Avaliação da atividade macrofagica na hanseníase virchowiana e tuberculóide

• Autor(a) principal: Foss, Norma Tiraboschi
• Data de Publicação: 1995
• Outros Autores: Oliveira, Meire Soares de Atafde, Silva, Célio Lopes
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Hansenologia Internationalis (Online)
• Texto Completo: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35445
• topic: macro fagos; hanseníase; fator de necrose tumoral aTNF; Macrophages; leprosy; tumor necrosis factor aTNF

To verify the immunologic alternations related to the polar forms of leprosy the aTNF (tumor necrosis factor), levels was determined in vivo" and in vitro" in 31 individuals: lepromatous leprosy - 1, tuberculoid leprosy - 10 and normal controls - 10. PBMC (peripheral blood mononuclear cells) were cultured during 24 hs/379C/CO2 atmosphere and aTNF levels were  easured by ELISA assay, at the cultures supernatants and the serum from the three groups of individuals. The results (pg/ml) showed TNF levels significantly higher in tuberculoids patients when compared with the levels of lepromatous leprosy (LL) or controls, indicating a deficit in development and maintenance of immunecellular response, favouring the infection dissemination in LLpatients. The negative correlation between aTNF levels and baciloscopic index suggest that elevated baciloscopic levels are associated with immunecelular supression.