The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis

Detalhes bibliográficos
Autor(a) principal: Martins, Caroline Azevedo
Data de Publicação: 2021
Outros Autores: Santos, Maria Conceição B dos, Albuquerque, Cassiano Felippe Gonçalves de, Faria Neto, Hugo Caire Castro, Faria, Mauro Velho Castro, Burth, Patricia, Younes-Ibrahim, Mauricio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46743
Resumo: Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.
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spelling Martins, Caroline AzevedoSantos, Maria Conceição B dosAlbuquerque, Cassiano Felippe Gonçalves deFaria Neto, Hugo Caire CastroFaria, Mauro Velho CastroBurth, PatriciaYounes-Ibrahim, Mauricio2021-04-16T19:50:32Z2021-04-16T19:50:32Z2021MARTINS, Caroline Azevedo et al. The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis. Helyon, v. 7, e06430, 7p, Mar. 2021.2405-8440https://www.arca.fiocruz.br/handle/icict/4674310.1016/j.heliyon.2021.e06420engElsevierResultado clínico da LeptospiroseLipotoxicidade agudaLipidomeÁcido oleico/albuminaNa/K-ATPaseLeptospirosis clinical outcomeAcute lipotoxicityLipidomeOleic acid/albuminNa/K-ATPaseThe relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasilniversidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Biologia Celular e Molecular. Laboratório de Enzimologia e Sinalização Celular. Niterói, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil / Pontifícia Universidade Católica. Departamento de Medicina. Rio de Janeiro, RJ, Brasil.Human leptospirosis is an acute infectious zoonosis presenting specific lipid disorders. Previous in vitro studies showed both leptospira glycolipoprotein endotoxin, and high oleic acid levels were associated with Na/K-ATPase inhibition that is amplified by the reduction of circulating albumin levels. In this study, we aimed to investigate the relationship of oleic acid/albumin (OA/A) molar ratio and clinical outcomes in Leptospirosis. Through a prospective observational cohort study employing high-performance liquid chromatography (HPLC) we sequen tially determined serum concentrations of nonesterified fatty acids (NEFA) and albumin in twenty-eight patients with severe leptospirosis since their hospital admission. Twenty patients recovered, and eight died. Data was distributed in two groups according to clinical outcomes. Oleic acid/albumin molar ratios (OA/A), initial samples, were higher than those in healthy donors. The ratio OA/A, however, persisted high in dying patients, whereas patients who survived had a reduction matching to healthy donors. Biochemical alterations suggest that cure is correlated to the reestablishment of the OA/A molar ratio, while fatal outcomes related to persisting OA/A im balances. Analysis by receiver operating characteristic (ROC) showed the area under the curve of 0.864 and the cutoff value of 0.715 being associated with a high odds ratio. Lipid analysis from patients with leptospirosis had an acute high serum OA/A molar ratio, and sustained imbalance has a high odds ratio and strong correlation with mortality.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46743/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCassianoAlbuquerque_HugoCCneto_etal_IOC_2021.pdfCassianoAlbuquerque_HugoCCneto_etal_IOC_2021.pdfapplication/pdf725016https://www.arca.fiocruz.br/bitstream/icict/46743/2/CassianoAlbuquerque_HugoCCneto_etal_IOC_2021.pdf2b6ef45137005bdcba0d57ac3df840efMD52TEXTCassianoAlbuquerque_HugoCCneto_etal_IOC_2021.pdf.txtCassianoAlbuquerque_HugoCCneto_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
title The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
spellingShingle The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
Martins, Caroline Azevedo
Resultado clínico da Leptospirose
Lipotoxicidade aguda
Lipidome
Ácido oleico/albumina
Na/K-ATPase
Leptospirosis clinical outcome
Acute lipotoxicity
Lipidome
Oleic acid/albumin
Na/K-ATPase
title_short The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
title_full The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
title_fullStr The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
title_full_unstemmed The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
title_sort The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis
author Martins, Caroline Azevedo
author_facet Martins, Caroline Azevedo
Santos, Maria Conceição B dos
Albuquerque, Cassiano Felippe Gonçalves de
Faria Neto, Hugo Caire Castro
Faria, Mauro Velho Castro
Burth, Patricia
Younes-Ibrahim, Mauricio
author_role author
author2 Santos, Maria Conceição B dos
Albuquerque, Cassiano Felippe Gonçalves de
Faria Neto, Hugo Caire Castro
Faria, Mauro Velho Castro
Burth, Patricia
Younes-Ibrahim, Mauricio
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Martins, Caroline Azevedo
Santos, Maria Conceição B dos
Albuquerque, Cassiano Felippe Gonçalves de
Faria Neto, Hugo Caire Castro
Faria, Mauro Velho Castro
Burth, Patricia
Younes-Ibrahim, Mauricio
dc.subject.other.pt_BR.fl_str_mv Resultado clínico da Leptospirose
Lipotoxicidade aguda
Lipidome
Ácido oleico/albumina
Na/K-ATPase
topic Resultado clínico da Leptospirose
Lipotoxicidade aguda
Lipidome
Ácido oleico/albumina
Na/K-ATPase
Leptospirosis clinical outcome
Acute lipotoxicity
Lipidome
Oleic acid/albumin
Na/K-ATPase
dc.subject.en.pt_BR.fl_str_mv Leptospirosis clinical outcome
Acute lipotoxicity
Lipidome
Oleic acid/albumin
Na/K-ATPase
description Universidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Departamento de Medicina Interna. Laboratório Integrado de Nefrologia. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-16T19:50:32Z
dc.date.available.fl_str_mv 2021-04-16T19:50:32Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINS, Caroline Azevedo et al. The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis. Helyon, v. 7, e06430, 7p, Mar. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46743
dc.identifier.issn.pt_BR.fl_str_mv 2405-8440
dc.identifier.doi.none.fl_str_mv 10.1016/j.heliyon.2021.e06420
identifier_str_mv MARTINS, Caroline Azevedo et al. The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis. Helyon, v. 7, e06430, 7p, Mar. 2021.
2405-8440
10.1016/j.heliyon.2021.e06420
url https://www.arca.fiocruz.br/handle/icict/46743
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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