CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil

Detalhes bibliográficos
Autor(a) principal: Araújo, Fernanda Fortes de
Data de Publicação: 2020
Outros Autores: Torres, Karen Cecília Lima, Peixoto, Sérgio William Viana, Ribeiro, Antonio Luiz Pinho, Mambrini, Juliana Vaz de Melo, Rezende, Vítor Bortolo de, Silva, Maria Luiza Lima, Filho, Antônio Ignácio Loyola, Carvalho, Andréa Teixeira de, Costa, Maria Fernanda Furtado Lima, Martins Filho, Olindo Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1186/s40249-020-00663-w
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41533
Resumo: Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil.
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spelling Araújo, Fernanda Fortes deTorres, Karen Cecília LimaPeixoto, Sérgio William VianaRibeiro, Antonio Luiz PinhoMambrini, Juliana Vaz de MeloRezende, Vítor Bortolo deSilva, Maria Luiza LimaFilho, Antônio Ignácio LoyolaCarvalho, Andréa Teixeira deCosta, Maria Fernanda Furtado LimaMartins Filho, Olindo Assis2020-06-04T17:55:49Z2020-06-04T17:55:49Z2020ARAÚJO, Fernanda Fortes de et al. CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil. Infectious Diseases of Poverty, v. 9, p. 1-10, 2020.2049-9957https://www.arca.fiocruz.br/handle/icict/4153310.1186/s40249-020-00663-wengBioMed CentralCXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil / Universidade José do Rosário Vellano. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais.Faculdade de Medicina. Hospital Clínico. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil.Background: Chagas disease is endemic in Latin America and still represents an important public health problem in the region. Chronic cardiomyopathy is the most significant chronic form due to its association with morbidity and mortality. The last decade has seen increasing evidence that inflammatory cytokines and chemokines are responsible for the generation of inflammatory infiltrate and tissue damage, with chronic chagasic cardiomyopathy patients presenting a pro-inflammatory immune response. Although studies have evaluated the role of chemokines in experimental T. cruzi infection, few have addressed their systemic profile, especially for human infection and in aging populations. The present work aimed to use the data from a large population based study of older adults, conducted in an endemic area for Chagas disease, to examine the association between serum levels of cytokines and chemokines, T. cruzi infection and electrocardiogram (ECG) abnormality. Methods: The present work evaluated serum levels of CCL2, CXCL9, CXCL10, CCL5, CXCL8, IL-1β, IL-6, TNF, IL-12 and IL-10 by Flow Cytometric Bead Array assay (CBA) and the results expressed in pg/ml. The baseline survey started in January 1st 1997, with 1284 participants of an aged population-based cohort. Participants signed an informed consent at baseline and at each subsequent visit and authorized death certificate and medical records verification. Results: Our results demonstrated that Chagas disease patients had higher serum levels of CXCL9, CXCL10 and IL-1β and lower serum levels of CCL5 than non-infected subjects. Moreover, our data demonstrated that CXCL9 and CXCL10 increased in an age-dependent profile in Chagas disease patients. Conclusion: Together, this study provided evidences that serum biomarkers increase along the age continuum and may have potential implications for establishing clinical management protocols and therapeutic intervention in Chagas disease patients.Chagas diseaseImmune biomarkersChemokinesCytokinesCohortinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/41533/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCXCL9 and CXCL10 display an age-dependent.pdfCXCL9 and CXCL10 display an age-dependent.pdfapplication/pdf945942https://www.arca.fiocruz.br/bitstream/icict/41533/2/CXCL9%20and%20CXCL10%20display%20an%20age-dependent.pdf205ba657bb11ee38f0a625066d601f60MD52TEXTCXCL9 and CXCL10 display an age-dependent.pdf.txtCXCL9 and CXCL10 display an age-dependent.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil
title CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil
spellingShingle CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil
Araújo, Fernanda Fortes de
Chagas disease
Immune biomarkers
Chemokines
Cytokines
Cohort
title_short CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil
title_full CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil
title_fullStr CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil
title_full_unstemmed CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil
title_sort CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil
author Araújo, Fernanda Fortes de
author_facet Araújo, Fernanda Fortes de
Torres, Karen Cecília Lima
Peixoto, Sérgio William Viana
Ribeiro, Antonio Luiz Pinho
Mambrini, Juliana Vaz de Melo
Rezende, Vítor Bortolo de
Silva, Maria Luiza Lima
Filho, Antônio Ignácio Loyola
Carvalho, Andréa Teixeira de
Costa, Maria Fernanda Furtado Lima
Martins Filho, Olindo Assis
author_role author
author2 Torres, Karen Cecília Lima
Peixoto, Sérgio William Viana
Ribeiro, Antonio Luiz Pinho
Mambrini, Juliana Vaz de Melo
Rezende, Vítor Bortolo de
Silva, Maria Luiza Lima
Filho, Antônio Ignácio Loyola
Carvalho, Andréa Teixeira de
Costa, Maria Fernanda Furtado Lima
Martins Filho, Olindo Assis
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Fernanda Fortes de
Torres, Karen Cecília Lima
Peixoto, Sérgio William Viana
Ribeiro, Antonio Luiz Pinho
Mambrini, Juliana Vaz de Melo
Rezende, Vítor Bortolo de
Silva, Maria Luiza Lima
Filho, Antônio Ignácio Loyola
Carvalho, Andréa Teixeira de
Costa, Maria Fernanda Furtado Lima
Martins Filho, Olindo Assis
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Immune biomarkers
Chemokines
Cytokines
Cohort
topic Chagas disease
Immune biomarkers
Chemokines
Cytokines
Cohort
description Fundação Oswaldo Cruz. Instituto Rene Rachou. Grupo Integrado de Pesquisa em Biomarcadores. Belo Horizonte, MG, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-06-04T17:55:49Z
dc.date.available.fl_str_mv 2020-06-04T17:55:49Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAÚJO, Fernanda Fortes de et al. CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil. Infectious Diseases of Poverty, v. 9, p. 1-10, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41533
dc.identifier.issn.pt_BR.fl_str_mv 2049-9957
dc.identifier.doi.none.fl_str_mv 10.1186/s40249-020-00663-w
identifier_str_mv ARAÚJO, Fernanda Fortes de et al. CXCL9 and CXCL10 display an age-dependent profile in chagas patients: a cohort study of aging in bambui, Brazil. Infectious Diseases of Poverty, v. 9, p. 1-10, 2020.
2049-9957
10.1186/s40249-020-00663-w
url https://www.arca.fiocruz.br/handle/icict/41533
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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