New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19535 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
| id |
CRUZ_b3269fe4059ff067757a583ba22d2269 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/19535 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Barreto, Ana Virgínia Matos SáAlecrim, Vinícius MartinsMedeiros, Tibério Batista deDomingues, Ana Lúcia CoutinhoLopes, Edmundo PessoaMartins, João Roberto MacielNader, Helena BoncianiDiniz, George Tadeu NunesMontenegro, Silvia Maria LucenaMorais, Clarice Neuenschwander Lins de2017-06-27T17:40:46Z2017-06-27T17:40:46Z2017BARRETO, A. V. M. S. et al. New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni. Arquivos De Gastroenterologia, v. 54, n. 1, p. 51–56, mar. 2017. DOI 10.1590/S0004-2803.2017v54n1-10.1678-4219https://www.arca.fiocruz.br/handle/icict/1953510.1590/S0004-2803.2017v54n1-10porEsquistossomose mansoniFibroseCurva ROCAdolescentAdultAgedAlkaline PhosphataseBiomarkersBlood PlateletsCytokinesFemalegamma-GlutamyltransferaseHumansHyaluronic AcidLiver CirrhosisMaleMiddle AgedPredictive Value of TestsSchistosomiasis mansoniSensitivity and SpecificitySeverity of Illness IndexTransaminasesYoung AdultAdolescenteAdultoIdosoFosfatase AlcalinaBiomarcadoresPlaquetasCitocinasFemininoHumanosÁcido HialurônicoÁcido HialurônicoMasculinoMeia-IdadeValor Preditivo dos TestesEsquistossomose mansoniSensibilidade e EspecificidadeÍndice de Gravidade de DoençaTransaminasesAdulto Jovemgama-GlutamiltransferaseNew index for the diagnosis of liver fibrosis in Schistosomiasis mansoniNovo índice biológico para o diagnóstico da fibrose hepática na Esquistossomose mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilBackground – Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. Objective – To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. Methods – Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets. Ultrasound images were used to evaluate the fibrosis using Niamey’s classification and identified 19 patients without periportal fibrosis (patterns A and B), 48 with mild to moderate fibrosis (C and D) and 49 with advanced fibrosis (E and F). Results – Using multivariate analysis, a model was created, which involved alkaline phosphatase and platelets and could separate patients with different patterns of fibrosis. This index showed a better performance in separating patients without fibrosis from with advanced periportal fibrosis. The biological index showed an area under the ROC curve of 1.000. Using values below the lowest or above the highest cut-off point, the presence or absence of advanced fibrosis could be predicted in all patients. Conclusion – The index constructed can be used to separate patients with different patterns of periportal fibrosis, specially to predict advanced fibrosis in schistosomiasis patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19535/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL28079240 2017 bar-new.oa.pdf28079240 2017 bar-new.oa.pdfapplication/pdf228659https://www.arca.fiocruz.br/bitstream/icict/19535/2/28079240%202017%20bar-new.oa.pdf02fd751cad2295b33de8c5f6031d5ccfMD52TEXT28079240 2017 bar-new.oa.pdf.txt28079240 2017 bar-new.oa.pdf.txtExtracted texttext/plain33678https://www.arca.fiocruz.br/bitstream/icict/19535/3/28079240%202017%20bar-new.oa.pdf.txt8a119b372580a139663d8a853e438768MD53icict/195352018-08-15 02:30:56.522oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-08-15T05:30:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
| dc.title.alternative.pt_BR.fl_str_mv |
Novo índice biológico para o diagnóstico da fibrose hepática na Esquistossomose mansoni |
| title |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
| spellingShingle |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni Barreto, Ana Virgínia Matos Sá Esquistossomose mansoni Fibrose Curva ROC Adolescent Adult Aged Alkaline Phosphatase Biomarkers Blood Platelets Cytokines Female gamma-Glutamyltransferase Humans Hyaluronic Acid Liver Cirrhosis Male Middle Aged Predictive Value of Tests Schistosomiasis mansoni Sensitivity and Specificity Severity of Illness Index Transaminases Young Adult Adolescente Adulto Idoso Fosfatase Alcalina Biomarcadores Plaquetas Citocinas Feminino Humanos Ácido Hialurônico Ácido Hialurônico Masculino Meia-Idade Valor Preditivo dos Testes Esquistossomose mansoni Sensibilidade e Especificidade Índice de Gravidade de Doença Transaminases Adulto Jovem gama-Glutamiltransferase |
