Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure

Detalhes bibliográficos
Autor(a) principal: Serra, Salvador Manoel
Data de Publicação: 2009
Outros Autores: Costa, Ricardo Vivacqua, Castro, Renata RodriguesTeixeira De, Xavier, Sergio Salles, Nobrega, Antonio Claudio Lucas da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.cardfail.2008.10.018
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38877
Resumo: Sérgio Salles Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Serra, Salvador ManoelCosta, Ricardo VivacquaCastro, Renata RodriguesTeixeira DeXavier, Sergio SallesNobrega, Antonio Claudio Lucas da2019-12-27T11:58:54Z2019-12-27T11:58:54Z2009SERRA, Salvador Manoel et al. Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure. Journal of Cardiac Failure, v. 15, n. 2, p. 124-129, 2009.1071-9164https://www.arca.fiocruz.br/handle/icict/3887710.1016/j.cardfail.2008.10.0181532-8414Sérgio Salles Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-12-27Fluminense Federal University. Department of Physiology and Pharmacology. Niterói, RJ, Brazil / Fluminense Federal University. Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil / Rio de Janeiro Federal University. Division of Cardiology. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Department of Physiology and Pharmacology. Niterói, RJ, Brazil / Fluminense Federal University. Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil.Fluminense Federal University. Department of Physiology and Pharmacology. Niterói, RJ, Brazil / Fluminense Federal University. Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil.Rio de Janeiro Federal University. Division of Cardiology. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Department of Physiology and Pharmacology. Niterói, RJ, Brazil / Fluminense Federal University. Post-Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil.Background: Parasympathetic dysfunction is an independent risk factor for mortality in heart failure for which there is no specific pharmacologic treatment. This article aims to determine the effect of pyridostigmine, an anticholinesterase agent, on the integrated physiologic responses to dynamic exercise in heart failure. Methods and Results: Patients with chronic heart failure (n = 23; 9 female; age= 48 +/-12 years) were submitted to 3 maximal cardiopulmonary exercise tests on treadmill in different days. The first test was used for adaptation and to determine exercise tolerance. The other tests were performed after oral administration of pyridostigmine (45 mg, 3 times/day, for 24 hours) or placebo, in random order. All patients were taking their usual medication. Pyridostigmine reduced cholinesterase activity by 30%, inhibitedthe chronotropic response throughout exercise, up to 60% of maximal effort (pyridostigmine510863 beats/min vs. placebo = 113 +/- 3 beats/min; P = .040), and improved heart rate reserve (pyridostigmine = 73 +/- 5 beats/min vs. placebo = 69 +/- 5 beats/min; P = 0.035) and heart rate recovery in the first minute after exercise (pyridostigmine = 25 +/- 2 beats/min vs. placebo = 22 +/- 2 beats/min; P = .005), whereas peak heart rate was similar to placebo. Oxygen pulse, an indirect indicator of stroke volume, was higher under pyridostigmine during submaximal exercise. Conclusions: Pyridostigmine was well tolerated by heart failure patients, leading to improved hemoynamic profile during dynamic exercise.engElsevierCholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAutonomic nervous systemVagalAcetylcholinesteraseOxygen pulseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/38877/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Serra_Salvador_etal_INI_2009.pdfve_Serra_Salvador_etal_INI_2009.pdfapplication/pdf215466https://www.arca.fiocruz.br/bitstream/icict/38877/2/ve_Serra_Salvador_etal_INI_2009.pdfb1da9e739088d323676db762f8e3893eMD52TEXTve_Serra_Salvador_etal_INI_2009.pdf.txtve_Serra_Salvador_etal_INI_2009.pdf.txtExtracted texttext/plain34756https://www.arca.fiocruz.br/bitstream/icict/38877/3/ve_Serra_Salvador_etal_INI_2009.pdf.txtbcff266d386ad96d9d9ee1f2b4bbdd89MD53icict/388772021-03-24 16:32:41.039oai:www.arca.fiocruz.br:icict/38877Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:41Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure
title Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure
spellingShingle Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure
Serra, Salvador Manoel
Autonomic nervous system
Vagal
Acetylcholinesterase
Oxygen pulse
title_short Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure
title_full Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure
title_fullStr Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure
title_full_unstemmed Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure
title_sort Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure
author Serra, Salvador Manoel
author_facet Serra, Salvador Manoel
Costa, Ricardo Vivacqua
Castro, Renata RodriguesTeixeira De
Xavier, Sergio Salles
Nobrega, Antonio Claudio Lucas da
author_role author
author2 Costa, Ricardo Vivacqua
Castro, Renata RodriguesTeixeira De
Xavier, Sergio Salles
Nobrega, Antonio Claudio Lucas da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Serra, Salvador Manoel
Costa, Ricardo Vivacqua
Castro, Renata RodriguesTeixeira De
Xavier, Sergio Salles
Nobrega, Antonio Claudio Lucas da
dc.subject.en.pt_BR.fl_str_mv Autonomic nervous system
Vagal
Acetylcholinesterase
Oxygen pulse
topic Autonomic nervous system
Vagal
Acetylcholinesterase
Oxygen pulse
description Sérgio Salles Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-12-27T11:58:54Z
dc.date.available.fl_str_mv 2019-12-27T11:58:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SERRA, Salvador Manoel et al. Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure. Journal of Cardiac Failure, v. 15, n. 2, p. 124-129, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38877
dc.identifier.issn.pt_BR.fl_str_mv 1071-9164
dc.identifier.doi.none.fl_str_mv 10.1016/j.cardfail.2008.10.018
dc.identifier.eissn.none.fl_str_mv 1532-8414
identifier_str_mv SERRA, Salvador Manoel et al. Cholinergic stimulation improves autonomic and hemodynamic profile during dynamic exercise in patients with heart failure. Journal of Cardiac Failure, v. 15, n. 2, p. 124-129, 2009.
1071-9164
10.1016/j.cardfail.2008.10.018
1532-8414
url https://www.arca.fiocruz.br/handle/icict/38877
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
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