Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection

Detalhes bibliográficos
Autor(a) principal: Nascimento, Leile Camila Jacob
Data de Publicação: 2021
Outros Autores: Carvalho, Caroline Xavier, Silva, Monaıse Madalena Oliveira, Kikuti, Mariana Araújo, Anjos, Rosângela Oliveira, Fradico, Jordana Rodrigues Barbosa, Azevedo, Ana Carolina Campi, Tauro, Laura Beatriz, Campos, Gúbio Soares, Moreira, Patricia Sousa dos Santos, Portilho, Moyra Machado, Martins Filho, Olindo Assis, Ribeiro, Guilherme de Sousa, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49823
Resumo: 1 Instituto Gonc¸alo Moniz, Fundac¸ão Oswaldo Cruz, Salvador, Brazil, 2 Instituto Oswaldo Cruz, Fundac¸ão Oswaldo Cruz, Rio de Janeiro, Brazil, 3 Instituto de Sau´ de Coletiva, Universidade Federal da Bahia, Salvador, Brazil, 4 Instituto Rene´ Rachou, Fundac¸ão Oswaldo Cruz, Belo Horizonte, Brazil, 5 Instituto de Biologia Subtropical, Consejo Nacional de Investigaciones Científicas y Tecnicas - Universidad Nacional de Misiones, Puerto Iguazu´ , Argentina, 6 Instituto de Cieˆ ncias da Sau´ de, Universidade Federal da Bahia, Salvador, Brazil, 7 Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil, 8 Yale School of Public Health, Yale University, New Haven, CT, United States
id CRUZ_b7b350d2e31a5ee778962bbc8194e271
oai_identifier_str oai:www.arca.fiocruz.br:icict/49823
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Nascimento, Leile Camila JacobCarvalho, Caroline XavierSilva, Monaıse Madalena OliveiraKikuti, Mariana AraújoAnjos, Rosângela OliveiraFradico, Jordana Rodrigues BarbosaAzevedo, Ana Carolina CampiTauro, Laura BeatrizCampos, Gúbio SoaresMoreira, Patricia Sousa dos SantosPortilho, Moyra MachadoMartins Filho, Olindo AssisRibeiro, Guilherme de SousaReis, Mitermayer Galvão dos2021-11-12T18:35:59Z2021-11-12T18:35:59Z2021NASCIMENTO, Leile Camila Jacob et al. Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection. Frontiers in Immunology, 2021.1664-3224https://www.arca.fiocruz.br/handle/icict/4982310.3389/fimmu.2021.7441831 Instituto Gonc¸alo Moniz, Fundac¸ão Oswaldo Cruz, Salvador, Brazil, 2 Instituto Oswaldo Cruz, Fundac¸ão Oswaldo Cruz, Rio de Janeiro, Brazil, 3 Instituto de Sau´ de Coletiva, Universidade Federal da Bahia, Salvador, Brazil, 4 Instituto Rene´ Rachou, Fundac¸ão Oswaldo Cruz, Belo Horizonte, Brazil, 5 Instituto de Biologia Subtropical, Consejo Nacional de Investigaciones Científicas y Tecnicas - Universidad Nacional de Misiones, Puerto Iguazu´ , Argentina, 6 Instituto de Cieˆ ncias da Sau´ de, Universidade Federal da Bahia, Salvador, Brazil, 7 Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil, 8 Yale School of Public Health, Yale University, New Haven, CT, United StatesBrazilian National Council for Scientific and Technological Development under Grants 400830/ 2013-2 and 440891/2016-7 to GR, and scholarships to LT, MR, and GR; the Bahia Foundation for Research Support under Grants PET0026/2013, PP0044/2016, and PET0022/2016 to GR, and scholarship to MS; the Coordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education under grant 88881.130749/2016-01 to GR; the Department of Science and Technology, Secretariat of Science, Technology and Strategic Inputs, Brazilian Ministry of Health; the Federal University of Bahia; the Oswaldo Cruz