Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area

Cogliati, Massimo; Desnos-Ollivier, Marie; McCormick-Smith, Ilka; Rickerts, Volker; Ferreira-Paim, Kennio; Meyer, Wieland; Boekhout, Teun; Hagen, Ferry; Theelen, Bart; Inácio, Joäo; Alonso, Beatriz; Colom, Maria F.; Trilles, Luciana; Montagna, Maria Teresa; De Donno, Antonella; Susever, Serdar; Ergin, Cagri; Velegraki, Aristea; Ellabib, Mohamed S.; Nardoni, Simona; Macci, Cristina; Trovato, Laura; Dipineto, Ludovico; Akcaglar, Sevim; Mlinaric-Missoni, Emilija; Bertout, Sebastien; Vencá, Ana C. F.; Sampaio, Ana C.; Criseo, Giuseppe; Ranque, Stéphane; Çerikçioğlu, Nilgün; Marchese, Anna; Vezzulli, Luigi; Ilkit, Macit; Pasquale, Vincenzo; Polacheck, Itzhack; Lockhart, Shawn R.

Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area

Detalhes bibliográficos
Autor(a) principal:	Cogliati, Massimo
Data de Publicação:	2019
Outros Autores:	Desnos-Ollivier, Marie, McCormick-Smith, Ilka, Rickerts, Volker, Ferreira-Paim, Kennio, Meyer, Wieland, Boekhout, Teun, Hagen, Ferry, Theelen, Bart, Inácio, Joäo, Alonso, Beatriz, Colom, Maria F., Trilles, Luciana, Montagna, Maria Teresa, De Donno, Antonella, Susever, Serdar, Ergin, Cagri, Velegraki, Aristea, Ellabib, Mohamed S., Nardoni, Simona, Macci, Cristina, Trovato, Laura, Dipineto, Ludovico, Akcaglar, Sevim, Mlinaric-Missoni, Emilija, Bertout, Sebastien, Vencá, Ana C. F., Sampaio, Ana C., Criseo, Giuseppe, Ranque, Stéphane, Çerikçioğlu, Nilgün, Marchese, Anna, Vezzulli, Luigi, Ilkit, Macit, Pasquale, Vincenzo, Polacheck, Itzhack, Lockhart, Shawn R.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/32981
Resumo:	Luciana Trilles. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.

