Immunopathology of cardiomyopathy in the experimental Chagas disease

Detalhes bibliográficos
Autor(a) principal: Soares, Milena Botelho Pereira
Data de Publicação: 1999
Outros Autores: Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5635
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Soares, Milena Botelho PereiraSantos, Ricardo Ribeiro dos2012-10-03T19:26:48Z2012-10-03T19:26:48Z1999SOARES, Milena Botelho Pereira; SANTOS, Ricardo Ribeiro do. Immunopathology of cardiomyopathy in the experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, Suppl 1, p. 257-262, 1999.0074-0276https://www.arca.fiocruz.br/handle/icict/5635engImmunopathology of cardiomyopathy in the experimental Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment. During the acute phase, the neuronal and cardiac fiber destruction occurs when ruptured parasite nests release T. cruzi antigens that bind to the cell surface in the vicinity which become targets for the cellular and humoral immune response against T. cruzi. The various factors involved in the genesis of autoimmunity in chronic T. cruzi infection include molecular mimicry, presentation of self-antigens and imbalance of immune regulation.CardiomyopathyImmunopathologyChagas diseaseTrypanosoma cruziAuto-Imunidade/imunologiaCardiomiopatia Chagásica/imunologiaTrypanosoma cruzi/imunologiaAnimaisLinfócitos T CD4-Positivos/imunologiaLinfócitos T CD8-Positivos/imunologiaLinhagem CelularCardiomiopatia Chagásica/patologiaCamundongosCamundongos Endogâmicos BALB CCamundongos NusMiocárdio/imunologiaMiocárdio/patologiaNeurônios/imunologiaNeurônios/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares MB Immunopathology of cardiomyopathy....pdfSoares MB Immunopathology of cardiomyopathy....pdfapplication/pdf367728https://www.arca.fiocruz.br/bitstream/icict/5635/1/Soares%20MB%20Immunopathology%20of%20cardiomyopathy....pdf6b0a866fd4f017001a6d2ae09af56b98MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5635/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTSoares MB Immunopathology of cardiomyopathy....pdf.txtSoares MB Immunopathology of cardiomyopathy....pdf.txtExtracted texttext/plain23161https://www.arca.fiocruz.br/bitstream/icict/5635/5/Soares%20MB%20Immunopathology%20of%20cardiomyopathy....pdf.txt6e897cd43bac0692c12e7781bd429956MD55THUMBNAILSoares MB Immunopathology of cardiomyopathy....pdf.jpgSoares MB Immunopathology of cardiomyopathy....pdf.jpgGenerated Thumbnailimage/jpeg2334https://www.arca.fiocruz.br/bitstream/icict/5635/4/Soares%20MB%20Immunopathology%20of%20cardiomyopathy....pdf.jpg119ae3918d17ce0308c6c83829da6bcaMD54icict/56352023-03-15 14:32:57.608oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Immunopathology of cardiomyopathy in the experimental Chagas disease
title Immunopathology of cardiomyopathy in the experimental Chagas disease
spellingShingle Immunopathology of cardiomyopathy in the experimental Chagas disease
Soares, Milena Botelho Pereira
Cardiomyopathy
Immunopathology
Chagas disease
Trypanosoma cruzi
Auto-Imunidade/imunologia
Cardiomiopatia Chagásica/imunologia
Trypanosoma cruzi/imunologia
Animais
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Linhagem Celular
Cardiomiopatia Chagásica/patologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Miocárdio/imunologia
Miocárdio/patologia
Neurônios/imunologia
Neurônios/patologia
title_short Immunopathology of cardiomyopathy in the experimental Chagas disease
title_full Immunopathology of cardiomyopathy in the experimental Chagas disease
title_fullStr Immunopathology of cardiomyopathy in the experimental Chagas disease
title_full_unstemmed Immunopathology of cardiomyopathy in the experimental Chagas disease
title_sort Immunopathology of cardiomyopathy in the experimental Chagas disease
author Soares, Milena Botelho Pereira
author_facet Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
author_role author
author2 Santos, Ricardo Ribeiro dos
author2_role author
dc.contributor.author.fl_str_mv Soares, Milena Botelho Pereira
Santos, Ricardo Ribeiro dos
dc.subject.en.pt_BR.fl_str_mv Cardiomyopathy
Immunopathology
Chagas disease
Trypanosoma cruzi
topic Cardiomyopathy
Immunopathology
Chagas disease
Trypanosoma cruzi
Auto-Imunidade/imunologia
Cardiomiopatia Chagásica/imunologia
Trypanosoma cruzi/imunologia
Animais
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Linhagem Celular
Cardiomiopatia Chagásica/patologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Miocárdio/imunologia
Miocárdio/patologia
Neurônios/imunologia
Neurônios/patologia
dc.subject.decs.pt_BR.fl_str_mv Auto-Imunidade/imunologia
Cardiomiopatia Chagásica/imunologia
Trypanosoma cruzi/imunologia
Animais
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Linhagem Celular
Cardiomiopatia Chagásica/patologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Miocárdio/imunologia
Miocárdio/patologia
Neurônios/imunologia
Neurônios/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2012-10-03T19:26:48Z
dc.date.available.fl_str_mv 2012-10-03T19:26:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, Milena Botelho Pereira; SANTOS, Ricardo Ribeiro do. Immunopathology of cardiomyopathy in the experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, Suppl 1, p. 257-262, 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5635
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv SOARES, Milena Botelho Pereira; SANTOS, Ricardo Ribeiro do. Immunopathology of cardiomyopathy in the experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, Suppl 1, p. 257-262, 1999.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5635
dc.language.iso.fl_str_mv eng
language eng
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