Foundation; and the REPLICK (Clinical and Applied Research in Chikungunya). OM-F is a research fellow from FAPEAM (PVN-II, PRÓ -ESTADO Program #005/2019)."Múltipla ver em Notas"The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acutephase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months vs >3 months), presence of anti-CHIKV IgM at acute-phase sample, and number of days of symptoms at sample collection (1 vs 2-3 vs ≥4). Patients with acute CHIKV infection had significantly higher levels of CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-1b, IL-6, IL-12, and IL-10 as compared to HC. CCL2, CCL5, and CXCL10 levels were also significantly higher in patients with CHIKV infection compared to patients with OAFD. Patients whose arthralgia lasted > 3 months had increased CXCL8 levels compared to patients whose arthralgia did not (p<0.05). Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting >3 months. Patients with chikungunya and OAFD had similar cytokine kinetics for IL-1b, IL-12, TNF, IFN-g, IL-2, and IL-4, although the levels were lower for CHIKV patients. This study suggests that chemokines may have an important role in the immunopathogenesis of chronic chikungunya-related arthralgia.engFrontiers MediaArtralgia crônicaQuimiocinasCitocinasChikungunyaBiomarcadoresCoorteChronic arthralgiaChemokinesCytokinesChikungunyaSerum biomarkersCohortAcute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49823/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALNascimento, Leile Camila Jacob Acute Phase....pdfNascimento, Leile Camila Jacob Acute Phase....pdfapplication/pdf1326508https://www.arca.fiocruz.br/bitstream/icict/49823/2/Nascimento%2c%20Leile%20Camila%20Jacob%20Acute%20Phase....pdfc607a98faf30d9b17931b3368761e630MD52icict/498232023-03-15 14:34:30.11oai:www.arca.fiocruz.br:icict/49823Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUw0KDQpBbmEgTWFyaWEgRmlzY2luYSBTYW1wYWlvLCBDUEY6IDA2NS40MzEuMDM1LTE1LCB2aW5jdWxhZG8gYSBDUHFHTSAtIENlbnRybyBkZSBQZXNxdWlzYXMgR29uw6dhbG8gTW9uaXoKCkFvIGFjZWl0YXIgb3MgVEVSTU9TIGUgQ09OREnDh8OVRVMgZGVzdGEgQ0VTU8ODTywgbyBBVVRPUiBlL291IFRJVFVMQVIgZGUgZGlyZWl0b3MKYXV0b3JhaXMgc29icmUgYSBPQlJBIGRlIHF1ZSB0cmF0YSBlc3RlIGRvY3VtZW50bzoKCigxKSBDRURFIGUgVFJBTlNGRVJFLCB0b3RhbCBlIGdyYXR1aXRhbWVudGUsIMOgIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiwgZW0KY2Fyw6F0ZXIgcGVybWFuZW50ZSwgaXJyZXZvZ8OhdmVsIGUgTsODTyBFWENMVVNJVk8sIHRvZG9zIG9zIGRpcmVpdG9zIHBhdHJpbW9uaWFpcyBOw4NPCkNPTUVSQ0lBSVMgZGUgdXRpbGl6YcOnw6NvIGRhIE9CUkEgYXJ0w61zdGljYSBlL291IGNpZW50w61maWNhIGluZGljYWRhIGFjaW1hLCBpbmNsdXNpdmUgb3MgZGlyZWl0b3MKZGUgdm96IGUgaW1hZ2VtIHZpbmN1bGFkb3Mgw6AgT0JSQSwgZHVyYW50ZSB0b2RvIG8gcHJhem8gZGUgZHVyYcOnw6NvIGRvcyBkaXJlaXRvcyBhdXRvcmFpcywgZW0KcXVhbHF1ZXIgaWRpb21hIGUgZW0gdG9kb3Mgb3MgcGHDrXNlczsKCigyKSBBQ0VJVEEgcXVlIGEgY2Vzc8OjbyB0b3RhbCBuw6NvIGV4Y2x1c2l2YSwgcGVybWFuZW50ZSBlIGlycmV2b2fDoXZlbCBkb3MgZGlyZWl0b3MgYXV0b3JhaXMKcGF0cmltb25pYWlzIG7Do28gY29tZXJjaWFpcyBkZSB1dGlsaXphw6fDo28gZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvIGluY2x1aSwgZXhlbXBsaWZpY2F0aXZhbWVudGUsCm9zIGRpcmVpdG9zIGRlIGRpc3BvbmliaWxpemHDp8OjbyBlIGNvbXVuaWNhw6fDo28gcMO6YmxpY2EgZGEgT0JSQSwgZW0gcXVhbHF1ZXIgbWVpbyBvdSB2ZcOtY3VsbywKaW5jbHVzaXZlIGVtIFJlcG9zaXTDs3Jpb3MgRGlnaXRhaXMsIGJlbSBjb21vIG9zIGRpcmVpdG9zIGRlIHJlcHJvZHXDp8OjbywgZXhpYmnDp8OjbywgZXhlY3XDp8OjbywKZGVjbGFtYcOnw6NvLCByZWNpdGHDp8OjbywgZXhwb3Npw6fDo28sIGFycXVpdmFtZW50bywgaW5jbHVzw6NvIGVtIGJhbmNvIGRlIGRhZG9zLCBwcmVzZXJ2YcOnw6NvLCBkaWZ1c8OjbywKZGlzdHJpYnVpw6fDo28sIGRpdnVsZ2HDp8OjbywgZW1wcsOpc3RpbW8sIHRyYWR1w6fDo28sIGR1YmxhZ2VtLCBsZWdlbmRhZ2VtLCBpbmNsdXPDo28gZW0gbm92YXMgb2JyYXMgb3UKY29sZXTDom5lYXMsIHJldXRpbGl6YcOnw6NvLCBlZGnDp8OjbywgcHJvZHXDp8OjbyBkZSBtYXRlcmlhbCBkaWTDoXRpY28gZSBjdXJzb3Mgb3UgcXVhbHF1ZXIgZm9ybWEgZGUKdXRpbGl6YcOnw6NvIG7Do28gY29tZXJjaWFsOwoKKDMpIFJFQ09OSEVDRSBxdWUgYSBjZXNzw6NvIGFxdWkgZXNwZWNpZmljYWRhIGNvbmNlZGUgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETwpDUlVaIG8gZGlyZWl0byBkZSBhdXRvcml6YXIgcXVhbHF1ZXIgcGVzc29hIOKAkyBmw61zaWNhIG91IGp1csOtZGljYSwgcMO6YmxpY2Egb3UgcHJpdmFkYSwgbmFjaW9uYWwgb3UKZXN0cmFuZ2VpcmEg4oCTIGEgYWNlc3NhciBlIHV0aWxpemFyIGFtcGxhbWVudGUgYSBPQlJBLCBzZW0gZXhjbHVzaXZpZGFkZSwgcGFyYSBxdWFpc3F1ZXIKZmluYWxpZGFkZXMgbsOjbyBjb21lcmNpYWlzOwoKKDQpIERFQ0xBUkEgcXVlIGEgb2JyYSDDqSBjcmlhw6fDo28gb3JpZ2luYWwgZSBxdWUgw6kgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBhcXVpIGNlZGlkb3MgZSBhdXRvcml6YWRvcywKcmVzcG9uc2FiaWxpemFuZG8tc2UgaW50ZWdyYWxtZW50ZSBwZWxvIGNvbnRlw7pkbyBlIG91dHJvcyBlbGVtZW50b3MgcXVlIGZhemVtIHBhcnRlIGRhIE9CUkEsCmluY2x1c2l2ZSBvcyBkaXJlaXRvcyBkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBvYnJpZ2FuZG8tc2UgYSBpbmRlbml6YXIgdGVyY2Vpcm9zIHBvcgpkYW5vcywgYmVtIGNvbW8gaW5kZW5pemFyIGUgcmVzc2FyY2lyIGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIGRlCmV2ZW50dWFpcyBkZXNwZXNhcyBxdWUgdmllcmVtIGEgc3Vwb3J0YXIsIGVtIHJhesOjbyBkZSBxdWFscXVlciBvZmVuc2EgYSBkaXJlaXRvcyBhdXRvcmFpcyBvdQpkaXJlaXRvcyBkZSB2b3ogb3UgaW1hZ2VtLCBwcmluY2lwYWxtZW50ZSBubyBxdWUgZGl6IHJlc3BlaXRvIGEgcGzDoWdpbyBlIHZpb2xhw6fDtWVzIGRlIGRpcmVpdG9zOwoKKDUpIEFGSVJNQSBxdWUgY29uaGVjZSBhIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08KT1NXQUxETyBDUlVaIGUgYXMgZGlyZXRyaXplcyBwYXJhIG8gZnVuY2lvbmFtZW50byBkbyByZXBvc2l0w7NyaW8gaW5zdGl0dWNpb25hbCBBUkNBLgoKQSBQb2zDrXRpY2EgSW5zdGl0dWNpb25hbCBkZSBBY2Vzc28gQWJlcnRvIGRhIEZJT0NSVVogLSBGVU5EQcOHw4NPIE9TV0FMRE8gQ1JVWiByZXNlcnZhCmV4Y2x1c2l2YW1lbnRlIGFvIEFVVE9SIG9zIGRpcmVpdG9zIG1vcmFpcyBlIG9zIHVzb3MgY29tZXJjaWFpcyBzb2JyZSBhcyBvYnJhcyBkZSBzdWEgYXV0b3JpYQplL291IHRpdHVsYXJpZGFkZSwgc2VuZG8gb3MgdGVyY2Vpcm9zIHVzdcOhcmlvcyByZXNwb25zw6F2ZWlzIHBlbGEgYXRyaWJ1acOnw6NvIGRlIGF1dG9yaWEgZSBtYW51dGVuw6fDo28KZGEgaW50ZWdyaWRhZGUgZGEgT0JSQSBlbSBxdWFscXVlciB1dGlsaXphw6fDo28uCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaCnJlc3BlaXRhIG9zIGNvbnRyYXRvcyBlIGFjb3Jkb3MgcHJlZXhpc3RlbnRlcyBkb3MgQXV0b3JlcyBjb20gdGVyY2Vpcm9zLCBjYWJlbmRvIGFvcyBBdXRvcmVzCmluZm9ybWFyIMOgIEluc3RpdHVpw6fDo28gYXMgY29uZGnDp8O1ZXMgZSBvdXRyYXMgcmVzdHJpw6fDtWVzIGltcG9zdGFzIHBvciBlc3RlcyBpbnN0cnVtZW50b3MuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
title Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
spellingShingle Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
Nascimento, Leile Camila Jacob
Artralgia crônica
Quimiocinas
Citocinas
Chikungunya
Biomarcadores
Coorte
Chronic arthralgia
Chemokines
Cytokines
Chikungunya
Serum biomarkers
Cohort
title_short Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
title_full Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
title_fullStr Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
title_full_unstemmed Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
title_sort Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
