The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2

Foo, Suan-Sin; Cambou, Mary Catherine; Mok, Thalia; Fajardo, Viviana M.; Jung, Kyle L.; Fuller, Trevon; Chen, Weiqiang; Kerin, Tara; Mei, Jenny; Bhattacharya, Debika; Choi, Younho; Wu, Xin; Xia, Tian; Shin, Woo-Jin; Cranston, Jessica; Aldrovandi, Grace; Tobin, Nicole; Contreras, Deisy; Ibarrondo, Francisco J.; Yang, Otto; Yang, Shangxin; Garner, Omai; Cortado, Ruth; Bryson, Yvonne; Janzen, Carla; Ghosh, Shubhamoy; Devaskar, Sherin; Asilnejad, Brenda; Moreira, Maria Elisabeth; Vasconcelos, Zilton Farias Meira de; Soni, Priya R.; Gibson, L. Caroline; Brasil, Patricia; Comhair, Suzy A. A.; Arumugaswami, Vaithilingaraja; Erzurum, Serpil C.; Rao, Rashmi; Jung, Jae U.; Nielsen-Saines, Karin

The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2

Detalhes bibliográficos
Autor(a) principal:	Foo, Suan-Sin
Data de Publicação:	2021
Outros Autores:	Cambou, Mary Catherine, Mok, Thalia, Fajardo, Viviana M., Jung, Kyle L., Fuller, Trevon, Chen, Weiqiang, Kerin, Tara, Mei, Jenny, Bhattacharya, Debika, Choi, Younho, Wu, Xin, Xia, Tian, Shin, Woo-Jin, Cranston, Jessica, Aldrovandi, Grace, Tobin, Nicole, Contreras, Deisy, Ibarrondo, Francisco J., Yang, Otto, Yang, Shangxin, Garner, Omai, Cortado, Ruth, Bryson, Yvonne, Janzen, Carla, Ghosh, Shubhamoy, Devaskar, Sherin, Asilnejad, Brenda, Moreira, Maria Elisabeth, Vasconcelos, Zilton Farias Meira de, Soni, Priya R., Gibson, L. Caroline, Brasil, Patricia, Comhair, Suzy A. A., Arumugaswami, Vaithilingaraja, Erzurum, Serpil C., Rao, Rashmi, Jung, Jae U., Nielsen-Saines, Karin
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/50451
Resumo:	Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.

