Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45971 |
Resumo: | Milena Botelho Pereira Soares; Ricardo Ribeiro dos Santos; Carine Machado Azevedo Cardoso; Luciana Souza de Aragão França; Vinícius Pinto Costa Rocha. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. |
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Duarte, Cristiane AngélicoGoulart, Luiz RicardoFilice, Letícia de Souza CastroLima, Isabela Lemos deFernández, Esther CamposDantas, Noelio OliveiraSilva, Anielle Christine AlmeidaSoares, Milena Botelho PereiraSantos, Ricardo Ribeiro dosCardoso, Carine Machado AzevedoFrança, Luciana Souza de AragãoRocha, Vinícius Pinto CostaRibeiro, Ana Rosa Lopes PereiraPerez, GeronimoCarvalho, Loyna NobileGoulart, Vivian Alonso2021-02-05T11:45:39Z2021-02-05T11:45:39Z2020DUARTE, Cristiane Angélico et al. Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells. Materials, v. 13, p. 1-16, 2020.1996-1944https://www.arca.fiocruz.br/handle/icict/4597110.3390/ma13184071Milena Botelho Pereira Soares; Ricardo Ribeiro dos Santos; Carine Machado Azevedo Cardoso; Luciana Souza de Aragão França; Vinícius Pinto Costa Rocha. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.1Laboratory of Nanobiotechnology, Institute of Biotechnology (IBTEC), Federal University of Uberlandia, Uberlandia 38.400-000, Brazil; cris.angelico@terra.com.br (C.A.D.); goulartlr@gmail.com (L.R.G.); leticiafilice@ufu.br (L.d.S.C.F.); isabela.lemos@hotmail.com (I.L.d.L.); esther.fernandez@ufu.br (E.C.-F.); loyna.nobile@gmail.com (L.N.C.) 2 Laboratory of New Nanostructured and Functional Materials, Physics Institute, Federal University of Alagoas, Maceió 57073-704, Brazil; noelio@fis.ufal.br (N.O.D.); aniellechristineas@gmail.com (A.C.A.S.) 3 Laboratory of Tissue Engineering and Immunopharmacology (LETI), Oswaldo Cruz Fundation, Salvador 40.000-001, Brazil; milenabpsoares@gmail.com (M.B.P.S.); ricardoribeiro1941@gmail.com (R.R.d.S.); cariazevedo@hotmail.com (C.M.A.C.); luaragao@gmail.com (L.S.d.A.F.); vinyrocha@hotmail.com (V.P.C.R.) 4 Center of Biotechnology and Cell Therapy (CBTC), Sao Rafael Hospital, Salvador 40.000-001, Brazil 5 National Institute of Metrology, Quality and Technology (INMETRO), Institute of Biomedical Engineering, Rio de Janeiro 20.000-000, Brazil; analopes0781@gmail.com 6 Brazilian Branch of Institute of Biomaterials, Tribocorrosion and Nanomedicine (IBTN), Rio de Janeiro 20.000-000, Brazil 7 Division of Metrology of Materials, National Institute of Metrology, Quality and Technology (INMETRO), Rio de Janeiro 20.000-000, Brazil; perezgeronimo@hotmail.com 8 Laboratory of Nanotechnology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 20.000-000, Brazil * Correspondence: alonso.goulart@ufu.br; Tel.: +55-34-3235-8440 † Current Institution: Biomaterials, Biodegradables and Biomimetics Research Institute (I3Bs), University of Minho, 4800-058 Guimarães, Portugal.CNPq, CAPES, and FAPEMIG which provided financial support to the National Institute of Science and Technology in Theranostics and Nanobiotechnology (grant number APQ-03613-17).Múltipla - Ver em Notas.Titanium dioxide (TiO2) is manufactured worldwide as crystalline and amorphous forms for multiple applications, including tissue engineering, but our study proposes analyzing the impact of crystalline phases of TiO2 on Mesenchymal Stem Cells (MSCs). Several studies have already described the regenerative potential of MSCs and TiO2 has been used for bone regeneration. In this study, polydispersity index and sizes of TiO2 nanocrystals (NCs) were determined. Adipose tissue-derived Mesenchymal Stem Cells (AT-MSCs) were isolated and characterized in order to evaluate cellular viability and the internalization of nanocrystals (NCs). All of the assays were performed using the TiO2 NCs with 100% anatase (A), 91.6% anatase/9.4% rutile (AR), 64.6% rutile/35.4% anatase (RA), and 84.0% rutile/16% brookite (RB), submitted to several concentrations in 24-h treatments. Cellular localization of TiO2 NCs in the AT-MSCs was resolved by europium-doped NCs. Viability was significantly improved under the predominance of the rutile phase in NCs with localization restricted at the cytoplasm, suggesting that AR and RA NCs are not genotoxic and can be associated with most cellular activities and metabolic pathways, including glycolysis and cell division.engMDPINanocristalFase cristalinaCélula-tronco mesenquimais do tecido adiposoTiO2 nanocrystalCrystalline phaseAdipose tissue stem cellCharacterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/45971/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALDUARTE et al Characterization of 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| dc.title.pt_BR.fl_str_mv |
Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells |
| title |
Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells |
| spellingShingle |
Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells Duarte, Cristiane Angélico Nanocristal Fase cristalina Célula-tronco mesenquimais do tecido adiposo TiO2 nanocrystal Crystalline phase Adipose tissue stem cell |
| title_short |
Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells |
| title_full |
Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells |
| title_fullStr |
Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells |
| title_full_unstemmed |
Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells |
| title_sort |
Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells |
| author |
Duarte, Cristiane Angélico |
| author_facet |
Duarte, Cristiane Angélico Goulart, Luiz Ricardo Filice, Letícia de Souza Castro Lima, Isabela Lemos de Fernández, Esther Campos Dantas, Noelio Oliveira Silva, Anielle Christine Almeida Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos Cardoso, Carine Machado Azevedo França, Luciana Souza de Aragão Rocha, Vinícius Pinto Costa Ribeiro, Ana Rosa Lopes Pereira Perez, Geronimo Carvalho, Loyna Nobile Goulart, Vivian Alonso |
| author_role |
author |
| author2 |
Goulart, Luiz Ricardo Filice, Letícia de Souza Castro Lima, Isabela Lemos de Fernández, Esther Campos Dantas, Noelio Oliveira Silva, Anielle Christine Almeida Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos Cardoso, Carine Machado Azevedo França, Luciana Souza de Aragão Rocha, Vinícius Pinto Costa Ribeiro, Ana Rosa Lopes Pereira Perez, Geronimo Carvalho, Loyna Nobile Goulart, Vivian Alonso |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Duarte, Cristiane Angélico Goulart, Luiz Ricardo Filice, Letícia de Souza Castro Lima, Isabela Lemos de Fernández, Esther Campos Dantas, Noelio Oliveira Silva, Anielle Christine Almeida Soares, Milena Botelho Pereira Santos, Ricardo Ribeiro dos Cardoso, Carine Machado Azevedo França, Luciana Souza de Aragão Rocha, Vinícius Pinto Costa Ribeiro, Ana Rosa Lopes Pereira Perez, Geronimo Carvalho, Loyna Nobile Goulart, Vivian Alonso |
| dc.subject.other.pt_BR.fl_str_mv |
Nanocristal Fase cristalina Célula-tronco mesenquimais do tecido adiposo |
| topic |
Nanocristal Fase cristalina Célula-tronco mesenquimais do tecido adiposo TiO2 nanocrystal Crystalline phase Adipose tissue stem cell |
| dc.subject.en.pt_BR.fl_str_mv |
TiO2 nanocrystal Crystalline phase Adipose tissue stem cell |
| description |
Milena Botelho Pereira Soares; Ricardo Ribeiro dos Santos; Carine Machado Azevedo Cardoso; Luciana Souza de Aragão França; Vinícius Pinto Costa Rocha. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. |
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2020 |
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2020 |
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2021-02-05T11:45:39Z |
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2021-02-05T11:45:39Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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DUARTE, Cristiane Angélico et al. Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells. Materials, v. 13, p. 1-16, 2020. |
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https://www.arca.fiocruz.br/handle/icict/45971 |
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1996-1944 |
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10.3390/ma13184071 |
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DUARTE, Cristiane Angélico et al. Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells. Materials, v. 13, p. 1-16, 2020. 1996-1944 10.3390/ma13184071 |
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