Manson's schistosomiasis in the undernourished mouse: some recent findings

Detalhes bibliográficos
Autor(a) principal: Coutinho, Eridan M.
Data de Publicação: 2010
Outros Autores: Oliveira, Sheilla A. de, Barros, Andréia F. de, Silva, Fabiana L., Ramos, Renata P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26122
Resumo: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil.
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spelling Coutinho, Eridan M.Oliveira, Sheilla A. deBarros, Andréia F. deSilva, Fabiana L.Ramos, Renata P.2018-04-26T12:34:37Z2018-04-26T12:34:37Z2010COUTINHO, E. M. et al. Manson’s schistosomiasis in the undernourished mouse: some recent findings. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 359–366, jul. 2010.1678-8060https://www.arca.fiocruz.br/handle/icict/2612210.1590/S0074-02762010000400002engSchistosoma mansoniDesnutriçãoImunopatologiaSchistosoma mansoniUndernutritionImmunopathologyAnimaisAnticorpos, Helmintos / imunologiaCitocinas / imunologiaImunidade, Humoral / imunologiaCirrose Hepática Experimental / ImunologiaCirrose Hepática Experimental / parasitologiaCirrose Hepática Experimental / patologiaDesnutrição / imunologiaDesnutrição / patologiaRatosRatos, KnockoutModelos AnimalSchistosoma mansoni / imunologiaEsquistossomose mansoni / imunologiaEsquistossomose mansoni / patologiaManson's schistosomiasis in the undernourished mouse: some recent findingsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil.This paper deals with current knowledge of the interrelationships between Schistosoma infection and malnutrition. It emphasizes the relevance of these investigations in the face of dynamic and evolving changes occurring in population diets and changes in the epidemiological patterns of schistosomiasis in endemic countries. The paper further discusses the basis for continuing the studies on this subject and the reasons why it represents a misunderstood association. This review also focuses on the cellular and humoral immune responses in the undernourished mouse model infected with Schistosoma mansoni, with updated information on the immune response in wild-type and iNOS knockout mice concerning soluble egg antigen specific antibodies and kinetics of IFN-gamma, IL-4, IL-10 and IL-13 cytokines, in the chronic phase of Manson's schistosomiasis. There is indication that schistosome-infected undernourished mice are able to develop a humoral immune response, but antibody titres are much lower than in the control animals. Cytokine production (IFN-gamma, IL-4, IL-10) is lower in the undernourished mice, but as infection progresses to the chronic phase its kinetics run an antagonistic course when compared to that of well-nourished animals. Marked variation in the secretion of IL-13 (a fibrogenic cytokine) could explain why undernourished mice do not develop liver "pipe-stem" fibrosis described in previous papers on well-nourished animals.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/26122/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALManson’s schistosomiasis in the undernourished.pdfManson’s schistosomiasis in the undernourished.pdfapplication/pdf1556667https://www.arca.fiocruz.br/bitstream/icict/26122/2/Manson%e2%80%99s%20schistosomiasis%20in%20the%20undernourished.pdf3887437dbe7356e646eeca70f54537faMD52TEXTManson’s schistosomiasis in the undernourished.pdf.txtManson’s schistosomiasis in the undernourished.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Manson's schistosomiasis in the undernourished mouse: some recent findings
title Manson's schistosomiasis in the undernourished mouse: some recent findings
spellingShingle Manson's schistosomiasis in the undernourished mouse: some recent findings
Coutinho, Eridan M.
Schistosoma mansoni
Desnutrição
Imunopatologia
Schistosoma mansoni
Undernutrition
Immunopathology
Animais
Anticorpos, Helmintos / imunologia
Citocinas / imunologia
Imunidade, Humoral / imunologia
Cirrose Hepática Experimental / Imunologia
Cirrose Hepática Experimental / parasitologia
Cirrose Hepática Experimental / patologia
Desnutrição / imunologia
Desnutrição / patologia
Ratos
Ratos, Knockout
Modelos Animal
Schistosoma mansoni / imunologia
Esquistossomose mansoni / imunologia
Esquistossomose mansoni / patologia
title_short Manson's schistosomiasis in the undernourished mouse: some recent findings
title_full Manson's schistosomiasis in the undernourished mouse: some recent findings
title_fullStr Manson's schistosomiasis in the undernourished mouse: some recent findings
title_full_unstemmed Manson's schistosomiasis in the undernourished mouse: some recent findings
title_sort Manson's schistosomiasis in the undernourished mouse: some recent findings
author Coutinho, Eridan M.
author_facet Coutinho, Eridan M.
Oliveira, Sheilla A. de
Barros, Andréia F. de
Silva, Fabiana L.
Ramos, Renata P.
author_role author
author2 Oliveira, Sheilla A. de
Barros, Andréia F. de
Silva, Fabiana L.
Ramos, Renata P.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Coutinho, Eridan M.
Oliveira, Sheilla A. de
Barros, Andréia F. de
Silva, Fabiana L.
Ramos, Renata P.
dc.subject.other.pt_BR.fl_str_mv Schistosoma mansoni
Desnutrição
Imunopatologia
topic Schistosoma mansoni
Desnutrição
Imunopatologia
Schistosoma mansoni
Undernutrition
Immunopathology
Animais
Anticorpos, Helmintos / imunologia
Citocinas / imunologia
Imunidade, Humoral / imunologia
Cirrose Hepática Experimental / Imunologia
Cirrose Hepática Experimental / parasitologia
Cirrose Hepática Experimental / patologia
Desnutrição / imunologia
Desnutrição / patologia
Ratos
Ratos, Knockout
Modelos Animal
Schistosoma mansoni / imunologia
Esquistossomose mansoni / imunologia
Esquistossomose mansoni / patologia
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Undernutrition
Immunopathology
dc.subject.decs.pt_BR.fl_str_mv Animais
Anticorpos, Helmintos / imunologia
Citocinas / imunologia
Imunidade, Humoral / imunologia
Cirrose Hepática Experimental / Imunologia
Cirrose Hepática Experimental / parasitologia
Cirrose Hepática Experimental / patologia
Desnutrição / imunologia
Desnutrição / patologia
Ratos
Ratos, Knockout
Modelos Animal
Schistosoma mansoni / imunologia
Esquistossomose mansoni / imunologia
Esquistossomose mansoni / patologia
description Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-04-26T12:34:37Z
dc.date.available.fl_str_mv 2018-04-26T12:34:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
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dc.identifier.citation.fl_str_mv COUTINHO, E. M. et al. Manson’s schistosomiasis in the undernourished mouse: some recent findings. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 359–366, jul. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26122
dc.identifier.issn.pt_BR.fl_str_mv 1678-8060
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762010000400002
identifier_str_mv COUTINHO, E. M. et al. Manson’s schistosomiasis in the undernourished mouse: some recent findings. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 359–366, jul. 2010.
1678-8060
10.1590/S0074-02762010000400002
url https://www.arca.fiocruz.br/handle/icict/26122
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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