Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.

Detalhes bibliográficos
Autor(a) principal: Santiago, Mittermayer Barreto
Data de Publicação: 2001
Outros Autores: Martinelli, Reinaldo, Ko, Albert Icksang, Reis, Eliana Almeida Gomes, Fontes, Roberto Dias, Nascimento, Eliane Góes, Pierangeli, Silvia, Espinola, Ricardo, Gharavi, Azzudin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11946
Resumo: Fundação Baiana para o Desenvolvimento da Ciência. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Salvador, BA, Brasil
id CRUZ_b2f32e98458cbdc194636ec75e9ddb7d
oai_identifier_str oai:www.arca.fiocruz.br:icict/11946
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Santiago, Mittermayer BarretoMartinelli, ReinaldoKo, Albert IcksangReis, Eliana Almeida GomesFontes, Roberto DiasNascimento, Eliane GóesPierangeli, SilviaEspinola, RicardoGharavi, Azzudin2015-10-14T17:34:49Z2015-10-14T17:34:49Z2001SANTIAGO, M. B. et al. Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. Clinical and Experimental Rheumatology, v. 19, n. 4, p. 425-430, 2001.0392-856Xhttps://www.arca.fiocruz.br/handle/icict/11946engClinical and Experimental Rheumatology SasAnti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Baiana para o Desenvolvimento da Ciência. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Cornell University. Weill Medical College. New York, NYFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilCOAS. DST. SESAB. Salvador, Bahia, BrasilPIEJ. SESAB. Salvador, Bahia, BrasilMorehouse School of Medicine. Atlanta, Georgia, USAMorehouse School of Medicine. Atlanta, Georgia, USAMorehouse School of Medicine. Atlanta, Georgia, USAReports have shown that anticardiolipin (aCL) antibodies present in patients with autoimmune diseases are dependent on the cofactor,beta2 glycoprotein I (beta2 GPI), as opposed to aCL antibodies seen in infectious diseases such as syphilis, HIV hepatitis C, etc. The assay for anti-beta2GPI antibodies has been reported to be more specific for antiphospholipid syndrome (APS). However, the prevalence of these antibodies in diseases such as leishmaniasis and leptospirosis remains unknown. The aim of the present study was determine the prevalence of antibodies to cardiolipin and to beta2GPI in patients with different infectious diseases, including leptospirosis, syphilis and leishmaniasis. METHODS: Samples from patients with Kala-azar (visceral leishmaniasis), syphilis or leptospirosis were tested for IgG and IgM anticardiolipin and IgG anti-beta2GPI antibodies by ELISA. RESULTS: In patients with Kala-azar the prevalence of IgG aCL, IgM aCL and anti-beta2GPI was 6% (2/30), 3% (1/30) and 53% (16/30), respectively. In syphilis the prevalence was 18% (14/74), 13% (10/74) and 10% (8/70), respectively. In leptospirosis the frequency of these antibodies was 23% (9/39), 10% (4/39) and 17% (6/34), respectively. There was no statistical correlation between aCL and anti-beta2GPI antibodies in these diseases. DISCUSSION: This study clearly shows a significant prevalence of anti-beta2GPI antibodies in leptospirosis and leishmaniasis and syphilis. This indicates that the assay for antibeta2GPI antibodies should be thoroughly validated before it is introduced as a definitive tool for the diagnosis of APS, testing a larger number of sera from patients with a wider range of clinical conditions.Antiphospholipid antibodiesAnticardiolipin antibodiesAnti- 2 glycoprotein ISyphilisLeptospirosisKala-azarAnticorpos Anticardiolipina/análiseGlicoproteínas/imunologiaLeptospirose/imunologiaSífilis/imunologiaAdolescenteLeishmaniose Visceral/imunologiaIdosoCriançaPré-EscolarFemininoHumanosImunoglobulina G/sangueLactenteMasculinoMeia-Idadebeta 2-Glicoproteína IAdultoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11946/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALSantiago, M Anti-beta 2 glycoprotein I....pdfSantiago, M Anti-beta 2 glycoprotein I....pdfapplication/pdf356814https://www.arca.fiocruz.br/bitstream/icict/11946/2/Santiago%2c%20M%20Anti-beta%202%20glycoprotein%20I....pdf95b6dbbab2ab8b46eceb37019dcbe270MD52TEXTSantiago, M Anti-beta 2 glycoprotein I....pdf.txtSantiago, M Anti-beta 2 glycoprotein I....pdf.txtExtracted texttext/plain27848https://www.arca.fiocruz.br/bitstream/icict/11946/3/Santiago%2c%20M%20Anti-beta%202%20glycoprotein%20I....pdf.txt7165b43b61e50d50cfa6e2e023e4c6dcMD53icict/119462023-03-15 14:33:10.597oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
title Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
spellingShingle Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
Santiago, Mittermayer Barreto
Antiphospholipid antibodies
Anticardiolipin antibodies
Anti- 2 glycoprotein I
Syphilis
Leptospirosis
Kala-azar
Anticorpos Anticardiolipina/análise
Glicoproteínas/imunologia
Leptospirose/imunologia
Sífilis/imunologia
Adolescente
Leishmaniose Visceral/imunologia
Idoso
Criança
Pré-Escolar
Feminino
Humanos
Imunoglobulina G/sangue
Lactente
Masculino
Meia-Idade
beta 2-Glicoproteína I
Adulto
title_short Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
title_full Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
title_fullStr Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
title_full_unstemmed Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
title_sort Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar.
