Genetic polymorphisms of infectious diseases in case-control studies

Detalhes bibliográficos
Autor(a) principal: Pacheco, Antonio G.
Data de Publicação: 2009
Outros Autores: Moraes, Milton O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29050
Resumo: Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil.
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spelling Pacheco, Antonio G.Moraes, Milton O.2018-09-25T17:13:09Z2018-09-25T17:13:09Z2009PACHECO, Antonio G.; MORAES, Milton O. Genetic polymorphisms of infectious diseases in case-control studies. Disease Markers, v.27, p.173-186, 2009.0278-0240https://www.arca.fiocruz.br/handle/icict/2905010.3233/DMA-2009-06541875-8630engHindawi Publishing CorporationTuberculoseHanseníaseCitocinasPopulaçãoInterleucina-10Fator Necrose TumoralPopulationSNPsCytokinestuberculosisleprosyTNFIL-10Genetic polymorphisms of infectious diseases in case-control studiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.In the past decade, genetic epidemiological analyses in infectious diseases have increased drastically since the publication of human genome and all the subsequent projects analyzing human diversity at molecular level. The great majority of studies use classical epidemiological designs applied to genetic data, and more than 80% of published studies use population-based case-control designs with widely spread genetic markers in human genome, like short tandem repeats (STR) or single nucleotide polymorphisms (SNP), in genes chosen by their physiological association with the disease (candidate genes). Even though genetic data is less prone to several bias issues inherent to case-control studies, some care has to be taken when designing, performing, analyzing and interpreting results from such studies. Here we discuss some basic concepts of genetics and epidemiology as a departure to evaluate and review every step that should be followed to design, conduct, analyze, interpret and present data from those studies, using particularities of infectious diseases, especially leprosy and tuberculosis as models.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29050/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmilton_moraes_etal_IOC_2009.pdfmilton_moraes_etal_IOC_2009.pdfapplication/pdf493377https://www.arca.fiocruz.br/bitstream/icict/29050/2/milton_moraes_etal_IOC_2009.pdfac21cbec2b6aae98162155a9f062b292MD52TEXTmilton_moraes_etal_IOC_2009.pdf.txtmilton_moraes_etal_IOC_2009.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Genetic polymorphisms of infectious diseases in case-control studies
title Genetic polymorphisms of infectious diseases in case-control studies
spellingShingle Genetic polymorphisms of infectious diseases in case-control studies
Pacheco, Antonio G.
Tuberculose
Hanseníase
Citocinas
População
Interleucina-10
Fator Necrose Tumoral
Population
SNPs
Cytokines
tuberculosis
leprosy
TNF
IL-10
title_short Genetic polymorphisms of infectious diseases in case-control studies
title_full Genetic polymorphisms of infectious diseases in case-control studies
title_fullStr Genetic polymorphisms of infectious diseases in case-control studies
title_full_unstemmed Genetic polymorphisms of infectious diseases in case-control studies
title_sort Genetic polymorphisms of infectious diseases in case-control studies
author Pacheco, Antonio G.
author_facet Pacheco, Antonio G.
Moraes, Milton O.
author_role author
author2 Moraes, Milton O.
author2_role author
dc.contributor.author.fl_str_mv Pacheco, Antonio G.
Moraes, Milton O.
dc.subject.other.pt_BR.fl_str_mv Tuberculose
Hanseníase
Citocinas
População
Interleucina-10
Fator Necrose Tumoral
topic Tuberculose
Hanseníase
Citocinas
População
Interleucina-10
Fator Necrose Tumoral
Population
SNPs
Cytokines
tuberculosis
leprosy
TNF
IL-10
dc.subject.en.pt_BR.fl_str_mv Population
SNPs
Cytokines
tuberculosis
leprosy
TNF
IL-10
description Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2018-09-25T17:13:09Z
dc.date.available.fl_str_mv 2018-09-25T17:13:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PACHECO, Antonio G.; MORAES, Milton O. Genetic polymorphisms of infectious diseases in case-control studies. Disease Markers, v.27, p.173-186, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29050
dc.identifier.issn.pt_BR.fl_str_mv 0278-0240
dc.identifier.doi.none.fl_str_mv 10.3233/DMA-2009-0654
dc.identifier.eissn.none.fl_str_mv 1875-8630
identifier_str_mv PACHECO, Antonio G.; MORAES, Milton O. Genetic polymorphisms of infectious diseases in case-control studies. Disease Markers, v.27, p.173-186, 2009.
0278-0240
10.3233/DMA-2009-0654
1875-8630
url https://www.arca.fiocruz.br/handle/icict/29050
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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