Metadados do item

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spelling	Cogliati, MassimoDesnos-Ollivier, MarieMcCormick-Smith, IlkaRickerts, VolkerFerreira-Paim, KennioMeyer, WielandBoekhout, TeunHagen, FerryTheelen, BartInácio, JoäoAlonso, BeatrizColom, Maria F.Trilles, LucianaMontagna, Maria TeresaDe Donno, AntonellaSusever, SerdarErgin, CagriVelegraki, AristeaEllabib, Mohamed S.Nardoni, SimonaMacci, CristinaTrovato, LauraDipineto, LudovicoAkcaglar, SevimMlinaric-Missoni, EmilijaBertout, SebastienVencá, Ana C. F.Sampaio, Ana C.Criseo, GiuseppeRanque, StéphaneÇerikçioğlu, NilgünMarchese, AnnaVezzulli, LuigiIlkit, MacitPasquale, VincenzoPolacheck, ItzhackLockhart, Shawn R.2019-05-07T14:04:11Z2019-05-07T14:04:11Z2019COGLIATI, Massimo et al. Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area. Fungal Genetics and Biology, v. 129, p. 16-29, 2019.1087-1845https://www.arca.fiocruz.br/handle/icict/3298110.1016/j.fgb.2019.04.001Luciana Trilles. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.a Dip. Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy; b Institut Pasteur, Molecular Mycology Unit, National Reference Center for Invasive Mycoses & Antifungal, CNRS UMR2000, Paris, France; c Robert-Koch Institute, Berlin, Germany; d Molecular Mycology Research Laboratory, Center for Infectious Diseases, Faculty of Medicine and Health, Sydney Medical School, Westmead Clinical School, Marie Bashier Institute for Emerging Infectious Diseases and Biosecurity, University of Sydney, Westmead Hospital, (Research and Educational Network) Westmead Institute for Medical Research, Westmead, NSW, Australia; e Department of Microbiology, Federal University of Triangulo Mineiro, Uberaba, Minas Gerais, Brazil; f Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands; g Institute of Biodiversity and Ecosystem Dynamic (IBED), University of Amsterdam, Amsterdam, the Netherlands; h School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK; i Instituto de Investigación Sanitaria Gregorio Marañón (IisGM), Hospital Gegorio Marañón, Madrid, Spain; j Universidad Miguel Hernández, Alicante, Spain; k FIOCRUZ, Fundaçao Oswaldo Cruz, Rio de Janeiro, Brazil; l Università degli Studi di Bari “Aldo Moro”, Bari, Italy; m DiSTeBA, Università del Salento, Lecce, Italy; n Cyprus Near East University, Nicosia, Cyprus; o Pamukkale University, Denizli, Turkey; p Medical School, National and Kapodistrian University of Athens, Athens, Greece; q Medical College University of Tripoli, Tripoli, Libya; r Università di Pisa, Pisa, Italy; s National Research Council, Research Institute on Terrestrial Ecosystems (IRET), Pisa, Italy; t Università degli Studi di Catania, Catania, Italy; u University of Napoli Federico II, Napoli, Italy; v Uludag University, School of Medicine, Bursa, Turkey; w Croatian National Institute of Public Health, Zagreb, Croatia; x Unité Mixte Internationale “Recherches Translationnelles sur l'infection à VIH et les Maladies Infectieuses”, Université de Montpellier, Montpellier, France; y Instituto de Higiene e Medicina Tropical, Lisbon, Portugal; z Universidade de Trás-os-Montes e Alto Douro, CITAB, Quinta dos Prados, Vila Real, Portugal; aa Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; ab Aix-Marseille University, IRD, APHM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France; ac Marmara University, School of Medicine, Istanbul, Turkey; ad Sezione di Microbiologia del DISC, Università di Genova-IRCCS Policlinico San Martino Genova, Genova, Italy; ae Dipartimento di Scienze della Terra, dell'Ambiente e della Vita (DISTAV), Università di Genova, Genova, Italy; af University of Çukurova Sarıçam, Adana, Turkey; ag Università degli Studi di Napoli Parthenope, Napoli, Italy; ah Hadassah-Hebrew University Medical Center, Jerusalem, Israel ai; Centers for Disease Control and Prevention, Atlanta, USA.2020-05-07Múltipla - Ver em Notas.A total of 476 European isolates (310 Cryptococcus neoformans var. grubii, 150 C. neoformans var. neoformans, and 16 C. gattii species complex) from both clinical and environmental sources were analyzed by multi-locus sequence typing. Phylogenetic and population genetic analyses were performed. Sequence analysis identified 74 sequence types among C. neoformans var. neoformans (VNIV), 65 among C. neoformans var. grubii (56 VNI, 8 VNII, 1 VNB), and 5 among the C. gattii species complex (4 VGI and 1 VGIV) isolates. ST23 was the most frequent genotype (22%) among VNI isolates which were mostly grouped in a large clonal cluster including 50% of isolates. Among VNIV isolates, a predominant genotype was not identified. A high percentage of autochthonous STs were identified in both VNI (71%) and VNIV (96%) group of isolates. The 16 European C. gattii species complex isolates analyzed in the present study originated all from the environment and all belonged to a large cluster endemic in the Mediterranean area. Population genetic analysis confirmed that VNI group of isolates were characterized