author Nascimento, Leile Camila Jacob
author_facet Nascimento, Leile Camila Jacob
Carvalho, Caroline Xavier
Silva, Monaıse Madalena Oliveira
Kikuti, Mariana Araújo
Anjos, Rosângela Oliveira
Fradico, Jordana Rodrigues Barbosa
Azevedo, Ana Carolina Campi
Tauro, Laura Beatriz
Campos, Gúbio Soares
Moreira, Patricia Sousa dos Santos
Portilho, Moyra Machado
Martins Filho, Olindo Assis
Ribeiro, Guilherme de Sousa
Reis, Mitermayer Galvão dos
author_role author
author2 Carvalho, Caroline Xavier
Silva, Monaıse Madalena Oliveira
Kikuti, Mariana Araújo
Anjos, Rosângela Oliveira
Fradico, Jordana Rodrigues Barbosa
Azevedo, Ana Carolina Campi
Tauro, Laura Beatriz
Campos, Gúbio Soares
Moreira, Patricia Sousa dos Santos
Portilho, Moyra Machado
Martins Filho, Olindo Assis
Ribeiro, Guilherme de Sousa
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, Leile Camila Jacob
Carvalho, Caroline Xavier
Silva, Monaıse Madalena Oliveira
Kikuti, Mariana Araújo
Anjos, Rosângela Oliveira
Fradico, Jordana Rodrigues Barbosa
Azevedo, Ana Carolina Campi
Tauro, Laura Beatriz
Campos, Gúbio Soares
Moreira, Patricia Sousa dos Santos
Portilho, Moyra Machado
Martins Filho, Olindo Assis
Ribeiro, Guilherme de Sousa
Reis, Mitermayer Galvão dos
dc.subject.other.pt_BR.fl_str_mv Artralgia crônica
Quimiocinas
Citocinas
Chikungunya
Biomarcadores
Coorte
topic Artralgia crônica
Quimiocinas
Citocinas
Chikungunya
Biomarcadores
Coorte
Chronic arthralgia
Chemokines
Cytokines
Chikungunya
Serum biomarkers
Cohort
dc.subject.en.pt_BR.fl_str_mv Chronic arthralgia
Chemokines
Cytokines
Chikungunya
Serum biomarkers
Cohort
description 1 Instituto Gonc¸alo Moniz, Fundac¸ão Oswaldo Cruz, Salvador, Brazil, 2 Instituto Oswaldo Cruz, Fundac¸ão Oswaldo Cruz, Rio de Janeiro, Brazil, 3 Instituto de Sau´ de Coletiva, Universidade Federal da Bahia, Salvador, Brazil, 4 Instituto Rene´ Rachou, Fundac¸ão Oswaldo Cruz, Belo Horizonte, Brazil, 5 Instituto de Biologia Subtropical, Consejo Nacional de Investigaciones Científicas y Tecnicas - Universidad Nacional de Misiones, Puerto Iguazu´ , Argentina, 6 Instituto de Cieˆ ncias da Sau´ de, Universidade Federal da Bahia, Salvador, Brazil, 7 Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil, 8 Yale School of Public Health, Yale University, New Haven, CT, United States
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-12T18:35:59Z
dc.date.available.fl_str_mv 2021-11-12T18:35:59Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NASCIMENTO, Leile Camila Jacob et al. Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection. Frontiers in Immunology, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49823
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2021.744183
identifier_str_mv NASCIMENTO, Leile Camila Jacob et al. Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection. Frontiers in Immunology, 2021.
1664-3224
10.3389/fimmu.2021.744183
url https://www.arca.fiocruz.br/handle/icict/49823
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49823/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49823/2/Nascimento%2c%20Leile%20Camila%20Jacob%20Acute%20Phase....pdf
bitstream.checksum.fl_str_mv 36b51ef91c52b5338d9d29ba0cc807bc
c607a98faf30d9b17931b3368761e630
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009290017898496