Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid

Detalhes bibliográficos
Autor(a) principal: Ribeiro Filho, Jaime
Data de Publicação: 2015
Outros Autores: Piuvezam, Márcia Regina, Bozza, Patrícia T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11521
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling Ribeiro Filho, JaimePiuvezam, Márcia ReginaBozza, Patrícia T.2015-08-19T13:49:27Z2015-08-19T13:49:27Z2015RIBEIRO FILHO, Jaime; PIUVESAM, Márcia Regina; BOZZA, Patrícia T. . Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid. Molecules, v.20, n.3, p.4695-4707, 2015.1420-3049https://www.arca.fiocruz.br/handle/icict/1152110.3390/molecules20034695engMDPIAnti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloidinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal da Paraíba. Departamento de Fisiologia e Patologia. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Curine is a bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum (Menispermaceae). Recent findings have shed light on the actions of curine in different models of allergy and inflammation. Here we review the properties and mechanisms of action of curine focusing on its anti-allergic effects. Curine pre-treatment significantly inhibited the scratching behavior, paw edema and systemic anaphylaxis induced by either ovalbumin (OVA) in sensitized animals or compound 48/80, through mechanisms of mast cell stabilization and inhibition of mast cell activation to generate lipid mediators. In addition, oral administration of curine significantly inhibited eosinophil recruitment and activation, as well as, OVA-induced airway hyper-responsiveness in a mouse model of asthma, through inhibition of the production of IL-13 and eotaxin, and of Ca2+ influx. In conclusion, curine exhibit anti-allergic effects in models of lung, skin and systemic allergy in the absence of significant toxicity, and as such has the potential for anti-allergic drug development.CurineAnti-allergicAsthmaCalciumMast cellsEosinophilsEosinófilosMastócitosAsmaCálcioinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11521/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALjaime_filhoetal_IOC_2015.pdfapplication/pdf1130453https://www.arca.fiocruz.br/bitstream/icict/11521/2/jaime_filhoetal_IOC_2015.pdf35fcb863bfedd8f6e46a2e2822d2dd32MD52TEXTjaime_filhoetal_IOC_2015.pdf.txtjaime_filhoetal_IOC_2015.pdf.txtExtracted texttext/plain40709https://www.arca.fiocruz.br/bitstream/icict/11521/3/jaime_filhoetal_IOC_2015.pdf.txt3d18f74ce5bacbec100a6ea8e562da58MD53icict/115212022-06-24 13:10:43.363oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:43Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid
title Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid
spellingShingle Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid
Ribeiro Filho, Jaime
Curine
Anti-allergic
Asthma
Calcium
Mast cells
Eosinophils
Eosinófilos
Mastócitos
Asma
Cálcio
title_short Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid
title_full Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid
title_fullStr Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid
title_full_unstemmed Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid
title_sort Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid
author Ribeiro Filho, Jaime
author_facet Ribeiro Filho, Jaime
Piuvezam, Márcia Regina
Bozza, Patrícia T.
author_role author
author2 Piuvezam, Márcia Regina
Bozza, Patrícia T.
author2_role author
author
dc.contributor.author.fl_str_mv Ribeiro Filho, Jaime
Piuvezam, Márcia Regina
Bozza, Patrícia T.
dc.subject.en.pt_BR.fl_str_mv Curine
Anti-allergic
Asthma
Calcium
Mast cells
Eosinophils
topic Curine
Anti-allergic
Asthma
Calcium
Mast cells
Eosinophils
Eosinófilos
Mastócitos
Asma
Cálcio
dc.subject.decs.pt_BR.fl_str_mv Eosinófilos
Mastócitos
Asma
Cálcio
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-08-19T13:49:27Z
dc.date.available.fl_str_mv 2015-08-19T13:49:27Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RIBEIRO FILHO, Jaime; PIUVESAM, Márcia Regina; BOZZA, Patrícia T. . Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid. Molecules, v.20, n.3, p.4695-4707, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11521
dc.identifier.issn.pt_BR.fl_str_mv 1420-3049
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/molecules20034695
identifier_str_mv RIBEIRO FILHO, Jaime; PIUVESAM, Márcia Regina; BOZZA, Patrícia T. . Anti-Allergic Properties of Curine, a Bisbenzylisoquinoline Alkaloid. Molecules, v.20, n.3, p.4695-4707, 2015.
1420-3049
10.3390/molecules20034695
url https://www.arca.fiocruz.br/handle/icict/11521
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11521/1/license.txt
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