What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?

Detalhes bibliográficos
Autor(a) principal: Goodreau, Steven M.
Data de Publicação: 2012
Outros Autores: Carnegie, Nicole B., Vittinghoff, Eric, Lama, Javier R., Sanchez, Jorge, Grinsztejn, Beatriz, Koblin, Beryl A., Mayer, Kenneth H., Buchbinder, Susan P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29954
Resumo: University of Washington. Department of Anthropology. Seattle, Washington, United States of America.
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spelling Goodreau, Steven M.Carnegie, Nicole B.Vittinghoff, EricLama, Javier R.Sanchez, JorgeGrinsztejn, BeatrizKoblin, Beryl A.Mayer, Kenneth H.Buchbinder, Susan P.2018-11-08T14:20:06Z2018-11-08T14:20:06Z2012GOODREAU, S. M. et al. What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)? PLoS ONE, v. 7, n. 11, p. e50522, 2012.1932-6203https://www.arca.fiocruz.br/handle/icict/2995410.1371/journal.pone.0050522engPatrick S. Sullivan, Rollins School of Public Health, Emory University, United States of AmericaWhat Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Washington. Department of Anthropology. Seattle, Washington, United States of America.Harvard School of Public Health. Department of Biostatistics. Boston, Massachusetts, United States of America.University of California San Francisco. Department of Epidemiology and Biostatistics. San Francisco, California, United States of America.Asociación Civil Impacta Salud y Educación. Lima, Peru.Asociación Civil Impacta Salud y Educación. Lima, Peru.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.New York Blood Center. Laboratory of Infectious Disease Prevention. New York City, NY, United States of America.Fenway Health. The Fenway Institute. Boston, Massachusetts, United States of America.San Francisco Department of Public Health. Bridge HIV. San Francisco, California, United States of America.In this work, we estimate the proportions of transmissions occurring in main vs. casual partnerships, and by the sexual role, infection stage, and testing and treatment history of the infected partner, for men who have sex with men (MSM) in the US and Peru. We use dynamic, stochastic models based in exponential random graph models (ERGMs), obtaining inputs from multiple large-scale MSM surveys. Parallel main partnership and casual sexual networks are simulated. Each man is characterized by age, race, circumcision status, sexual role behavior, and propensity for unprotected anal intercourse (UAI); his history is modeled from entry into the adult population, with potential transitions including HIV infection, detection, treatment, AIDS diagnosis, and death. We implemented two model variants differing in assumptions about acute infectiousness, and assessed sensitivity to other key inputs. Our two models suggested that only 4-5% (Model 1) or 22-29% (Model 2) of HIV transmission results from contacts with acute-stage partners; the plurality (80-81% and 49%, respectively) stem from chronic-stage partners and the remainder (14-16% and 27-35%, respectively) from AIDS-stage partners. Similar proportions of infections stem from partners whose infection is undiagnosed (24-31%), diagnosed but untreated (36-46%), and currently being treated (30-36%). Roughly one-third of infections (32-39%) occur within main partnerships. Results by country were qualitatively similar, despite key behavioral differences; one exception was that transmission from the receptive to insertive partner appears more important in Peru (34%) than the US (21%). The broad balance in transmission contexts suggests that education about risk, careful assessment, pre-exposure prophylaxis, more frequent testing, earlier treatment, and risk-reduction, disclosure, and adherence counseling may all contribute substantially to reducing the HIV incidence among MSM in the US and Peru.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/29954/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALWhat Drives the US and Peruvian_Beatriz_Grinsztejn_INI_LapClin-AIDS_2012.pdfWhat Drives the US and Peruvian_Beatriz_Grinsztejn_INI_LapClin-AIDS_2012.pdfapplication/pdf567570https://www.arca.fiocruz.br/bitstream/icict/29954/2/What%20Drives%20the%20US%20and%20Peruvian_Beatriz_Grinsztejn_INI_LapClin-AIDS_2012.pdf9dee51bde0430b788ff6f47e45b57cf1MD52TEXTWhat Drives the US and 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dc.title.pt_BR.fl_str_mv What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?
title What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?
spellingShingle What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?
Goodreau, Steven M.
title_short What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?
title_full What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?
title_fullStr What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?
title_full_unstemmed What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?
title_sort What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?
author Goodreau, Steven M.
author_facet Goodreau, Steven M.
Carnegie, Nicole B.
Vittinghoff, Eric
Lama, Javier R.
Sanchez, Jorge
Grinsztejn, Beatriz
Koblin, Beryl A.
Mayer, Kenneth H.
Buchbinder, Susan P.
author_role author
author2 Carnegie, Nicole B.
Vittinghoff, Eric
Lama, Javier R.
Sanchez, Jorge
Grinsztejn, Beatriz
Koblin, Beryl A.
Mayer, Kenneth H.
Buchbinder, Susan P.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Goodreau, Steven M.
Carnegie, Nicole B.
Vittinghoff, Eric
Lama, Javier R.
Sanchez, Jorge
Grinsztejn, Beatriz
Koblin, Beryl A.
Mayer, Kenneth H.
Buchbinder, Susan P.
description University of Washington. Department of Anthropology. Seattle, Washington, United States of America.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2018-11-08T14:20:06Z
dc.date.available.fl_str_mv 2018-11-08T14:20:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOODREAU, S. M. et al. What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)? PLoS ONE, v. 7, n. 11, p. e50522, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29954
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0050522
identifier_str_mv GOODREAU, S. M. et al. What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)? PLoS ONE, v. 7, n. 11, p. e50522, 2012.
1932-6203
10.1371/journal.pone.0050522
url https://www.arca.fiocruz.br/handle/icict/29954
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Patrick S. Sullivan, Rollins School of Public Health, Emory University, United States of America
publisher.none.fl_str_mv Patrick S. Sullivan, Rollins School of Public Health, Emory University, United States of America
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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