Metadados do item

id	CRUZ_b5754553ec9ded71aa05cbd94fecefe4
oai_identifier_str	oai:www.arca.fiocruz.br:icict/50451
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Foo, Suan-SinCambou, Mary CatherineMok, ThaliaFajardo, Viviana M.Jung, Kyle L.Fuller, TrevonChen, WeiqiangKerin, TaraMei, JennyBhattacharya, DebikaChoi, YounhoWu, XinXia, TianShin, Woo-JinCranston, JessicaAldrovandi, GraceTobin, NicoleContreras, DeisyIbarrondo, Francisco J.Yang, OttoYang, ShangxinGarner, OmaiCortado, RuthBryson, YvonneJanzen, CarlaGhosh, ShubhamoyDevaskar, SherinAsilnejad, BrendaMoreira, Maria ElisabethVasconcelos, Zilton Farias Meira deSoni, Priya R.Gibson, L. CarolineBrasil, PatriciaComhair, Suzy A. A.Arumugaswami, VaithilingarajaErzurum, Serpil C.Rao, RashmiJung, Jae U.Nielsen-Saines, Karin2021-12-15T16:43:09Z2021-12-15T16:43:09Z2021FOO, Suan-Sin et al. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell reports medicine, v. 2, n. 11, p. 1-25, 2021https://www.arca.fiocruz.br/handle/icict/5045110.1016/j.xcrm.2021.100453engElsevierThe systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA.Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA.Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Department of Pathology and Laboratory Medicine. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Department of Pathology and Laboratory Medicine. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA.University of California. David Geffen School of Medicine. Division of Neonatology. Department of Pediatrics. Los Angeles, CA, USA.Georgetown University. School of Medicine. Washington, DC, USA.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Cedars-Sinai Medical Center. Department of Pediatrics. Los Angeles, CA, USA.Cedars-Sinai Medical Center. Department of Pediatrics. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Cleveland Clinic. Lerner Research Institute. Respiratory Institute. Cleveland, OH, USA.University of California. David Geffen School of Medicine. Department of Molecular and Medical Pharmacology. Los Angeles, CA, USA.Cleveland Clinic. Lerner Research Institute. Respiratory Institute. Cleveland, OH, USA.University of California. David Geffen School of Medicine. Division of Maternal-Fetal Medicine. Department of Obstetrics and Gynecology. Los Angeles, CA, USA.Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.University of California. David Geffen School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Los Angeles, CA, USA.While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and ESM1 and reducing BGN and CD209. Finally, COVID-19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3, and CCL21), while some undergo IL-1β/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID-19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks.COVID-19Exposed infantsIFN-λ signalingMother-infant pairsPregnancyPrenatal SARS-CoV-2 infectionSerum proteomicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50451/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALThe systemic_Trevon_Fuller_etal_INI_2021_COVID-19.pdfThe systemic_Trevon_Fuller_etal_INI_2021_COVID-19.pdfapplication/pdf6633076https://www.arca.fiocruz.br/bitstream/icict/50451/2/The%20systemic_Trevon_Fuller_etal_INI_2021_COVID-19.pdf3cf11da8e79b2b722f43c8d6f107179fMD52icict/504512022-07-09 23:55:16.907oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv	The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
title	The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
spellingShingle	The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 Foo, Suan-Sin COVID-19 Exposed infants IFN-λ signaling Mother-infant pairs Pregnancy Prenatal SARS-CoV-2 infection Serum proteomics
title_short	The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
title_full	The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
title_fullStr	The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
title_full_unstemmed	The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
title_sort	The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
author	Foo, Suan-Sin
author_facet	Foo, Suan-Sin Cambou, Mary Catherine Mok, Thalia Fajardo, Viviana M. Jung, Kyle L. Fuller, Trevon Chen, Weiqiang Kerin, Tara Mei, Jenny Bhattacharya, Debika Choi, Younho Wu, Xin Xia, Tian Shin, Woo-Jin Cranston, Jessica Aldrovandi, Grace Tobin, Nicole Contreras, Deisy Ibarrondo, Francisco J. Yang, Otto Yang, Shangxin Garner, Omai Cortado, Ruth Bryson, Yvonne Janzen, Carla Ghosh, Shubhamoy Devaskar, Sherin Asilnejad, Brenda Moreira, Maria Elisabeth Vasconcelos, Zilton Farias Meira de Soni, Priya R. Gibson, L. Caroline Brasil, Patricia Comhair, Suzy A. A. Arumugaswami, Vaithilingaraja Erzurum, Serpil C. Rao, Rashmi Jung, Jae U. Nielsen-Saines, Karin
author_role	author
author2	Cambou, Mary Catherine Mok, Thalia Fajardo, Viviana M. Jung, Kyle L. Fuller, Trevon Chen, Weiqiang Kerin, Tara Mei, Jenny Bhattacharya, Debika Choi, Younho Wu, Xin Xia, Tian Shin, Woo-Jin Cranston, Jessica Aldrovandi, Grace Tobin, Nicole Contreras, Deisy Ibarrondo, Francisco J. Yang, Otto Yang, Shangxin Garner, Omai Cortado, Ruth Bryson, Yvonne Janzen, Carla Ghosh, Shubhamoy Devaskar, Sherin Asilnejad, Brenda Moreira, Maria Elisabeth Vasconcelos, Zilton Farias Meira de Soni, Priya R. Gibson, L. Caroline Brasil, Patricia Comhair, Suzy A. A. Arumugaswami, Vaithilingaraja Erzurum, Serpil C. Rao, Rashmi Jung, Jae U. Nielsen-Saines, Karin
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Foo, Suan-Sin Cambou, Mary Catherine Mok, Thalia Fajardo, Viviana M. Jung, Kyle L. Fuller, Trevon Chen, Weiqiang Kerin, Tara Mei, Jenny Bhattacharya, Debika Choi, Younho Wu, Xin Xia, Tian Shin, Woo-Jin Cranston, Jessica Aldrovandi, Grace Tobin, Nicole Contreras, Deisy Ibarrondo, Francisco J. Yang, Otto Yang, Shangxin Garner, Omai Cortado, Ruth Bryson, Yvonne Janzen, Carla Ghosh, Shubhamoy Devaskar, Sherin Asilnejad, Brenda Moreira, Maria Elisabeth Vasconcelos, Zilton Farias Meira de Soni, Priya R. Gibson, L. Caroline Brasil, Patricia Comhair, Suzy A. A. Arumugaswami, Vaithilingaraja Erzurum, Serpil C. Rao, Rashmi Jung, Jae U. Nielsen-Saines, Karin
dc.subject.en.pt_BR.fl_str_mv	COVID-19 Exposed infants IFN-λ signaling Mother-infant pairs Pregnancy Prenatal SARS-CoV-2 infection Serum proteomics
topic	COVID-19 Exposed infants IFN-λ signaling Mother-infant pairs Pregnancy Prenatal SARS-CoV-2 infection Serum proteomics
description	Infection Biology Program. Department of Cancer Biology. Cleveland, OH, USA / Cleveland Clinic. Lerner Research Institute. Global Center for Pathogen Research and Human Health. Cleveland, OH, USA.
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-12-15T16:43:09Z
dc.date.available.fl_str_mv	2021-12-15T16:43:09Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	FOO, Suan-Sin et al. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell reports medicine, v. 2, n. 11, p. 1-25, 2021
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/50451
dc.identifier.doi.none.fl_str_mv	10.1016/j.xcrm.2021.100453
identifier_str_mv	FOO, Suan-Sin et al. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell reports medicine, v. 2, n. 11, p. 1-25, 2021 10.1016/j.xcrm.2021.100453
url	https://www.arca.fiocruz.br/handle/icict/50451
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/50451/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/50451/2/The%20systemic_Trevon_Fuller_etal_INI_2021_COVID-19.pdf
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2

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