Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10131 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil |
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Santos, Vania CristinaVale, Vladimir FazitoSilva, Sydnei Magno daNascimento, Alexandre Alves SousaSaab, Natalia Alvim AraujoSoares, Rodrigo Pedro PintoMichalick, Marilene Suzan MarquesAraujo, Ricardo NascimentoPereira, Marcos HoracioFujiwara, Ricardo ToshioGontijo, Nelder Figueiredo2015-04-28T16:34:21Z2015-04-28T16:34:21Z2014SANTOS, Vania Cristina et al. Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development. PLoS ONE, v. 9, n. 11, p. e111241.1932-6203https://www.arca.fiocruz.br/handle/icict/1013110.1371/journal.pone.0111241porPublic Library of ScienceHost Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Developmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Uberlandia. Instituto de Ciências Biomédicas. Uberlandia, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico. Instituto National de Ciências e Tecnologia Molecular. Brasilia, DF, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/Conselho Nacional de Desenvolvimento Cientifico e Tecnológico. Instituto Nacional de Ciências e Tecnologia Molecular. Brasilia, DF, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico. Instituto National de Ciências e Tecnologia Molecular. Brasilia, DF, BrazilSome reports have described the interference of Leishmania on sand flies physiology, and such behavior most likely evolved to favor the development and transmission of the parasite. Most of these studies showed that Leishmania could modulate the level of proteases in the midgut after an infective blood meal, and decreased proteolytic activity is indeed beneficial for the development of promastigotes in the gut of sand flies. In the present study, we performed a detailed investigation of the intestinal pH in Lutzomyia longipalpis females naturally infected with Leishmania infantum and investigated the production of trypsin by these insects using different approaches. Our results allowed us to propose a mechanism by which these parasites interfere with the physiology of L. longipalpis to decrease the production of proteolytic enzymes. According to our hypothesis L. infantum promastigotes indirectly interfere with the production of trypsin by modulating the mechanism that controls the intestinal pH via the action of a yet non-identified substance released by promastigote forms inside the midgut. This substance is not an acid, whose action would be restrict on to release H+ to the medium, but is a substance that is able to interfere with midgut physiology through a mechanism involving pH control. According to our hypothesis, as the pH decreases, the proteolytic enzymes efficiency is also reduced, leading to a decline in the supply of amino acids to the enterocytes: this decline reduces the stimulus for protease production because it is regulated by the supply of amino acids, thus leading to a delay in digestionLeishmaniaLutzomyia longipalpisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10131/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINAL2014_182.pdf2014_182.pdfapplication/pdf487782https://www.arca.fiocruz.br/bitstream/icict/10131/2/2014_182.pdf3c8917e3d7384fae4630e771220545cbMD52TEXT2014_182.pdf.txt2014_182.pdf.txtExtracted texttext/plain53774https://www.arca.fiocruz.br/bitstream/icict/10131/3/2014_182.pdf.txt2e593a4fad5b9e9364967e1040877397MD53icict/101312022-08-01 12:14:04.502oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-08-01T15:14:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development |
| title |
Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development |
| spellingShingle |
Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development Santos, Vania Cristina Leishmania Lutzomyia longipalpis |
| title_short |
Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development |
| title_full |
Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development |
| title_fullStr |
Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development |
| title_full_unstemmed |
Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development |
| title_sort |
Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development |
| author |
Santos, Vania Cristina |
| author_facet |
Santos, Vania Cristina Vale, Vladimir Fazito Silva, Sydnei Magno da Nascimento, Alexandre Alves Sousa Saab, Natalia Alvim Araujo Soares, Rodrigo Pedro Pinto Michalick, Marilene Suzan Marques Araujo, Ricardo Nascimento Pereira, Marcos Horacio Fujiwara, Ricardo Toshio Gontijo, Nelder Figueiredo |
| author_role |
author |
| author2 |
Vale, Vladimir Fazito Silva, Sydnei Magno da Nascimento, Alexandre Alves Sousa Saab, Natalia Alvim Araujo Soares, Rodrigo Pedro Pinto Michalick, Marilene Suzan Marques Araujo, Ricardo Nascimento Pereira, Marcos Horacio Fujiwara, Ricardo Toshio Gontijo, Nelder Figueiredo |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Vania Cristina Vale, Vladimir Fazito Silva, Sydnei Magno da Nascimento, Alexandre Alves Sousa Saab, Natalia Alvim Araujo Soares, Rodrigo Pedro Pinto Michalick, Marilene Suzan Marques Araujo, Ricardo Nascimento Pereira, Marcos Horacio Fujiwara, Ricardo Toshio Gontijo, Nelder Figueiredo |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania Lutzomyia longipalpis |
| topic |
Leishmania Lutzomyia longipalpis |
| description |
Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil |
| publishDate |
2014 |
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2014 |
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2015-04-28T16:34:21Z |
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2015-04-28T16:34:21Z |
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SANTOS, Vania Cristina et al. Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development. PLoS ONE, v. 9, n. 11, p. e111241. |
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https://www.arca.fiocruz.br/handle/icict/10131 |
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1932-6203 |
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10.1371/journal.pone.0111241 |
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SANTOS, Vania Cristina et al. Host Modulation by a Parasite: How Leishmania infantum Modifies the Intestinal Environment of Lutzomyia longipalpis to Favor Its Development. PLoS ONE, v. 9, n. 11, p. e111241. 1932-6203 10.1371/journal.pone.0111241 |
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