Gutfilen, Bianca, Goldenberg, Regina C. S., Maiolino, Angelo, Chagas, Claudia L. R., Pedrosa, Roberto C., Carvalho, Antonio Carlos Campos de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37521
Resumo: 2020-12-02
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spelling Fonseca, Lea Mirian BarbosaXavier, Sergio S.Castro, Paulo Henrique Rosado deLima, Ronaldo S. L.Gutfilen, BiancaGoldenberg, Regina C. S.Maiolino, AngeloChagas, Claudia L. R.Pedrosa, Roberto C.Carvalho, Antonio Carlos Campos de2019-12-02T13:54:41Z2019-12-02T13:54:41Z2011FONSECA, Lea Mirian Barbosa et al. Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection. International Journal of Cardiology, v. 149, p. 310-314, 2011.0167-5273https://www.arca.fiocruz.br/handle/icict/3752110.1016/j.ijcard.2010.02.008engElsevierBiodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-12-02Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Department of Radiology. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Evandro Chagas. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Department of Cardiology. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Department of Radiology. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Department of Cardiology. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Department of Radiology. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Cardiologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Department of Hematology,. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Department of Radiology. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Department of Cardiology. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Cardiologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Background: Animal and human clinical studies have indicated that bone marrow (BM) mononuclear cell (MNC) therapy for Chagasic Cardiomyopathy (ChC) is feasible, safe and potentially efficacious. Nevertheless, little is known about the retention of these cells after intracoronary (IC) infusion. Methods: Our study investigated the homing of technetium-99m (99mTc) labeled BM MNCs and compared itto thallium-201 (201Tl) myocardial perfusion images using the standard 17-segment model. Six patients with congestive heart failure of chagasic etiology were included. Results: Scintigraphic images revealed an uptake of 5.4%±1.7, 4.3%±1.5 and 2.3%±0.6 of the total infused radioactivity in the heart after 1, 3 and 24 h, respectively. The remaining activity was distributed mainly to the liver and spleen. Of 102 segments analyzed, homing took place in 36%. Segments with perfusion had greater homing (58.6%) than those with decreased or no perfusion (6.8%), p< 0.0001. There was no correlation between the number of injected cells and the number of segments with homing for each patient (r=−0.172, p=0.774). Conclusions:These results indicate that 99mTc-BM MNCs delivered by IC injection homed to the chagasicmyocardium. However, cell biodistribution was heterogeneous and limited, being strongly associated withthe myocardial perfusion pattern at rest. These initial data suggest that the IC route may present limitationsin chagasic patients and that alternative routes of cell administration may be necessary.HomingCell therapyIntracoronary infusionMyocardial ScintigraphyChagasic cardiomyopathyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37521/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Fonseca_Lea_etal_INI_2011.pdfve_Fonseca_Lea_etal_INI_2011.pdfapplication/pdf798545https://www.arca.fiocruz.br/bitstream/icict/37521/2/ve_Fonseca_Lea_etal_INI_2011.pdf8edcf4d2fc0219a960be8d7a6bf5b1c9MD52TEXTve_Fonseca_Lea_etal_INI_2011.pdf.txtve_Fonseca_Lea_etal_INI_2011.pdf.txtExtracted texttext/plain28036https://www.arca.fiocruz.br/bitstream/icict/37521/3/ve_Fonseca_Lea_etal_INI_2011.pdf.txt4b50cd0454fcafb0cf469cff7fc9ef6dMD53icict/375212021-03-24 16:32:40.236oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
title Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
spellingShingle Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
Fonseca, Lea Mirian Barbosa
Homing
Cell therapy
Intracoronary infusion
Myocardial Scintigraphy
Chagasic cardiomyopathy
title_short Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
title_full Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
title_fullStr Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
title_full_unstemmed Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
title_sort Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection
author Fonseca, Lea Mirian Barbosa
author_facet Fonseca, Lea Mirian Barbosa
Xavier, Sergio S.
Castro, Paulo Henrique Rosado de
Lima, Ronaldo S. L.
Gutfilen, Bianca
Goldenberg, Regina C. S.
Maiolino, Angelo
Chagas, Claudia L. R.
Pedrosa, Roberto C.
Carvalho, Antonio Carlos Campos de
author_role author
author2 Xavier, Sergio S.
Castro, Paulo Henrique Rosado de
Lima, Ronaldo S. L.
Gutfilen, Bianca
Goldenberg, Regina C. S.
Maiolino, Angelo
Chagas, Claudia L. R.
Pedrosa, Roberto C.
Carvalho, Antonio Carlos Campos de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Lea Mirian Barbosa
Xavier, Sergio S.
Castro, Paulo Henrique Rosado de
Lima, Ronaldo S. L.
Gutfilen, Bianca
Goldenberg, Regina C. S.
Maiolino, Angelo
Chagas, Claudia L. R.
Pedrosa, Roberto C.
Carvalho, Antonio Carlos Campos de
dc.subject.en.pt_BR.fl_str_mv Homing
Cell therapy
Intracoronary infusion
Myocardial Scintigraphy
Chagasic cardiomyopathy
topic Homing
Cell therapy
Intracoronary infusion
Myocardial Scintigraphy
Chagasic cardiomyopathy
description 2020-12-02
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-12-02T13:54:41Z
dc.date.available.fl_str_mv 2019-12-02T13:54:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Lea Mirian Barbosa et al. Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection. International Journal of Cardiology, v. 149, p. 310-314, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37521
dc.identifier.issn.pt_BR.fl_str_mv 0167-5273
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijcard.2010.02.008
identifier_str_mv FONSECA, Lea Mirian Barbosa et al. Biodistribution of bone marrow mononuclear cells in chronic chagasic cardiomyopathy after intracoronary injection. International Journal of Cardiology, v. 149, p. 310-314, 2011.
0167-5273
10.1016/j.ijcard.2010.02.008
url https://www.arca.fiocruz.br/handle/icict/37521
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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