Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16596 |
Resumo: | Brazilian National Research Council (CNPq), Research Foundation of Pernambuco State (FACEPE) and FIOCRUZ. |
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Santos, Thiago André Ramos dosSilva, Aline Caroline daSilva, Elany BarbosaGomes, Paulo André Teixeira de MoraesEspíndola, José Wanderlan PontesCardoso, Marcos Veríssimo de OliveiraMoreira, Diogo Rodrigo MagalhãesLeite, Ana Cristina LimaPereira, Valéria R A2016-12-29T13:24:03Z2016-12-29T13:24:03Z2016SANTOS, T. A. T. et al. Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells. Biomedicine & Pharmacotherapy, v. 82, p. 555–560, 2016.0753-3322https://www.arca.fiocruz.br/handle/icict/1659610.1016/j.biopha.2016.05.038Brazilian National Research Council (CNPq), Research Foundation of Pernambuco State (FACEPE) and FIOCRUZ.Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, BrasilCancer remains a high incidence and mortality disease, causing around 8.2 million of deaths in the last year. Current chemotherapy needs to be expanded, making research for new drugs a necessary task. Immune system modulation is an emerging concept in cancer cell proliferation control. In fact, there are a number of mechanisms underlying the role immune system plays in tumor cells. In this work, we describe the structural design, synthesis, antitumor and immunomodulatory potential of 31 new 1,3-thiazole and thiosemicarbazone compounds. Cisplatin was used as anticancer drug control. Cytotoxicity against J774A.1 macrophages and antitumor activity against HT-29 and Jurkat cells was determined. These 1,3-thiazole and thiosemicarbazone compounds not only exhibited cytotoxicity in cancer cells, but were able to cause irreversible cancer cell damage by inducing necrosis and apoptosis. In addition, these compounds, especially pyridyl-thiazoles compounds, regulated immune factors such as interleukin 10 and tumor necrosis factor, possible by directing immune system in favor of modulating cancer cell proliferation. By examining their pharmacological activity, we were able to identify new potent and selective anticancer compounds.engElsevierDesenvolvimento de fármacosCancerSistema imunitário1,3-tiazolesThiosemicarbazonesMorte celularDrug developmentCancerImmune system1,3-thiazolesThiosemicarbazonesCell deathAntitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16596/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantos TAR Antitumor and immunomodulatory....pdfSantos TAR Antitumor and immunomodulatory....pdfapplication/pdf770132https://www.arca.fiocruz.br/bitstream/icict/16596/2/Santos%20TAR%20Antitumor%20and%20immunomodulatory....pdfb6d055670f9e6f1821da4d2895ab7c0dMD52TEXTSantos TAR Antitumor and immunomodulatory....pdf.txtSantos TAR Antitumor and immunomodulatory....pdf.txtExtracted texttext/plain30214https://www.arca.fiocruz.br/bitstream/icict/16596/3/Santos%20TAR%20Antitumor%20and%20immunomodulatory....pdf.txt1b9882fb32e7e78052fd83625c641232MD53icict/165962023-03-15 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| dc.title.pt_BR.fl_str_mv |
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells |
| title |
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells |
| spellingShingle |
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells Santos, Thiago André Ramos dos Desenvolvimento de fármacos Cancer Sistema imunitário 1,3-tiazoles Thiosemicarbazones Morte celular Drug development Cancer Immune system 1,3-thiazoles Thiosemicarbazones Cell death |
| title_short |
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells |
| title_full |
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells |
| title_fullStr |
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells |
| title_full_unstemmed |
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells |
| title_sort |
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells |
| author |
Santos, Thiago André Ramos dos |
| author_facet |
Santos, Thiago André Ramos dos Silva, Aline Caroline da Silva, Elany Barbosa Gomes, Paulo André Teixeira de Moraes Espíndola, José Wanderlan Pontes Cardoso, Marcos Veríssimo de Oliveira Moreira, Diogo Rodrigo Magalhães Leite, Ana Cristina Lima Pereira, Valéria R A |
| author_role |
author |
| author2 |
Silva, Aline Caroline da Silva, Elany Barbosa Gomes, Paulo André Teixeira de Moraes Espíndola, José Wanderlan Pontes Cardoso, Marcos Veríssimo de Oliveira Moreira, Diogo Rodrigo Magalhães Leite, Ana Cristina Lima Pereira, Valéria R A |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Thiago André Ramos dos Silva, Aline Caroline da Silva, Elany Barbosa Gomes, Paulo André Teixeira de Moraes Espíndola, José Wanderlan Pontes Cardoso, Marcos Veríssimo de Oliveira Moreira, Diogo Rodrigo Magalhães Leite, Ana Cristina Lima Pereira, Valéria R A |
| dc.subject.other.pt_BR.fl_str_mv |
Desenvolvimento de fármacos Cancer Sistema imunitário 1,3-tiazoles Thiosemicarbazones Morte celular |
| topic |
Desenvolvimento de fármacos Cancer Sistema imunitário 1,3-tiazoles Thiosemicarbazones Morte celular Drug development Cancer Immune system 1,3-thiazoles Thiosemicarbazones Cell death |
| dc.subject.en.pt_BR.fl_str_mv |
Drug development Cancer Immune system 1,3-thiazoles Thiosemicarbazones Cell death |
| description |
Brazilian National Research Council (CNPq), Research Foundation of Pernambuco State (FACEPE) and FIOCRUZ. |
| publishDate |
2016 |
| dc.date.accessioned.fl_str_mv |
2016-12-29T13:24:03Z |
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2016-12-29T13:24:03Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SANTOS, T. A. T. et al. Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells. Biomedicine & Pharmacotherapy, v. 82, p. 555–560, 2016. |
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https://www.arca.fiocruz.br/handle/icict/16596 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0753-3322 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.biopha.2016.05.038 |
| identifier_str_mv |
SANTOS, T. A. T. et al. Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells. Biomedicine & Pharmacotherapy, v. 82, p. 555–560, 2016. 0753-3322 10.1016/j.biopha.2016.05.038 |
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Elsevier |
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Elsevier |
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