Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20048 |
Resumo: | Soares, Milena Botelho Pereira. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. Marcos Veríssimo de Oliveira Cardoso a, *, Diogo Rodrigo Magalhães Moreira a, Gevanio Bezerra Oliveira Filho a, Suellen Melo Tiburcio Cavalcanti a, Lucas Cunha Duarte Coelho a, Jos e Wanderlan Pontes Espíndola a, Laura Rubio Gonzalez a, Marcelo Montenegro Rabello a, Marcelo Zaldini Hernandes a, Paulo Michel Pinheiro Ferreira b, Cl audia Pessoa c, d, Carlos Alberto de Simone e, Elisalva Teixeira Guimarães f, Milena Botelho Pereira Soares g, Ana Cristina Lima Leite a a Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil b Departamento de Biofísica e Fisiologia, Programa de P os-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, 64049-550, Teresina, PI, Brazil c Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear a, 60430-270, Fortaleza, CE, Brazil d Fundação Oswaldo Cruz, 60180-900, Fortaleza, CE, Brasil e Departamento de Física e Inform atica, Instituto de Física, Universidade de São Paulo, 13560-970, São Carlos, SP, Brazil f Departamento de Ciências da Vida, Universidade do Estado da Bahia, 41150-000, Salvador, BA, Brazil g Hospital São Rafael, 41253-190, Salvador, BA, Brazil |
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Cardoso, Marcos Veríssimo de OliveiraMoreira, Diogo Rodrigo MagalhãesOliveira Filho, Gevanio BezerraCavalcanti, Suellen Melo TiburcioCoelho, Lucas Cunha DuarteEspíndola, José Wanderlan PontesGonzalez, Laura RubioRabello, Marcelo MontenegroHernandes, Marcelo ZaldiniFerreira, Paulo Michel PinheiroPessoa, CláudiaSimone, Carlos Alberto deGuimarães, Elisalva TeixeiraSoares, Milena Botelho PereiraLeite, Ana Cristina Lima2017-07-12T13:12:17Z2017-07-12T13:12:17Z2015CARDOSO, M. V. O. et al. Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities. European Journal of Medicinal Chemistry, v. 96, p. 491e503, 2015.0223-5234https://www.arca.fiocruz.br/handle/icict/2004810.1016/j.ejmech.2015.04.041Soares, Milena Botelho Pereira. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. Marcos Veríssimo de Oliveira Cardoso a, *, Diogo Rodrigo Magalhães Moreira a, Gevanio Bezerra Oliveira Filho a, Suellen Melo Tiburcio Cavalcanti a, Lucas Cunha Duarte Coelho a, Jos e Wanderlan Pontes Espíndola a, Laura Rubio Gonzalez a, Marcelo Montenegro Rabello a, Marcelo Zaldini Hernandes a, Paulo Michel Pinheiro Ferreira b, Cl audia Pessoa c, d, Carlos Alberto de Simone e, Elisalva Teixeira Guimarães f, Milena Botelho Pereira Soares g, Ana Cristina Lima Leite a a Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil b Departamento de Biofísica e Fisiologia, Programa de P os-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, 64049-550, Teresina, PI, Brazil c Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear a, 60430-270, Fortaleza, CE, Brazil d Fundação Oswaldo Cruz, 60180-900, Fortaleza, CE, Brasil e Departamento de Física e Inform atica, Instituto de Física, Universidade de São Paulo, 13560-970, São Carlos, SP, Brazil f Departamento de Ciências da Vida, Universidade do Estado da Bahia, 41150-000, Salvador, BA, Brazil g Hospital São Rafael, 41253-190, Salvador, BA, BrazilMúltipla - ver em NotasThe present work reports the synthesis and evaluation of the antitumour and immunomodulatory properties of new phthalimides derivatives designed to explore molecular hybridization and bioisosterism approaches between thalidomide, thiosemicarbazone, thiazolidinone and thiazole series. Twenty-seven new molecules were assessed for their immunosuppressive effect toward TNFα, IFNγ, IL-2 and IL-6 production and antiproliferative activity. The best activity profile was observed for the (6a-f) series, which presents phthalyl and thiazolidinone groups.engElsevierFtalimidasThiosemicarbazoneThiazoleThiazolidinoneAntiproliferativaImunosupressoraPhthalimideThiosemicarbazoneThiazoleThiazolidinoneAntiproliferativeImmunosuppressiveDesign, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activitiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20048/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCardoso MVO Design, synthesis and structure activity.....pdfCardoso MVO Design, synthesis and structure 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| dc.title.pt_BR.fl_str_mv |
Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities |
| title |
Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities |
| spellingShingle |
Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities Cardoso, Marcos Veríssimo de Oliveira Ftalimidas Thiosemicarbazone Thiazole Thiazolidinone Antiproliferativa Imunosupressora Phthalimide Thiosemicarbazone Thiazole Thiazolidinone Antiproliferative Immunosuppressive |
| title_short |
Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities |
| title_full |
Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities |
| title_fullStr |
Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities |
| title_full_unstemmed |
Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities |
| title_sort |
Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities |
| author |
Cardoso, Marcos Veríssimo de Oliveira |
| author_facet |
Cardoso, Marcos Veríssimo de Oliveira Moreira, Diogo Rodrigo Magalhães Oliveira Filho, Gevanio Bezerra Cavalcanti, Suellen Melo Tiburcio Coelho, Lucas Cunha Duarte Espíndola, José Wanderlan Pontes Gonzalez, Laura Rubio Rabello, Marcelo Montenegro Hernandes, Marcelo Zaldini Ferreira, Paulo Michel Pinheiro Pessoa, Cláudia Simone, Carlos Alberto de Guimarães, Elisalva Teixeira Soares, Milena Botelho Pereira Leite, Ana Cristina Lima |
| author_role |
author |
| author2 |
Moreira, Diogo Rodrigo Magalhães Oliveira Filho, Gevanio Bezerra Cavalcanti, Suellen Melo Tiburcio Coelho, Lucas Cunha Duarte Espíndola, José Wanderlan Pontes Gonzalez, Laura Rubio Rabello, Marcelo Montenegro Hernandes, Marcelo Zaldini Ferreira, Paulo Michel Pinheiro Pessoa, Cláudia Simone, Carlos Alberto de Guimarães, Elisalva Teixeira Soares, Milena Botelho Pereira Leite, Ana Cristina Lima |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cardoso, Marcos Veríssimo de Oliveira Moreira, Diogo Rodrigo Magalhães Oliveira Filho, Gevanio Bezerra Cavalcanti, Suellen Melo Tiburcio Coelho, Lucas Cunha Duarte Espíndola, José Wanderlan Pontes Gonzalez, Laura Rubio Rabello, Marcelo Montenegro Hernandes, Marcelo Zaldini Ferreira, Paulo Michel Pinheiro Pessoa, Cláudia Simone, Carlos Alberto de Guimarães, Elisalva Teixeira Soares, Milena Botelho Pereira Leite, Ana Cristina Lima |
| dc.subject.other.pt_BR.fl_str_mv |
Ftalimidas Thiosemicarbazone Thiazole Thiazolidinone Antiproliferativa Imunosupressora |
| topic |
Ftalimidas Thiosemicarbazone Thiazole Thiazolidinone Antiproliferativa Imunosupressora Phthalimide Thiosemicarbazone Thiazole Thiazolidinone Antiproliferative Immunosuppressive |
| dc.subject.en.pt_BR.fl_str_mv |
Phthalimide Thiosemicarbazone Thiazole Thiazolidinone Antiproliferative Immunosuppressive |
| description |
Soares, Milena Botelho Pereira. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. Marcos Veríssimo de Oliveira Cardoso a, *, Diogo Rodrigo Magalhães Moreira a, Gevanio Bezerra Oliveira Filho a, Suellen Melo Tiburcio Cavalcanti a, Lucas Cunha Duarte Coelho a, Jos e Wanderlan Pontes Espíndola a, Laura Rubio Gonzalez a, Marcelo Montenegro Rabello a, Marcelo Zaldini Hernandes a, Paulo Michel Pinheiro Ferreira b, Cl audia Pessoa c, d, Carlos Alberto de Simone e, Elisalva Teixeira Guimarães f, Milena Botelho Pereira Soares g, Ana Cristina Lima Leite a a Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil b Departamento de Biofísica e Fisiologia, Programa de P os-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, 64049-550, Teresina, PI, Brazil c Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Cear a, 60430-270, Fortaleza, CE, Brazil d Fundação Oswaldo Cruz, 60180-900, Fortaleza, CE, Brasil e Departamento de Física e Inform atica, Instituto de Física, Universidade de São Paulo, 13560-970, São Carlos, SP, Brazil f Departamento de Ciências da Vida, Universidade do Estado da Bahia, 41150-000, Salvador, BA, Brazil g Hospital São Rafael, 41253-190, Salvador, BA, Brazil |
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2015 |
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2015 |
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CARDOSO, M. V. O. et al. Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities. European Journal of Medicinal Chemistry, v. 96, p. 491e503, 2015. |
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https://www.arca.fiocruz.br/handle/icict/20048 |
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0223-5234 |
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10.1016/j.ejmech.2015.04.041 |
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CARDOSO, M. V. O. et al. Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities. European Journal of Medicinal Chemistry, v. 96, p. 491e503, 2015. 0223-5234 10.1016/j.ejmech.2015.04.041 |
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