Pathological and historical association between Guillain-Barré Syndrome (SGB) and Zika Virus infection

• Autor(a) principal: Silva, João Felipe Tinto
• Data de Publicação: 2022
• Outros Autores: Medeiros, Felipe Lima de, Mello, Emmanuella Costa de Azevedo, Sousa, Emanuel Osvaldo de, Oliveira, Ingrid Mikaela Moreira de, Araújo, Emanueli Larice Costa, Soares, Gustavo Henrique dos Santos, Lima, Tuanny Beatriz dos Santos, Souza, Thaís Ferreira Modesto, Leal, Elayne Cristina Pereira de Souza, Leitão, Darlly Tavares, Andrade, Katia Helena Marinho de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/32412
• topic: Zika virus infection; Arbovirus infections; Guillain-Barré Syndrome.; Infecciones por arbovirus; Infección por el virus del Zika; Síndorme de Guillain-Barré.; Infecção por Zika vírus; Infecções por arbovírus; Síndrome de Guillain-Barré.

Introduction: The origin of GBS is still unknown, however, it is often preceded by an infection, with reports of its relationship with Zika Virus infection. Objective: to investigate the relationship between Zika virus infection and Guillain-Barré Syndrome (GBS). Method: An integrative literature review carried out through databases indexed in the Virtual Health Library (VHL), using the descriptors: “Zika Virus Infection”, “Arbovirus Infections” and “Guillain-Barré Syndrome”. Six studies were selected. Results: The underlying pathophysiological mechanisms of GBS linked to Zika virus are unknown, although the immunological reactions described with other pathogenic microbes could have the same putative role. Furthermore, there is no valid explanation for the emergence of this complication that was not previously related to the Zika virus; one theory is that the virus has genetically evolved to a more pathogenic genotype. Final Considerations: An association between GBS and Zika virus infection is reported, and there are some hypotheses and studies carried out that aim to investigate the pathophysiology involved in this association. Despite recent studies, further studies are needed to deepen the full understanding of the mechanisms involved.