| title_short |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
| title_full |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
| title_fullStr |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
| title_full_unstemmed |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
| title_sort |
New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni |
| author |
Barreto, Ana Virgínia Matos Sá |
| author_facet |
Barreto, Ana Virgínia Matos Sá Alecrim, Vinícius Martins Medeiros, Tibério Batista de Domingues, Ana Lúcia Coutinho Lopes, Edmundo Pessoa Martins, João Roberto Maciel Nader, Helena Bonciani Diniz, George Tadeu Nunes Montenegro, Silvia Maria Lucena Morais, Clarice Neuenschwander Lins de |
| author_role |
author |
| author2 |
Alecrim, Vinícius Martins Medeiros, Tibério Batista de Domingues, Ana Lúcia Coutinho Lopes, Edmundo Pessoa Martins, João Roberto Maciel Nader, Helena Bonciani Diniz, George Tadeu Nunes Montenegro, Silvia Maria Lucena Morais, Clarice Neuenschwander Lins de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barreto, Ana Virgínia Matos Sá Alecrim, Vinícius Martins Medeiros, Tibério Batista de Domingues, Ana Lúcia Coutinho Lopes, Edmundo Pessoa Martins, João Roberto Maciel Nader, Helena Bonciani Diniz, George Tadeu Nunes Montenegro, Silvia Maria Lucena Morais, Clarice Neuenschwander Lins de |
| dc.subject.other.pt_BR.fl_str_mv |
Esquistossomose mansoni Fibrose Curva ROC |
| topic |
Esquistossomose mansoni Fibrose Curva ROC Adolescent Adult Aged Alkaline Phosphatase Biomarkers Blood Platelets Cytokines Female gamma-Glutamyltransferase Humans Hyaluronic Acid Liver Cirrhosis Male Middle Aged Predictive Value of Tests Schistosomiasis mansoni Sensitivity and Specificity Severity of Illness Index Transaminases Young Adult Adolescente Adulto Idoso Fosfatase Alcalina Biomarcadores Plaquetas Citocinas Feminino Humanos Ácido Hialurônico Ácido Hialurônico Masculino Meia-Idade Valor Preditivo dos Testes Esquistossomose mansoni Sensibilidade e Especificidade Índice de Gravidade de Doença Transaminases Adulto Jovem gama-Glutamiltransferase |
| dc.subject.en.pt_BR.fl_str_mv |
Adolescent Adult Aged Alkaline Phosphatase Biomarkers Blood Platelets Cytokines Female gamma-Glutamyltransferase Humans Hyaluronic Acid Liver Cirrhosis Male Middle Aged Predictive Value of Tests Schistosomiasis mansoni Sensitivity and Specificity Severity of Illness Index Transaminases Young Adult |
| dc.subject.decs.pt_BR.fl_str_mv |
Adolescente Adulto Idoso Fosfatase Alcalina Biomarcadores Plaquetas Citocinas Feminino Humanos Ácido Hialurônico Ácido Hialurônico Masculino Meia-Idade Valor Preditivo dos Testes Esquistossomose mansoni Sensibilidade e Especificidade Índice de Gravidade de Doença Transaminases Adulto Jovem gama-Glutamiltransferase |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
| publishDate |
2017 |
| dc.date.accessioned.fl_str_mv |
2017-06-27T17:40:46Z |
| dc.date.available.fl_str_mv |
2017-06-27T17:40:46Z |
| dc.date.issued.fl_str_mv |
2017 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
BARRETO, A. V. M. S. et al. New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni. Arquivos De Gastroenterologia, v. 54, n. 1, p. 51–56, mar. 2017. DOI 10.1590/S0004-2803.2017v54n1-10. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/19535 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1678-4219 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0004-2803.2017v54n1-10 |
| identifier_str_mv |
BARRETO, A. V. M. S. et al. New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni. Arquivos De Gastroenterologia, v. 54, n. 1, p. 51–56, mar. 2017. DOI 10.1590/S0004-2803.2017v54n1-10. 1678-4219 10.1590/S0004-2803.2017v54n1-10 |
| url |
https://www.arca.fiocruz.br/handle/icict/19535 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/19535/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/19535/2/28079240%202017%20bar-new.oa.pdf https://www.arca.fiocruz.br/bitstream/icict/19535/3/28079240%202017%20bar-new.oa.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 02fd751cad2295b33de8c5f6031d5ccf 8a119b372580a139663d8a853e438768 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324940827525120 |