HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers

Detalhes bibliográficos
Autor(a) principal: Kay, Alan
Data de Publicação: 2014
Outros Autores: Silva, Edinete Melo da, Pedreira, Henrique, Negreiros, S, Lobato, Cirley, Braga, W, Muwonge, R, Deny, P, Reis, Mitermayer Galvão dos, Zoulim, F, Trépo, Christian, D' Oliveira Junior, Argemiro, Salcedo, Juan Miguel, Schinoni, Maria Isabel, Paraná, Raymundo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1111/jvh.12267
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8094
Resumo: Inserm. Lyon, France
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spelling Kay, AlanSilva, Edinete Melo daPedreira, HenriqueNegreiros, SLobato, CirleyBraga, WMuwonge, RDeny, PReis, Mitermayer Galvão dosZoulim, FTrépo, ChristianD' Oliveira Junior, ArgemiroSalcedo, Juan MiguelSchinoni, Maria IsabelParaná, Raymundo2014-07-29T17:24:04Z2014-07-29T17:24:04Z2014KAY, A. et al. HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers. Journal of Viral Hepatitis, p. 1-5, 2014.1352-0504https://www.arca.fiocruz.br/handle/icict/809410.1111/jvh.12267engBlackwell Scientific PublicationHBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInserm. Lyon, FranceInserm. Lyon, FranceFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilAcre State Secretariat of Health. Rio Branco, BrasilAcre State Secretariat of Health. Rio Branco, BrasilInstitute of Tropical Medicine of Amazonas. Manaus, AM, BrasilInternational Agency for Research on Cancer. IARC. World Health Organization. WHO. Lyon, FranceInserm. Lyon, FranceFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilInserm. Lyon, France / Service d’H epato-Gastroent erology. H^opital de la Croix-Rousse. Lyon, FranceInserm. Lyon, France / Service d’H epato-Gastroent erology. H^opital de la Croix-Rousse. Lyon, FranceUniversity Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, BrasilFederal University of Rondônia. Rondônia, Porto Velho, Brasil / Fundação Oswaldo Cruz. Rondônia, Porto Velho, BrasilUniversity Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / University Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, BrasilSUMMARY. HDV infection still remains a serious public health problem in Amazonia. There are few data regarding the biomolecular aspects of HBV/HDV co-infection in this region. We studied 92 patients HBsAg+/anti-HDV IgG+ followed at the Hepatitis Referral Centers of Porto Velho (RO), Rio Branco and Cruzeiro do Sul (AC), Brazil, from March 2006 to March 2007 for whom the HDV and/or the HBV genotype could be determined. The HDV genotype could be determined in 90 patients, while the HBV genotypes could be positively determined in 74. HBV subgenotype F2 is the most prevalent (40.2%), followed by the subgenotypes A1 (15.2%) and D3 (8.7%), while 16.4% were other subgenotypes or genotypes, 4.3% were discordant and 15.2% were unamplifiable. Surprisingly, HDV genotype 3 (HDV-3) was found in all of the HBV/ HDV-infected patients that could be genotyped for HDV, confirming that HDV-3 can associate with non-F HBV genotypes. However, a HDV-3 mutant was found in 29.3% of patients and was more frequently associated with non-F HBV genotypes (P < 0.001) than were nonmutant strains, suggesting that the mutation may facilitate association of HDV-3 with non-F HBV genotypes.HBV/HDV co-infectionHBV/HDV genotypesHDV genotype 3Mutant HDV genotype 3info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALKay A HBV HDV co-infection....pdfKay A HBV HDV co-infection....pdfapplication/pdf111371https://www.arca.fiocruz.br/bitstream/icict/8094/1/Kay%20A%20HBV%20HDV%20co-infection....pdfab8b6f210826246b62e4430a2297b64fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8094/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTKay A HBV HDV co-infection....pdf.txtKay A HBV HDV co-infection....pdf.txtExtracted texttext/plain16158https://www.arca.fiocruz.br/bitstream/icict/8094/3/Kay%20A%20HBV%20HDV%20co-infection....pdf.txta34a0d53bbbc1e40720723f422cea22dMD53icict/80942023-03-15 14:33:22.625oai:www.arca.fiocruz.br:icict/8094TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
title HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
spellingShingle HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
Kay, Alan
HBV/HDV co-infection
HBV/HDV genotypes
HDV genotype 3
Mutant HDV genotype 3
title_short HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
title_full HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
title_fullStr HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
title_full_unstemmed HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
title_sort HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
author Kay, Alan
author_facet Kay, Alan
Silva, Edinete Melo da
Pedreira, Henrique
Negreiros, S
Lobato, Cirley
Braga, W
Muwonge, R
Deny, P
Reis, Mitermayer Galvão dos
Zoulim, F
Trépo, Christian
D' Oliveira Junior, Argemiro
Salcedo, Juan Miguel
Schinoni, Maria Isabel
Paraná, Raymundo
author_role author
author2 Silva, Edinete Melo da
Pedreira, Henrique
Negreiros, S
Lobato, Cirley
Braga, W
Muwonge, R
Deny, P
Reis, Mitermayer Galvão dos
Zoulim, F
Trépo, Christian
D' Oliveira Junior, Argemiro
Salcedo, Juan Miguel
Schinoni, Maria Isabel
Paraná, Raymundo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kay, Alan
Silva, Edinete Melo da
Pedreira, Henrique
Negreiros, S
Lobato, Cirley
Braga, W
Muwonge, R
Deny, P
Reis, Mitermayer Galvão dos
Zoulim, F
Trépo, Christian
D' Oliveira Junior, Argemiro
Salcedo, Juan Miguel
Schinoni, Maria Isabel
Paraná, Raymundo
dc.subject.en.pt_BR.fl_str_mv HBV/HDV co-infection
HBV/HDV genotypes
HDV genotype 3
Mutant HDV genotype 3
topic HBV/HDV co-infection
HBV/HDV genotypes
HDV genotype 3
Mutant HDV genotype 3
description Inserm. Lyon, France
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-07-29T17:24:04Z
dc.date.available.fl_str_mv 2014-07-29T17:24:04Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KAY, A. et al. HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers. Journal of Viral Hepatitis, p. 1-5, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8094
dc.identifier.issn.none.fl_str_mv 1352-0504
dc.identifier.doi.none.fl_str_mv 10.1111/jvh.12267
identifier_str_mv KAY, A. et al. HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers. Journal of Viral Hepatitis, p. 1-5, 2014.
1352-0504
10.1111/jvh.12267
url https://www.arca.fiocruz.br/handle/icict/8094
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Blackwell Scientific Publication
publisher.none.fl_str_mv Blackwell Scientific Publication
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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