author Santiago, Mittermayer Barreto
author_facet Santiago, Mittermayer Barreto
Martinelli, Reinaldo
Ko, Albert Icksang
Reis, Eliana Almeida Gomes
Fontes, Roberto Dias
Nascimento, Eliane Góes
Pierangeli, Silvia
Espinola, Ricardo
Gharavi, Azzudin
author_role author
author2 Martinelli, Reinaldo
Ko, Albert Icksang
Reis, Eliana Almeida Gomes
Fontes, Roberto Dias
Nascimento, Eliane Góes
Pierangeli, Silvia
Espinola, Ricardo
Gharavi, Azzudin
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santiago, Mittermayer Barreto
Martinelli, Reinaldo
Ko, Albert Icksang
Reis, Eliana Almeida Gomes
Fontes, Roberto Dias
Nascimento, Eliane Góes
Pierangeli, Silvia
Espinola, Ricardo
Gharavi, Azzudin
dc.subject.en.pt_BR.fl_str_mv Antiphospholipid antibodies
Anticardiolipin antibodies
Anti- 2 glycoprotein I
Syphilis
Leptospirosis
Kala-azar
topic Antiphospholipid antibodies
Anticardiolipin antibodies
Anti- 2 glycoprotein I
Syphilis
Leptospirosis
Kala-azar
Anticorpos Anticardiolipina/análise
Glicoproteínas/imunologia
Leptospirose/imunologia
Sífilis/imunologia
Adolescente
Leishmaniose Visceral/imunologia
Idoso
Criança
Pré-Escolar
Feminino
Humanos
Imunoglobulina G/sangue
Lactente
Masculino
Meia-Idade
beta 2-Glicoproteína I
Adulto
dc.subject.decs.pt_BR.fl_str_mv Anticorpos Anticardiolipina/análise
Glicoproteínas/imunologia
Leptospirose/imunologia
Sífilis/imunologia
Adolescente
Leishmaniose Visceral/imunologia
Idoso
Criança
Pré-Escolar
Feminino
Humanos
Imunoglobulina G/sangue
Lactente
Masculino
Meia-Idade
beta 2-Glicoproteína I
Adulto
description Fundação Baiana para o Desenvolvimento da Ciência. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Salvador, BA, Brasil
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2015-10-14T17:34:49Z
dc.date.available.fl_str_mv 2015-10-14T17:34:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTIAGO, M. B. et al. Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. Clinical and Experimental Rheumatology, v. 19, n. 4, p. 425-430, 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11946
dc.identifier.issn.none.fl_str_mv 0392-856X
identifier_str_mv SANTIAGO, M. B. et al. Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. Clinical and Experimental Rheumatology, v. 19, n. 4, p. 425-430, 2001.
0392-856X
url https://www.arca.fiocruz.br/handle/icict/11946
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Clinical and Experimental Rheumatology Sas
publisher.none.fl_str_mv Clinical and Experimental Rheumatology Sas
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11946/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/11946/2/Santiago%2c%20M%20Anti-beta%202%20glycoprotein%20I....pdf
https://www.arca.fiocruz.br/bitstream/icict/11946/3/Santiago%2c%20M%20Anti-beta%202%20glycoprotein%20I....pdf.txt
bitstream.checksum.fl_str_mv 8b4c200b4e10021c5683c6ccaba07169
95b6dbbab2ab8b46eceb37019dcbe270
7165b43b61e50d50cfa6e2e023e4c6dc
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009185231601664

Registros relacionados