The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37926 |
Resumo: | Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Fosbøl, Emil L.Park, Lawrence P.Chu, Vivian H.Athan, EugeneDelahaye, FrançoisFreiberger, TomasLamas, CristianeMiro, José M.Strahilevitz, JacobTribouilloy, ChristopheDurante-Mangoni, EmanuelePericas, Juan M.Fernández-Hidalgo, NuriaNacinovich, FranciscoRizk, HusseinBarsic, BrunoGiannitsioti, EfthymiaHurley, John P.Hannan, Margaret M.Wang, Andrew2019-12-13T14:19:40Z2019-12-13T14:19:40Z2019FOSBØL, Emil L. et al. The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis. European Heart Journal, v. 40, p. 2243-2251, 2019.0195-668Xhttps://www.arca.fiocruz.br/handle/icict/3792610.1093/eurheartj/ehz2041522-9645Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-12-13Duke University Medical Center. Durham, NC, USA / University Hospital of Copenhagen. Department of Cardiology. Copenhagen, Denmark / Rigshospitalet. Copenhagen, Denmark.Duke University Medical Center. Durham, NC, USA.Duke University Medical Center. Durham, NC, USA.Barwon Health. Geelong, Australia / Deakin University. Geelong, Australia.Hospital Louis Pradel. Lyon-Bron, France.Centre for Cardiovascular Surgery and Transplantation. Brno, Czech Republic / Masaryk University. Central European Institute of Technology. Brno, Czech Republic.Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Rio de Janeiro, RJ, Brasil.Hospital Clinic. Infectious Diseases Service. Barcelona, Spain / IDIBAPS. Barcelona, Spain / University of Barcelona. Barcelona, Spain.Hadassah-Hebrew University Medical Center. Jerusalem, Israel.University Hospital. Amiens, France / INSERM U-1088. Amiens, France / University of Picardie. Amiens, France.University of Campania. Internal Medicine. Naples, Italy / Monaldi Hospital. Naples, Italy.Hospital Clinic. Infectious Diseases Service. Barcelona, Spain / IDIBAPS. Barcelona, Spain / University of Barcelona. Barcelona, Spain.Hospital Universitari de Barcelona. Servei de MalaltiesInfeccioses. Barcelona, Spain.Instituto Cardiovascular de Buenos Aires. Buenos Aires, Argentina.Cairo University Hospital. Cairo, Egypt.University of Zagreb. School of Medicine University of Zagreb. Zagreb, Croatia. / Hospital for Infectious Diseases. Zagreb, Croatia.Attikon University. General Hospital. Athens, Greece.Mater Misericordiae University Hospital. Dublin, Ireland.Mater Misericordiae University Hospital. Dublin, Ireland.Duke University Medical Center. Durham, NC, USA / University Hospital of Copenhagen. Department of Cardiology. Copenhagen, Denmark / Rigshospitalet. Copenhagen, Denmark.In left-sided infective endocarditis (IE), a large vegetation >10 mm is associated with higher mortality, yet it is unknown whether surgery during the acute phase opposed to medical therapy is associated with improved survival. We assessed the association between surgery and 6-month mortality as related to vegetation size.Patients with definite, left-sided IE (2008–2012) from The International Collaboration on Endocarditis prospective, multinational registry were included. We compared clinical characteristics and 6-month mortality (by Cox regression with inverse propensity of treatment weighting) between patients with vegetation size <_10 mm vs. >10 mm in maximum length by surgical treatment strategy. A total of 1006 patients with left sided IE were included; 422 with a vegetation size <_10 mm (median age 66.0 years, 33% women) and 584 (median age 58.4 years, 34% women) patients with a large vegetation >10 mm. Operative risk by STS-IE score was similar between groups. Embolic events occurred in 28.4% vs. 44.3% (P < 0.001), respectively. Patients with a vegetation >10 mm was associated with higher 6-month mortality (25.1% vs. 19.4% for small vegetation, P = 0.035). However, after propensity adjustment, the association with higher mortality persisted only in patients with a large vegetation >10 mm vs. <_10 mm: hazard ratio (HR) 1.55 (1.27–1.90); but only in patients with large vegetation managed medically [HR 1.86 (1.48–2.34)] rather than surgically [HR 1.01 (0.69–1.49)]. Left-sided IE with vegetation size >10 mm was associated with an increased mortality at 6 months in this observational study but was dependent on treatment strategy. For patients with large vegetation undergoing surgical treatment, survival was similar to patients with smaller vegetation size.engOxford University PressThe association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfective endocarditisVegetation sizeSurgeryAntibioticsOutcomesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis |
| title |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis |
| spellingShingle |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis Fosbøl, Emil L. Infective endocarditis Vegetation size Surgery Antibiotics Outcomes |
| title_short |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis |
| title_full |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis |
| title_fullStr |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis |
| title_full_unstemmed |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis |
| title_sort |
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis |
| author |
Fosbøl, Emil L. |
| author_facet |
Fosbøl, Emil L. Park, Lawrence P. Chu, Vivian H. Athan, Eugene Delahaye, François Freiberger, Tomas Lamas, Cristiane Miro, José M. Strahilevitz, Jacob Tribouilloy, Christophe Durante-Mangoni, Emanuele Pericas, Juan M. Fernández-Hidalgo, Nuria Nacinovich, Francisco Rizk, Hussein Barsic, Bruno Giannitsioti, Efthymia Hurley, John P. Hannan, Margaret M. Wang, Andrew |
| author_role |
author |
| author2 |
Park, Lawrence P. Chu, Vivian H. Athan, Eugene Delahaye, François Freiberger, Tomas Lamas, Cristiane Miro, José M. Strahilevitz, Jacob Tribouilloy, Christophe Durante-Mangoni, Emanuele Pericas, Juan M. Fernández-Hidalgo, Nuria Nacinovich, Francisco Rizk, Hussein Barsic, Bruno Giannitsioti, Efthymia Hurley, John P. Hannan, Margaret M. Wang, Andrew |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fosbøl, Emil L. Park, Lawrence P. Chu, Vivian H. Athan, Eugene Delahaye, François Freiberger, Tomas Lamas, Cristiane Miro, José M. Strahilevitz, Jacob Tribouilloy, Christophe Durante-Mangoni, Emanuele Pericas, Juan M. Fernández-Hidalgo, Nuria Nacinovich, Francisco Rizk, Hussein Barsic, Bruno Giannitsioti, Efthymia Hurley, John P. Hannan, Margaret M. Wang, Andrew |
| dc.subject.en.pt_BR.fl_str_mv |
Infective endocarditis Vegetation size Surgery Antibiotics Outcomes |
| topic |
Infective endocarditis Vegetation size Surgery Antibiotics Outcomes |
| description |
Cristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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2019 |
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2019-12-13T14:19:40Z |
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2019-12-13T14:19:40Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
FOSBØL, Emil L. et al. The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis. European Heart Journal, v. 40, p. 2243-2251, 2019. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/37926 |
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0195-668X |
| dc.identifier.doi.none.fl_str_mv |
10.1093/eurheartj/ehz204 |
| dc.identifier.eissn.none.fl_str_mv |
1522-9645 |
| identifier_str_mv |
FOSBØL, Emil L. et al. The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis. European Heart Journal, v. 40, p. 2243-2251, 2019. 0195-668X 10.1093/eurheartj/ehz204 1522-9645 |
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Oxford University Press |
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Oxford University Press |
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