Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32786 |
Resumo: | Paulo Filemon Paolucci Pimenta. Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brazil. |
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Pinheiro, Tauyne MenegaldoMota, Mânlio Tasso de OliveiraWatanabe, Aripuanã Sakurada AranhaBiselli-Périco, Joice MatosDrumond, Betânia PaivaRibeiro, Milene RochaVedovello, DanilaAraújo, João PessoaPimenta, Paulo Filemon PaolucciChaves, Bárbara AparecidaSilva, Mayara Marques Carneiro daBatista, Izabella Cristina AndradePapa, Michelle PremazziMeuren, Lana MonteiroLucas, Carolina Gonçalves de OliveiraMatassoli, Flavio LemosGil, Laura Helena Vega GonzalesBozzi, AdrianaCalzavara-Silva, Carlos EduardoArruda, Luciana Barros deSouza, Danielle da Glória deTeixeira, Mauro MartinsVasilakis, NikosNogueira, Maurício Lacerda2019-04-26T15:30:14Z2019-04-26T15:30:14Z2018PINHEIRO, Tauyne Menegaldo et al. Viral Immunogenicity Determines Epidemiological Fitness in a Cohort of DENV-1 Infection in Brazil. PLOS Neglected Tropical Diseases, v. 12, n. 5, p. 1-25, May 2018.1935-2735https://www.arca.fiocruz.br/handle/icict/3278610.1371/journal.pntd.0006525Paulo Filemon Paolucci Pimenta. Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brazil.Izabella Cristina Andrade Batista. Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Bárbara Aparecida Chaves. Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brazil.Adriana Bozzi. Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Carlos Eduardo Calzavara-Silva. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Mayara Marques Carneiro da Silva. Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brazil.Laura Helena Vega Gonzales Gil. Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brazil.1 Laboratório de Pesquisa em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, SP, Brazil, 2 Laboratório de Vírus, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, 3 Laboratório de Virologia, Departamento de Microbiologia e Imunologia, Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brazil, 4 Laboratório de Entomologia Médica, Centro de Pesquisas René Rachou, Fiocruz, Belo Horizonte, MG, Brazil, 5 Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas (UEA) e Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, AM, Brazil, 6 Departamento de Virologia, Centro de Pesquisas Aggeu Magalhães, Fiocruz, Recife, PE, Brazil, 7 Laboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou, Fiocruz, Belo Horizonte, MG, Brazil, 8 Laboratório de Genética e Imunologia das Infecções Virais, Departamento de Virologia, Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, RJ, Brazil, 9 Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, 10 Laboratório de Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, 11 Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Institute of Human Infections and Immunity, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, United States of America.Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP), Bolsas # 2012 / 11733-6 e 2013 / 21719-3 para o MLN e 2015 / 22750-7 para o TMP e por INCT-Dengue / CNPq. MLN e MMT são CNPq Companheiros. NV é suportado por um NIH / NIAID Grant # U01 AI115577.Múltipla - ver em Notas.The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto.engViral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAedesAnimalsB-LymphocytesBrazilCohort StudiesDengueGenotypeHumansMaleMice, Inbred C57BLPhylogenyT-LymphocytesAedes / fisiologiaAedes / virologiaAnimaisLinfócitos B / imunologiaBrasilEstudos de coorteDengue / imunologiaDengue / transmissãoDengue / virologiaVírus da Dengue / classificaçãoVírus da Dengue / genéticaVírus da Dengue / imunologiaVírus da Dengue / isolamento e purificaçãoGenótipoHumanosMasculinoRatos, endogâmicos C57BLFilogeniaLinfócitos T / imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83094https://www.arca.fiocruz.br/bitstream/icict/32786/1/license.txtee3692f7b0b97d5638099ab94397d05fMD51ORIGINALViral immunogenicity determines.pdfViral immunogenicity determines.pdfapplication/pdf7169763https://www.arca.fiocruz.br/bitstream/icict/32786/2/Viral%20immunogenicity%20determines.pdf9e3e058eb4ce42409f6c24384ab6ac3aMD52TEXTViral immunogenicity determines.pdf.txtViral immunogenicity determines.pdf.txtExtracted texttext/plain77746https://www.arca.fiocruz.br/bitstream/icict/32786/3/Viral%20immunogenicity%20determines.pdf.txt209ab544f7051fd3464ec5232e81a409MD53icict/327862019-04-28 20:14:47.802oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-04-28T23:14:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
| title |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
| spellingShingle |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil Pinheiro, Tauyne Menegaldo Aedes Animals B-Lymphocytes Brazil Cohort Studies Dengue Genotype Humans Male Mice, Inbred C57BL Phylogeny T-Lymphocytes Aedes / fisiologia Aedes / virologia Animais Linfócitos B / imunologia Brasil Estudos de coorte Dengue / imunologia Dengue / transmissão Dengue / virologia Vírus da Dengue / classificação Vírus da Dengue / genética Vírus da Dengue / imunologia Vírus da Dengue / isolamento e purificação Genótipo Humanos Masculino Ratos, endogâmicos C57BL Filogenia Linfócitos T / imunologia |