by low variability and clonal expansion while VNIV by a higher variability and a number of recombination events. However, when VNI and VNIV environmental isolates were compared, they showed a similar population structure with a high percentage of shared mutations and the absence of fixed mutations. Also linkage disequilibrium analysis reveals differences between clinical and environmental isolates showing a key role of PLB1 allele combinations in host infection as well as the key role of LAC1 allele combinations for survival of the fungus in the environment. The present study shows that genetic comparison of clinical and environmental isolates represents a first step to understand the genetic characteristics that cause the shift of some genotypes from a saprophytic to a parasitic life style.engElsevierGenotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean areainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCryptococcus neoformansCryptococcus gattiiMLSTPopulation geneticsEuropeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area
title	Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area
spellingShingle	Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area Cogliati, Massimo Cryptococcus neoformans Cryptococcus gattii MLST Population genetics Europe
title_short	Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area
title_full	Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area
title_fullStr	Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area
title_full_unstemmed	Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area
title_sort	Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area
author	Cogliati, Massimo
author_facet	Cogliati, Massimo Desnos-Ollivier, Marie McCormick-Smith, Ilka Rickerts, Volker Ferreira-Paim, Kennio Meyer, Wieland Boekhout, Teun Hagen, Ferry Theelen, Bart Inácio, Joäo Alonso, Beatriz Colom, Maria F. Trilles, Luciana Montagna, Maria Teresa De Donno, Antonella Susever, Serdar Ergin, Cagri Velegraki, Aristea Ellabib, Mohamed S. Nardoni, Simona Macci, Cristina Trovato, Laura Dipineto, Ludovico Akcaglar, Sevim Mlinaric-Missoni, Emilija Bertout, Sebastien Vencá, Ana C. F. Sampaio, Ana C. Criseo, Giuseppe Ranque, Stéphane Çerikçioğlu, Nilgün Marchese, Anna Vezzulli, Luigi Ilkit, Macit Pasquale, Vincenzo Polacheck, Itzhack Lockhart, Shawn R.
author_role	author
author2	Desnos-Ollivier, Marie McCormick-Smith, Ilka Rickerts, Volker Ferreira-Paim, Kennio Meyer, Wieland Boekhout, Teun Hagen, Ferry Theelen, Bart Inácio, Joäo Alonso, Beatriz Colom, Maria F. Trilles, Luciana Montagna, Maria Teresa De Donno, Antonella Susever, Serdar Ergin, Cagri Velegraki, Aristea Ellabib, Mohamed S. Nardoni, Simona Macci, Cristina Trovato, Laura Dipineto, Ludovico Akcaglar, Sevim Mlinaric-Missoni, Emilija Bertout, Sebastien Vencá, Ana C. F. Sampaio, Ana C. Criseo, Giuseppe Ranque, Stéphane Çerikçioğlu, Nilgün Marchese, Anna Vezzulli, Luigi Ilkit, Macit Pasquale, Vincenzo Polacheck, Itzhack Lockhart, Shawn R.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Cogliati, Massimo Desnos-Ollivier, Marie McCormick-Smith, Ilka Rickerts, Volker Ferreira-Paim, Kennio Meyer, Wieland Boekhout, Teun Hagen, Ferry Theelen, Bart Inácio, Joäo Alonso, Beatriz Colom, Maria F. Trilles, Luciana Montagna, Maria Teresa De Donno, Antonella Susever, Serdar Ergin, Cagri Velegraki, Aristea Ellabib, Mohamed S. Nardoni, Simona Macci, Cristina Trovato, Laura Dipineto, Ludovico Akcaglar, Sevim Mlinaric-Missoni, Emilija Bertout, Sebastien Vencá, Ana C. F. Sampaio, Ana C. Criseo, Giuseppe Ranque, Stéphane Çerikçioğlu, Nilgün Marchese, Anna Vezzulli, Luigi Ilkit, Macit Pasquale, Vincenzo Polacheck, Itzhack Lockhart, Shawn R.
dc.subject.en.pt_BR.fl_str_mv	Cryptococcus neoformans Cryptococcus gattii MLST Population genetics Europe
topic	Cryptococcus neoformans Cryptococcus gattii MLST Population genetics Europe
description	Luciana Trilles. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate	2019
dc.date.accessioned.fl_str_mv	2019-05-07T14:04:11Z
dc.date.available.fl_str_mv	2019-05-07T14:04:11Z
dc.date.issued.fl_str_mv	2019
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	COGLIATI, Massimo et al. Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area. Fungal Genetics and Biology, v. 129, p. 16-29, 2019.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/32981
dc.identifier.issn.pt_BR.fl_str_mv	1087-1845
dc.identifier.doi.none.fl_str_mv	10.1016/j.fgb.2019.04.001
identifier_str_mv	COGLIATI, Massimo et al. Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area. Fungal Genetics and Biology, v. 129, p. 16-29, 2019. 1087-1845 10.1016/j.fgb.2019.04.001
url	https://www.arca.fiocruz.br/handle/icict/32981
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
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reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1813009272287526912

Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area

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