| title_short |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
| title_full |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
| title_fullStr |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
| title_full_unstemmed |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
| title_sort |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
| author |
Pinheiro, Tauyne Menegaldo |
| author_facet |
Pinheiro, Tauyne Menegaldo Mota, Mânlio Tasso de Oliveira Watanabe, Aripuanã Sakurada Aranha Biselli-Périco, Joice Matos Drumond, Betânia Paiva Ribeiro, Milene Rocha Vedovello, Danila Araújo, João Pessoa Pimenta, Paulo Filemon Paolucci Chaves, Bárbara Aparecida Silva, Mayara Marques Carneiro da Batista, Izabella Cristina Andrade Papa, Michelle Premazzi Meuren, Lana Monteiro Lucas, Carolina Gonçalves de Oliveira Matassoli, Flavio Lemos Gil, Laura Helena Vega Gonzales Bozzi, Adriana Calzavara-Silva, Carlos Eduardo Arruda, Luciana Barros de Souza, Danielle da Glória de Teixeira, Mauro Martins Vasilakis, Nikos Nogueira, Maurício Lacerda |
| author_role |
author |
| author2 |
Mota, Mânlio Tasso de Oliveira Watanabe, Aripuanã Sakurada Aranha Biselli-Périco, Joice Matos Drumond, Betânia Paiva Ribeiro, Milene Rocha Vedovello, Danila Araújo, João Pessoa Pimenta, Paulo Filemon Paolucci Chaves, Bárbara Aparecida Silva, Mayara Marques Carneiro da Batista, Izabella Cristina Andrade Papa, Michelle Premazzi Meuren, Lana Monteiro Lucas, Carolina Gonçalves de Oliveira Matassoli, Flavio Lemos Gil, Laura Helena Vega Gonzales Bozzi, Adriana Calzavara-Silva, Carlos Eduardo Arruda, Luciana Barros de Souza, Danielle da Glória de Teixeira, Mauro Martins Vasilakis, Nikos Nogueira, Maurício Lacerda |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pinheiro, Tauyne Menegaldo Mota, Mânlio Tasso de Oliveira Watanabe, Aripuanã Sakurada Aranha Biselli-Périco, Joice Matos Drumond, Betânia Paiva Ribeiro, Milene Rocha Vedovello, Danila Araújo, João Pessoa Pimenta, Paulo Filemon Paolucci Chaves, Bárbara Aparecida Silva, Mayara Marques Carneiro da Batista, Izabella Cristina Andrade Papa, Michelle Premazzi Meuren, Lana Monteiro Lucas, Carolina Gonçalves de Oliveira Matassoli, Flavio Lemos Gil, Laura Helena Vega Gonzales Bozzi, Adriana Calzavara-Silva, Carlos Eduardo Arruda, Luciana Barros de Souza, Danielle da Glória de Teixeira, Mauro Martins Vasilakis, Nikos Nogueira, Maurício Lacerda |
| dc.subject.en.pt_BR.fl_str_mv |
Aedes Animals B-Lymphocytes Brazil Cohort Studies Dengue Genotype Humans Male Mice, Inbred C57BL Phylogeny T-Lymphocytes |
| topic |
Aedes Animals B-Lymphocytes Brazil Cohort Studies Dengue Genotype Humans Male Mice, Inbred C57BL Phylogeny T-Lymphocytes Aedes / fisiologia Aedes / virologia Animais Linfócitos B / imunologia Brasil Estudos de coorte Dengue / imunologia Dengue / transmissão Dengue / virologia Vírus da Dengue / classificação Vírus da Dengue / genética Vírus da Dengue / imunologia Vírus da Dengue / isolamento e purificação Genótipo Humanos Masculino Ratos, endogâmicos C57BL Filogenia Linfócitos T / imunologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Aedes / fisiologia Aedes / virologia Animais Linfócitos B / imunologia Brasil Estudos de coorte Dengue / imunologia Dengue / transmissão Dengue / virologia Vírus da Dengue / classificação Vírus da Dengue / genética Vírus da Dengue / imunologia Vírus da Dengue / isolamento e purificação Genótipo Humanos Masculino Ratos, endogâmicos C57BL Filogenia Linfócitos T / imunologia |
| description |
Paulo Filemon Paolucci Pimenta. Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brazil. |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018 |
| dc.date.accessioned.fl_str_mv |
2019-04-26T15:30:14Z |
| dc.date.available.fl_str_mv |
2019-04-26T15:30:14Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
PINHEIRO, Tauyne Menegaldo et al. Viral Immunogenicity Determines Epidemiological Fitness in a Cohort of DENV-1 Infection in Brazil. PLOS Neglected Tropical Diseases, v. 12, n. 5, p. 1-25, May 2018. |
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https://www.arca.fiocruz.br/handle/icict/32786 |
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1935-2735 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0006525 |
| identifier_str_mv |
PINHEIRO, Tauyne Menegaldo et al. Viral Immunogenicity Determines Epidemiological Fitness in a Cohort of DENV-1 Infection in Brazil. PLOS Neglected Tropical Diseases, v. 12, n. 5, p. 1-25, May 2018. 1935-2735 10.1371/journal.pntd.0006525 |
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https://www.arca.fiocruz.br/handle/icict/32786 |
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